Stafford L Lightman

Personal profile

Research interests

Stress related disease is a rapidly increasing feature of our society - but the mechanisms through which it causes disease are very poorly understood.

We are studying the mechanisms through which the brain recognises environmental stress and disease, and the pathways it uses to initiate appropriate responses in physiological regulation and gene transcription. We have been particularly interested in the way the body utilises rhythmic activation of neuroendocrine response systems such as the hypothalamo-pituitary-adrenal axis to provide digital as well as analogue signals to glucocorticoid responsive tissues throughout the body.

In my clinical studies, we are developing novel ways of administrating glucocorticoid replacement to patients with adrenal insufficiency and have been developing systems to assess stress responses in disease and in patients undergoing surgery.

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Projects

5 Active
20 Finished

Diagnosis and Management of Thyroid Disease with U-RHYTHM - MRC CiC S Lightman

Lightman, S. L.

1/03/20 → 28/02/21

Project: Research

8067 RSE/BBSRC Enterprise Fellowship 2019: Georgina Hazell

Lightman, S. L.

1/04/19 → 31/03/21

Project: Research

Glucocortioid Dynamics in Health and Disease

Lightman, S. L.

1/04/18 → 31/03/23

Project: Research

Research Output

326 Article (Academic Journal)
30 Conference Contribution (Conference Proceeding)
19 Review article (Academic Journal)
16 Chapter in a book
19 More

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

Pooley, J., Rivers, C. A., Kilcooley, M., Paul, S. N., Cavga, A. D., Kershaw, Y. M., Muratcioglu, S., Gursoy, A., Keskin, O. & Lightman, S. L., 10 Jan 2020, In : PLoS ONE. 15, 1, 35 p., e0227520.

Research output: Contribution to journal › Article (Academic Journal)

Open Access

File

41 Downloads (Pure)

Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery

Gibbison, B., Keenan, D. M., Roelfsema, F., Evans, J., Phillips, K., Rogers, C. A., Angelini, G. D. & Lightman, S. L., 1 May 2020, In : The Journal of clinical endocrinology and metabolism. 105, 5, dgz206.

Research output: Contribution to journal › Article (Academic Journal)

Dynamics of ACTH and cortisol secretion and implications for disease

Lightman, S. L., Birnie, M. T. & Conway-Campbell, B. L., 12 Feb 2020, (Accepted/In press) In : Endocrine Reviews. bnaa002.

Research output: Contribution to journal › Review article (Academic Journal)

Datasets

en.2018-00840

Lightman, S. L. (Creator), University of Bristol, 27 Dec 2018

DOI: 10.5523/bris.2h5zvknmt94i72wowv8ftoha38, http://data.bris.ac.uk/data/dataset/2h5zvknmt94i72wowv8ftoha38

Dataset

Review supplemental material - Cost of diagnosis in endocrine disease

Lightman, S. L. (Creator), Hollingworth, W. (Creator), Russell, G. M. (Creator), Chrysos, A. (Creator) & Upton, T. J. (Creator), University of Bristol, 1 Aug 2018

DOI: 10.5523/bris.dx4xevyric0020t6w8bbt774x, http://data.bris.ac.uk/data/dataset/dx4xevyric0020t6w8bbt774x

Dataset

Glucocorticoid receptor tethered mineralocorticoid receptors increase glucocorticoid-induced transcriptional responses

Lightman, S. L. (Creator), Conway-Campbell, B. L. (Creator), Rivers, C. A. (Creator), Pooley, J. R. (Creator) & Rogers, M. (Creator), University of Bristol, 5 Dec 2018

DOI: 10.5523/bris.28jhb462ss43d2ujuwwnwl30lb, http://data.bris.ac.uk/data/dataset/28jhb462ss43d2ujuwwnwl30lb

Dataset