1988 …2020

Research output per year

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Personal profile

Research interests

Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.

We are studying the mechanisms through which the brain recognises environmental stress and disease, and the pathways it uses to initiate appropriate responses in physiological regulation and gene transcription. We have been particularly interested in the way the body utilises rhythmic activation of neuroendocrine response systems such as the hypothalamo-pituitary-adrenal axis to provide digital as well as analogue signals to glucocorticoid responsive tissues throughout the body.

In my clinical studies, we are developing novel ways of administrating glucocorticoid replacement to patients with adrenal insufficiency and have been developing systems to assess stress responses in disease and in patients undergoing surgery.

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Projects

Research Output

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

Pooley, J., Rivers, C. A., Kilcooley, M., Paul, S. N., Cavga, A. D., Kershaw, Y. M., Muratcioglu, S., Gursoy, A., Keskin, O. & Lightman, S. L., 10 Jan 2020, In : PLoS ONE. 15, 1, 35 p., e0227520.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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    Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery

    Gibbison, B., Keenan, D. M., Roelfsema, F., Evans, J., Phillips, K., Rogers, C. A., Angelini, G. D. & Lightman, S. L., 1 May 2020, In : The Journal of clinical endocrinology and metabolism. 105, 5, dgz206.

    Research output: Contribution to journalArticle (Academic Journal)

  • Dynamics of ACTH and cortisol secretion and implications for disease

    Lightman, S. L., Birnie, M. T. & Conway-Campbell, B. L., 12 Feb 2020, (Accepted/In press) In : Endocrine Reviews. bnaa002.

    Research output: Contribution to journalReview article (Academic Journal)

  • Prizes

    Neuroendocrine Research Award Medal

    Lightman, Stafford L (Recipient), 26 Apr 2014

    Prize: Prizes, Medals, Awards and Grants

    Activities

    • 15 Participation in conference
    • 7 Participation in workshop, seminar, course

    International Congress of Neuroendocrinology

    Stafford L Lightman (Invited speaker)

    17 Aug 201420 Aug 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Annual Meeting of European Neuroendocrine Association

    Stafford L Lightman (Invited speaker)

    10 Sep 201413 Sep 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Dutch-Endo-Neuro-Pyscho Meeting

    Stafford L Lightman (Invited speaker)

    29 May 201331 May 2013

    Activity: Participating in or organising an event typesParticipation in conference

    Supervised Work

    Characterisation of the stress response to heart surgery in children

    Author: Fudulu, D., 23 Jan 2020

    Supervisor: Angelini, G. (Supervisor), Lightman, S. (Supervisor), Gibbison, B. (Supervisor) & Spiga, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Characterization of dissociative anesthetics acting at the NMDA receptor site

    Author: Kang, H. H., 19 Mar 2019

    Supervisor: Lightman, S. (Supervisor) & Collingridge, G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Circadian gene expression of tryptophan hydroxylase 2 in the Dorsal and Median Raphe nuclei is altered by dysregulated glucocorticoid rhythms

    Author: Reyes Prieto, N. M., 25 Jun 2019

    Supervisor: Conway-Campbell, B. (Supervisor), Walker, J. (Supervisor) & Lightman, S. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File