Projects per year
Personal profile
Research interests
Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.
We are studying the mechanisms through which the brain recognises environmental stress and disease, and the pathways it uses to initiate appropriate responses in physiological regulation and gene transcription. We have been particularly interested in the way the body utilises rhythmic activation of neuroendocrine response systems such as the hypothalamo-pituitary-adrenal axis to provide digital as well as analogue signals to glucocorticoid responsive tissues throughout the body.
In my clinical studies, we are developing novel ways of administrating glucocorticoid replacement to patients with adrenal insufficiency and have been developing systems to assess stress responses in disease and in patients undergoing surgery.
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Collaborations and top research areas from the last five years
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The PULSES Study: Pulsed glucocorticoid replacement therapy for patients with adrenocortical insufficiency secondary to Addison's Disease and Congenital Adrenal Hyperplasia
Lightman, S. L., Russell, G. M., Bradley, K. J., Kalafatakis, K., Durant, C. F., Simunkova, K., Johnson, A., Munafo, M. R., Harmer, C. J., Davey Smith, G., Timpson, N. J. & Sutton, E. J.
1/01/15 → …
Project: Research
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Research output
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High-resolution daily profiles of tissue adrenal steroids by portable automated collection
Upton, T. J., Zavala, E., Methlie, P., Kämpe, O., Tsagarakis, S., Øksnes, M., Bensing, S., Vassiliadi, D. A., Grytaas, M. A., Botusan, I. R., Ueland, G., Berinder, K., Simunkova, K., Balomenaki, M., Margaritopoulos, D., Henne, N., Crossley, R., Russell, G., Husebye, E. S. & Lightman, S. L., 21 Jun 2023, In: Science Translational Medicine. 15, 701, p. 1-16 eadg8464.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile35 Downloads (Pure) -
Transcriptional and cell type profiles of cortical brain regions showing ultradian cortisol rhythm dependent responses to emotional face stimulation
Habets, P. C., Kalafatakis, K., Dzyubachyk, O., van der Werff, S. J. A., Keo, A., Thakrar, J., Mahfouz, A., Pereira, A. M., Russell, G. M., Lightman, S. L. & Meijer, O. C., 22 Jan 2023, In: Neurobiology of Stress. 22, 100514.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile14 Downloads (Pure) -
Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats
Nishimura, H., Yoshimura, M., Shimizu, M., Sanada, K., Sonoda, S., Nishimura, K., Baba, K., Ikeda, N., Motojima, Y., Maruyama, T., Nonaka, Y., Baba, R., Onaka, T., Horishita, T., Morimoto, H., Yoshida, Y., Kawasaki, M., Sakai, A., Muratani, M., Conway-Campbell, B., & 2 others , 5 Sept 2022, In: Communications Biology. 5, 1, p. 907Research output: Contribution to journal › Article (Academic Journal) › peer-review
4 Citations (Scopus)
Datasets
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HABS 1.csv, Replication Data for: High resolution daily profiles of tissue adrenal steroids by portable automated collection
Upton, T. J. (Creator), Zavala, E. (Creator), Methlie, P. (Creator), Kämpe, O. (Creator), Tsagarakis, S. (Creator), Øksnes, M. (Creator), Bensing, S. (Creator), Vassiliadi, D. (Creator), Grytaas, M. (Creator), Botusan, I. (Creator), Ueland, G. (Creator), Berinder, K. (Creator), Simunkova, K. (Creator), Balomenaki, M. (Creator), Margaritopoulos, D. (Creator), Henne, N. (Creator), Crossley, R. (Creator), Russell, G. M. (Creator), Husebye, E. (Creator), Lightman, S. L. (Creator) & Upton, T. J. (Contributor), DataverseNO, 21 Jun 2023
DOI: 10.18710/5tw8yf/oihxu2, https://dataverse.no/file.xhtml?persistentId=doi:10.18710/5TW8YF/OIHXU2
Dataset
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DynamicHormoneDiagnostics_DataDictionary_2022-03-02.csv, Replication Data for: High resolution daily profiles of tissue adrenal steroids by portable automated collection
Upton, T. J. (Creator), Zavala, E. (Creator), Methlie, P. (Creator), Kämpe, O. (Creator), Tsagarakis, S. (Creator), Øksnes, M. (Creator), Bensing, S. (Creator), Vassiliadi, D. (Creator), Grytaas, M. (Creator), Botusan, I. (Creator), Ueland, G. (Creator), Berinder, K. (Creator), Simunkova, K. (Creator), Balomenaki, M. (Creator), Margaritopoulos, D. (Creator), Henne, N. (Creator), Crossley, R. (Creator), Russell, G. M. (Creator), Husebye, E. (Creator), Lightman, S. L. (Creator) & Upton, T. J. (Contributor), DataverseNO, 21 Jun 2023
DOI: 10.18710/5tw8yf/x9axnp, https://dataverse.no/file.xhtml?persistentId=doi:10.18710/5TW8YF/X9AXNP
Dataset
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HABS 3.csv, Replication Data for: High resolution daily profiles of tissue adrenal steroids by portable automated collection
Upton, T. J. (Creator), Zavala, E. (Creator), Methlie, P. (Creator), Kämpe, O. (Creator), Tsagarakis, S. (Creator), Øksnes, M. (Creator), Bensing, S. (Creator), Vassiliadi, D. (Creator), Grytaas, M. (Creator), Botusan, I. (Creator), Ueland, G. (Creator), Berinder, K. (Creator), Simunkova, K. (Creator), Balomenaki, M. (Creator), Margaritopoulos, D. (Creator), Henne, N. (Creator), Crossley, R. (Creator), Russell, G. M. (Creator), Husebye, E. (Creator), Lightman, S. L. (Creator) & Upton, T. J. (Contributor), DataverseNO, 21 Jun 2023
DOI: 10.18710/5tw8yf/9jprvy, https://dataverse.no/file.xhtml?persistentId=doi:10.18710/5TW8YF/9JPRVY
Dataset
Prizes
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Clinical Endocrinology Trust Lecture, Society for Endocrinology, Harrogate
Lightman, Stafford L (Recipient), 2013
Prize: Prizes, Medals, Awards and Grants
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Annual Meeting of European Neuroendocrine Association
Stafford L Lightman (Invited speaker)
10 Sept 2014 → 13 Sept 2014Activity: Participating in or organising an event types › Participation in conference
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International Congress of Neuroendocrinology
Stafford L Lightman (Invited speaker)
17 Aug 2014 → 20 Aug 2014Activity: Participating in or organising an event types › Participation in conference
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Colloque International: 40 Ans de Neuropeptides
Stafford L Lightman (Invited speaker)
17 Oct 2013Activity: Participating in or organising an event types › Participation in workshop, seminar, course