Projects per year
Personal profile
Research interests
Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.
We are studying the mechanisms through which the brain recognises environmental stress and disease, and the pathways it uses to initiate appropriate responses in physiological regulation and gene transcription. We have been particularly interested in the way the body utilises rhythmic activation of neuroendocrine response systems such as the hypothalamo-pituitary-adrenal axis to provide digital as well as analogue signals to glucocorticoid responsive tissues throughout the body.
In my clinical studies, we are developing novel ways of administrating glucocorticoid replacement to patients with adrenal insufficiency and have been developing systems to assess stress responses in disease and in patients undergoing surgery.
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Network
Projects
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8067 Diagnosis and Management of Thyroid Disease with U-RHYTHM - MRC CiC S Lightman
1/03/20 → 30/11/21
Project: Research
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Research output
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Co-culture of monocytes and zona fasciculata adrenal cells: An in vitro model to study the immune-adrenal cross-talk: Immune-adrenal interactions
Fudulu, D. P., Horn, G., Hazell, G. G. J., Anne-Marie Lefrancois-Martinez, Antoine Martinez, Angelini, G. D., Lightman, S. L. & Spiga, F., 15 Apr 2021, In: Molecular and Cellular Endocrinology. 526, 111195.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
Activation and expression of endogenous CREB-regulated transcription coactivators (CRTC) 1, 2 and 3 in the rat adrenal gland
Smith, L., Zhao, Z., Walker, J., Lightman, S. L. & Spiga, F., 14 Dec 2020, In: Journal of Neuroendocrinology. 33, 13 p., e12920.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.
Pooley, J., Rivers, C. A., Kilcooley, M., Paul, S. N., Cavga, A. D., Kershaw, Y. M., Muratcioglu, S., Gursoy, A., Keskin, O. & Lightman, S. L., 10 Jan 2020, In: PLoS ONE. 15, 1, 35 p., e0227520.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile
Datasets
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en.2018-00840
Lightman, S. L. (Creator), University of Bristol, 27 Dec 2018
DOI: 10.5523/bris.2h5zvknmt94i72wowv8ftoha38, http://data.bris.ac.uk/data/dataset/2h5zvknmt94i72wowv8ftoha38
Dataset
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MR_GR_interactions
Rivers, C. A. (Creator), Pooley, J. R. (Contributor) & Lightman, S. L. (Data Manager), University of Bristol, 12 Oct 2019
DOI: 10.5523/bris.2o36y65wqkjrt2auckizmff77l, http://data.bris.ac.uk/data/dataset/2o36y65wqkjrt2auckizmff77l
Dataset
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Review supplemental material - Cost of diagnosis in endocrine disease
Lightman, S. L. (Creator), Hollingworth, W. (Creator), Russell, G. M. (Creator), Chrysos, A. (Creator) & Upton, T. J. (Creator), University of Bristol, 1 Aug 2018
DOI: 10.5523/bris.dx4xevyric0020t6w8bbt774x, http://data.bris.ac.uk/data/dataset/dx4xevyric0020t6w8bbt774x
Dataset
Prizes
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Neuroendocrine Research Award Medal
Lightman, Stafford L (Recipient), 26 Apr 2014
Prize: Prizes, Medals, Awards and Grants
Activities
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Annual Meeting of European Neuroendocrine Association
Stafford L Lightman (Invited speaker)
10 Sep 2014 → 13 Sep 2014Activity: Participating in or organising an event types › Participation in conference
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International Congress of Neuroendocrinology
Stafford L Lightman (Invited speaker)
17 Aug 2014 → 20 Aug 2014Activity: Participating in or organising an event types › Participation in conference
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Colloque International: 40 Ans de Neuropeptides
Stafford L Lightman (Invited speaker)
17 Oct 2013Activity: Participating in or organising an event types › Participation in workshop, seminar, course