1988 …2020

Research output per year

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Research Output

2020

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

Pooley, J., Rivers, C. A., Kilcooley, M., Paul, S. N., Cavga, A. D., Kershaw, Y. M., Muratcioglu, S., Gursoy, A., Keskin, O. & Lightman, S. L., 10 Jan 2020, In : PLoS ONE. 15, 1, 35 p., e0227520.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
41 Downloads (Pure)

Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery

Gibbison, B., Keenan, D. M., Roelfsema, F., Evans, J., Phillips, K., Rogers, C. A., Angelini, G. D. & Lightman, S. L., 1 May 2020, In : The Journal of clinical endocrinology and metabolism. 105, 5, dgz206.

Research output: Contribution to journalArticle (Academic Journal)

Dynamics of ACTH and cortisol secretion and implications for disease

Lightman, S. L., Birnie, M. T. & Conway-Campbell, B. L., 12 Feb 2020, (Accepted/In press) In : Endocrine Reviews. bnaa002.

Research output: Contribution to journalReview article (Academic Journal)

Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH

Smith, L. I. F., Victoria Huang, Mark Olah, Loc Trinh, Ying Liu, Hazell, G., Conway-Campbell, B., Zhao, Z., Antoine Martinez, Anne-Marie Lefrancois-Martinez, Lightman, S., Spiga, F. & Greti Aguilera, 1 Jan 2020, In : Molecular and Cellular Endocrinology. 499, 11 p., 110612.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
105 Downloads (Pure)
Open Access
File
19 Downloads (Pure)

The Peacock study: feasibility of the dynamic characterisation of the paediatric hypothalamic-pituitary-adrenal function during and after cardiac surgery

Fudulu, D. P., Angelini, G. D., Papadopoulou, F. F., Evans, J., Walker-Smith, T. A. F., Kema, I., Van Fassen, M., Stoica, S., Caputo, M., Lightman, S. & Gibbison, B. J. J., 25 May 2020, In : BMC Cardiovascular Disorders. 20, 1, 8 p., 245 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Downloads (Pure)
2019

Continuous Free Cortisol Profiles - Circadian Rhythms in Healthy Men

Bhake, R. C., Kluckner, V., Stassen, H., Russell, G. M., Leendertz, J., Stevens, K., Linthorst, A. C. E. & Lightman, S. L., Dec 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 5935-5947 13 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Continuous Free Cortisol Profiles in Healthy Men - Validation of Microdialysis Method

Bhake, R., Russell, G. M., Kershaw, Y., Stevens, K., Zaccardi, F., Warburton, V. E. C., Linthorst, A. C. E. & Lightman, S. L., 16 Sep 2019, In : The Journal of clinical endocrinology and metabolism. dgz002.

Research output: Contribution to journalArticle (Academic Journal)

Dynamics of ACTH-Mediated Regulation of Gene Transcription in ATC1 and ATC7 Adrenal Zona Fasciculata Cell Lines

Hazell, G., Horn, G., Lightman, S. L. & Spiga, F., 15 Feb 2019, In : Endocrinology. 160, 3, p. 587-604 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
178 Downloads (Pure)

Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages: individual participant meta-analysis of five cohorts

Gardner, M., Lightman, S., Kuh, D., Comijs, H., Deeg, D., Gallacher, J., Geoffroy, M-C., Kivimaki, M., Kumari, M., Power, C., Hardy, R., Richards, M. & Ben-Shlomo, Y., 14 Mar 2019, In : Scientific Reports. 9, 1, 13 p., 4555.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
127 Downloads (Pure)

Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses

Rivers, C. A., Rogers, M. F., Stubbs, F. E., Conway-Campbell, B. L., Lightman, S. L. & Pooley, J. R., 1 May 2019, In : Endocrinology. 160, 5, p. 1044-1056 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
167 Downloads (Pure)

Growth hormone secretion, fatigue and quality of life after childhood traumatic brain injury

Daskas, N., Sharples, P. M., Likeman, M., Lightman, S. L. & Crowne, E. C., Oct 2019, In : European Journal of Endocrinology. 181, 3, p. 331-338 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Improving glucocorticoid replacement profiles in adrenal insufficiency

