Genetic risk factors involved in brain circuit changes caused by genetic vulnerability and early life adversity.
Childhood adversity is an established risk factor in the development of psychiatric disorders later in life. Not everyone who experiences such adversity goes on to develop them, however. It is thought that genetic vulnerabilities, together with brain circuit changes caused by adversity, are behind this discrepancy.
My work uses a rat model of genetic vulnerability in combination with a model of early life adversity to investigate the changes in brain circuitry behind psychiatric disorder development.