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Mr Simon Eastham

BSc, MRes

 https://orcid.org/0009-0005-3316-310X

  • BS8 1TD

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Collaborations and top research areas from the last five years

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  • 3 Article (Academic Journal)
  • 1 Chapter in a book

  • Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

    Jenkins, B. J., Jenkins, Y. R., Ponce-Garcia, F. M., Moscrop, C., Perry, I. A., Hitchings, M. D., Uribe, A. H., Bernuzzi, F., Eastham, S., Cronin, J. G., Berisha, A., Howell, A., Davies, J., Blagih, J., Williams, M., Marsden, M., Veale, D. J., Davies, L. C., Niphakis, M. & Finlay, D. K. & 14 others, Sinclair, L. V., Cravatt, B. F., Hogan, A. E., Nathan, J. A., Humphreys, I. R., Fearon, U., Sumpton, D., Vande Voorde, J., Vale, G. D. D., McDonald, J. G., Jones, G. W., Pearson, J. A., Vincent, E. E. & Jones, N., 3 Nov 2025, In: Nature Communications. 16, 1, 18 p., 9484.

    Research output: Contribution to journal › Article (Academic Journal) › peer-review

    Open Access

  • NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome

    Chen, R., Lukianova, E., Loeff, I. S. V. D., Spegarova, J. S., Willet, J. D. P., James, K. D., Ryder, E., IJspeert, H., Gajbhiye, A., Lamoliatte, F., Marín-Rubio, J. L., Woodbine, L., Lemos, H., Swan, D. J., Pintar, V., Sayes, K., Ruiz-Morales, E. R., Eastham, S., Dixon, D. & Prete, M. & 15 others, Prigmore, E., Jeggo, P., Boyes, J., Mellor, A., huang, L., Burg, M. V. D., Engelhardt, K. R., Stray-Pedersen, A., Erichsen, H. C., Gennery, A., Trost, M., anderson, G., Lorenc, A., Trynka, G. & Hambleton, S., 24 May 2024, In: Science Immunology. 9, 95, p. eade5705 eade5705.

    Research output: Contribution to journal › Article (Academic Journal) › peer-review

    4 Citations (Scopus)

  • Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

    Jenkins, B. J., Blagih, J., Ponce-Garcia, F. M., Canavan, M., Gudgeon, N., Eastham, S., Hill, D., Hanlon, M. M., Ma, E. H., Bishop, E. L., Rees, A., Cronin, J. G., Jury, E. C., Dimeloe, S. K., Veale, D. J., Thornton, C. A., Vousden, K. H., Finlay, D. K., Fearon, U. & Jones, G. W. & 3 others, Sinclair, L. V., Vincent, E. E. & Jones, N., 24 May 2023, (E-pub ahead of print) In: Cell Metabolism. 35, 7, p. 1132-1146.e9

    Research output: Contribution to journal › Article (Academic Journal) › peer-review

    Open Access
    76 Citations (Scopus)
View all 4 research outputs