Choudhury, S., Lightman, S. & Meeran, K., 6 May 2019, In : Clinical Endocrinology. 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
11 Downloads (Pure)

Mathematical Modelling of Endocrine Systems

Zavala, E., Wedgwood, K. C. A., Voliotis, M., Tabak, J., Spiga, F., Lightman, S. & Tsaneva-Atanasova, K., Apr 2019, In : Trends in Endocrinology and Metabolism. 30, 4, p. 244-257 14 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
3 Citations (Scopus)
112 Downloads (Pure)

Mechanisms in endocrinology: Does circadian and ultradian glucocorticoid exposure affect the brain?

Kalafatakis, K., Russell, G. M. & Lightman, S. L., Feb 2019, In : European Journal of Endocrinology. 180, 2, p. R73-R89 17 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
2 Citations (Scopus)
46 Downloads (Pure)

Role of the posterodorsal medial amygdala in predator odour stress‐induced puberty delay in female rats

Li, X. F., Adekunbi, D. A., Alobaid, H. M., Li, S., Pilot, M., Lightman, S. L. & O'Byrne, K. T., 1 Jun 2019, In : Journal of Neuroendocrinology. 31, 6, 12 p., e12719.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
157 Downloads (Pure)

Seasonal variation in antidepressant prescriptions, environmental light and web queries for seasonal affective disorder

Lansdall-Welfare, T., Lightman, S. & Cristianini, N., 1 Aug 2019, In : British Journal of Psychiatry. 215, 2, p. 481-484 4 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

The human stress response

Russell, G. & Lightman, S., 1 Sep 2019, In : Nature Reviews Endocrinology. 15, 9, p. 525-534 10 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
21 Citations (Scopus)
333 Downloads (Pure)

The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach

Voliotis, M., Li, X. F., De Burgh, R., Lass, G., Lightman, S. L., O'Byrne, K. T. & Tsaneva-Atanasova, K., 4 Dec 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 49, p. 9738-9747 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
17 Downloads (Pure)

Thirty years of neuroendocrinology: technological advances pave the way for molecular discovery

Stubbs, F., Conway-Campbell, B. & Lightman, S., 22 Mar 2019, In : Journal of Neuroendocrinology. 31, 3, 10 p., e12653.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
69 Downloads (Pure)

Utilization of the Allen Gene Expression Atlas to gain further insight into glucocorticoid physiology in the adult mouse brain

Kalafatakis, K., Giannakeas, N., Lightman, S., Charalampopoulos, I., Russell, G., Tsipouras, M. & Tzallas, A., 27 Jul 2019, In : Neuroscience Letters. 706, p. 194-200 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
29 Downloads (Pure)
2018

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

Turton, S., Myers, J. F. M., Mick, I., Colasanti, A., Venkataraman, A., Durant, C., Waldman, A., Brailsford, A., Parkin, M. C., Dawe, G., Rabiner, E. A., Gunn, R. N., Lightman, S. L., Nutt, D. J. & Lingford-Hughes, A., 25 Jun 2018, In : Molecular Psychiatry. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
196 Downloads (Pure)

Corticosteroids and other anti-Inflammatory strategies in pediatric heart surgery: a national survey of practice

Fudulu, D., Schadenberg, A. W. L., Gibbison, B., Jenkins, I. A., Lightman, S., Angelini, G. & Stoica, S., May 2018, In : World Journal for Pediatric and Congenital Heart Surgery. 9, 3, p. 289-293 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
279 Downloads (Pure)

Corticosteroids in Pediatric Heart Surgery: Myth or Reality

Fudulu, D. P., Gibbison, B., Upton, T., Stoica, S. C., Caputo, M., Lightman, S. & Angelini, G. D., 20 Apr 2018, In : Frontiers in Pediatrics. 6, 16 p., 112.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
6 Citations (Scopus)
232 Downloads (Pure)

Diurnal variations of psychometric indicators in Twitter content

Dzogang, F., Lightman, S. & Cristianini, N., 20 Jun 2018, In : PLoS ONE. 13, 6, 18 p., e019700.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
246 Downloads (Pure)

Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice

Adekunbi, D. A., Li, X. F., Lass, G., Shetty, K., Adegoke, O. A., Yeo, S. H., Colledge, W. H., Lightman, S. L. & O'Byrne, K. T., 1 Mar 2018, In : Journal of Neuroendocrinology. 30, 3, 9 p., e12572.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Citations (Scopus)
216 Downloads (Pure)

OR37 ligand exposure reduces cFos expression in the pvn of the hypothalamus, following open field exposure, without affecting behavioural measures of anxiety

Purawijaya, D., Davies, J. R., Robinson, E. S. J., Mendl, M. T., Lightman, S. L. & Brennan, P. A., 1 Mar 2018, OR37 ligands exposure reduces activation of the paraventricular nucleus of hypothalamus following anxiogenic behavioural tests. (Chemical Senses).

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Prophylactic corticosteroids for paediatric heart surgery with cardiopulmonary bypass

Gibbison, B., Villalobos Lizardi, J. C., Avilés Martínez, K. I., Fudulu, D. P., Medina Andrade, M. A., Pérez-Gaxiola, G., Schadenberg, A. W. L., Stoica, S. C., Lightman, S. L., Angelini, G. D. & Reeves, B. C., 30 Aug 2018, In : Cochrane Database of Systematic Reviews. 2018, 8, 14 p., CD013101.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
110 Downloads (Pure)

Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity

Stirrat, L. I., Walker, J. J., Stryjakowska, K., Jones, N., Homer, N. Z. M., Andrew, R., Norman, J. E., Lightman, S. L. & Reynolds, R. M., 1 Apr 2018, In : Clinical Endocrinology. 88, 4, p. 592-600 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
197 Downloads (Pure)

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

Gjerstad, J. K., Lightman, S. L. & Spiga, F., 15 May 2018, In : Stress. p. 1-14 14 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
20 Citations (Scopus)

SKOV3 cells containing a truncated ARID1a protein have a restricted genome-wide response to glucocorticoids

Stubbs, F. E., Birnie, M. T., Biddie, S. C., Lightman, S. L. & Conway-Campbell, B. L., 5 Feb 2018, In : Molecular and Cellular Endocrinology. 461, p. 226-235 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
240 Downloads (Pure)

Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity

Ingram, R., Kang, H. H., Lightman, S., Jane, D., Bortolotto, Z., Collingridge, G., Lodge, D. & Volianskis, A., 6 Jun 2018, In : Neuropharmacology.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
174 Downloads (Pure)

The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology

Flynn, B. P., Conway-Campbell, B. L. & Lightman, S. L., 1 Jun 2018, In : Annales d'Endocrinologie. 79, 3, p. 112-114 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
223 Downloads (Pure)

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

Kalafatakis, K., Russell, G. M., Harmer, C. J., Munafo, M. R., Marchant, N., Wilson, A., Brooks, J. C., Durant, C., Thakrar, J., Murphy, P., Thai, N. J. & Lightman, S. L., 24 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. E4091-E4100 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
21 Citations (Scopus)
365 Downloads (Pure)
2017

Circadian mood variations in Twitter content

Cristianini, N., Dzogang, F. & Lightman, S., 2017, In : Brain and Neuroscience Advances.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
241 Downloads (Pure)

Corticosteroids in septic shock: a systematic review and network meta-analysis

Gibbison, B., Lopez-Lopez, J. A., Higgins, J., Miller, T., Angelini, G., Lightman, S. & Annane, D., 28 Mar 2017, In : Critical Care. 21, 1, 3 p., 78.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
43 Citations (Scopus)
327 Downloads (Pure)

Dynamic responses of the adrenal steroidogenic regulatory network

Spiga, F., Zavala, E., Walker, J., Zhao, Z., Terry, J. & Lightman, S., 1 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. E6466-E6474 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
202 Downloads (Pure)

Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis

Hannen, R., Udeh-Momoh, C., Upton, J., Wright, M., Michael, A., Gulati, A., Rajpopat, S., Clayton, N., Halsall, D., Burrin, J., Flower, R., Sevilla, L., Latorre, V., Frame, J., Lightman, S., Perez, P. & Philpott, M., 1 Aug 2017, In : Journal of Investigative Dermatology. p. 1630-1637 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
122 Downloads (Pure)

Genome-wide identification of basic helix-loop helix and NF-1 motifs underlying GR binding sites in male rat hippocampus

Pooley, J. R., Flynn, B. P., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R. L., Hager, G. L., Lightman, S. L. & Conway-Campbell, B. L., 13 Feb 2017, In : Endocrinology. 158, 5, p. 1486–1501 27 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
226 Downloads (Pure)

Optimal Sampling Frequency of Serum Cortisol Concentrations After Cardiac Surgery

Powell, B., Nason, G. P., Angelini, G. D., Lightman, S. L. & Gibbison, B., Oct 2017, In : Critical Care Medicine. 45, 10, p. e1103-e1104 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
File
5 Citations (Scopus)
254 Downloads (Pure)

Role of amygdala kisspeptin in pubertal timing in female rats

Adekunbi, D. A., Li, X. F., Li, S., Adegoke, O. A., Iranloye, B. O., Morakinyo, A. O., Lightman, S. L., Taylor, P. D., Poston, L. & O'Byrne, K. T., 28 Aug 2017, In : PLoS ONE. 12, 8, 15 p., e0183596.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
190 Downloads (Pure)

Seasonal variation in collective mood via Twitter content and medical purchases

Cristianini, N., Dzogang, F., Lightman, S. & Goulding, J., 2017, Advances in Intelligent Data Analysis XVI.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

Freeman, D., Sheaves, B., Goodwin, G. M., Yu, L-M., Nickless, A., Harrison, P. J., Emsley, R., Luik, A. I., Foster, R. G., Wadekar, V., Hinds, C., Gumley, A., Jones, R., Lightman, S., Jones, S., Bentall, R., Kinderman, P., Rowse, G., Brugha, T., Blagrove, M. & 22 others, Gregory, A. M., Fleming, L., Walklet, E., Glazebrook, C., Davies, E. B., Hollis, C., Haddock, G., John, B., Coulson, M., Fowler, D., Pugh, K., Cape, J., Moseley, P., Brown, G., Hughes, C., Obonsawin, M., Coker, S., Watkins, E., Schwannauer, M., MacMahon, K., Siriwardena, A. N. & Espie, C. A., 1 Oct 2017, In : Lancet Psychiatry. 4, 10, p. 749-758 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
114 Citations (Scopus)
315 Downloads (Pure)

The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D. J., Lightman, S., Vgontzas, A. & Van Cauter, E., 1 Feb 2017, In : Endocrine Reviews. 38, 1, p. 3-45 43 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
102 Citations (Scopus)
302 Downloads (Pure)

Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo

George, C. L., Birnie, M. T., Flynn, B., Kershaw, Y., Lightman, S. L. & Conway-Campbell, B. L., 5 Jan 2017, In : Molecular and Cellular Endocrinology. 439, p. 46-53 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
269 Downloads (Pure)
2016

A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A. A., Diaz, A. P., Boos, G., Lin, K., Linhares, M. N., Nunes, J. C., Quevedo, J., Bortolotto, Z. A., Markowitsch, H. J., Lightman, S. L. & Walz, R., Dec 2016, In : Translational Psychiatry. 6, 12, 9 p., e986.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
220 Downloads (Pure)

Circadian and Ultradian Glucocorticoid Rhythmicity: Implications for the Effects of Glucocorticoids on Neural Stem Cells and Adult Hippocampal Neurogenesis

Fitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J. & Lightman, S., 2016, In : Frontiers in Neuroendocrinology. 41, p. 44-58 15 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

Open Access
File
30 Citations (Scopus)
192 Downloads (Pure)

Cortisol and CBG: Getting cortisol to the right place at the right time

Henley, D., Lightman, S. & Carrell, R., Oct 2016, In : Pharmacology and Therapeutics. 166, p. 128-135 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
176 Downloads (Pure)

Dynamics of the HPA axis: A systems modelling approach

Terry, JR., Walker, J., Spiga, F. & Lightman, S., 2016, Computational Neuroendocrinology.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book