1988 …2020

Research output per year

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Research Output

2016

Cortisol and CBG: Getting cortisol to the right place at the right time

Henley, D., Lightman, S. & Carrell, R., Oct 2016, In : Pharmacology and Therapeutics. 166, p. 128-135 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
185 Downloads (Pure)

Dynamics of the HPA axis: A systems modelling approach

Terry, JR., Walker, J., Spiga, F. & Lightman, S., 2016, Computational Neuroendocrinology.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Effects of the pattern of glucocorticoid replacement on neural processing, emotional reactivity and well-being in healthy male individuals: study protocol for a randomised controlled trial

Kalafatakis, K. G., Russell, G. M., Harmer, C. J., Munafo, M. R., Marchant, N. J., Wilson, A., Brooks, J. C. W., Thai, N. J., Ferguson, S. G., Stevenson, K., Durant, C. F., Schmidt, K. & Lightman, S. L., 22 Jan 2016, In : Trials. 17, 1, 17 p., 44.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
343 Downloads (Pure)

Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light

Pilorz, V., Tam, SK., Hughes, S., Pothecary, CA., Jagannath, A., Hankins, MW., Bannerman, DM., Lightman, S., Vyazovskiy, VV., Nolan, PM., Foster, RG. & Pierson, SN., 8 Jun 2016, In : PLoS Biology. 14, 6, 24 p., e1002482.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
58 Citations (Scopus)
233 Downloads (Pure)

Rhythms within rhythms: the importance of oscillations for glucocorticoid hormones

Lightman, S., 2016, A Time for Metabolism and Hormones. p. 87-99

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
21 Citations (Scopus)
293 Downloads (Pure)

The role of hippocampal NMDA receptors in long-term emotional responses following muscarinic receptor activation

Hoeller, A. A., Costa, A. P. R., Bicca, M. A., Matheus, F. C., Lach, G., Spiga, F., Lightman, S. L., Walz, R., Collingridge, G. L., Bortolotto, Z. A. & De Lima, T. C. M., 21 Jan 2016, In : PLoS ONE. 11, 1, 18 p., e0147293.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
240 Downloads (Pure)
2015

60 YEARS OF NEUROENDOCRINOLOGY: Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies

Spiga, F., Walker, J. J., Gupta, R., Terry, J. R. & Lightman, S. L., Aug 2015, In : Journal of Endocrinology. 226, 2, p. T55-T66 12 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
24 Citations (Scopus)
278 Downloads (Pure)

A simple complex case: Restoration of circadian cortisol activity

Bhake, R. & Lightman, S., 2015, In : AIMS Medical Science. 2, 3, p. 182-185

Research output: Contribution to journalArticle (Academic Journal)

Control of Body Weight by Eating Behavior in Children

Zandian, M., Bergh, C., Ioakimidis, I., Esfandiari, M., Shield, J., Lightman, S., Leon, M. & Södersten, P., 19 Oct 2015, In : Frontiers in Pediatrics. 3, 6 p., 89.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
261 Downloads (Pure)

Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery

Gibbison, B., Spiga, F., Walker, J. J., Russell, G. M., Zhao, Z., Stevenson, K., Henley, DE., Angelini, G. D. & Lightman, S. L., Apr 2015, In : Critical Care Medicine. 43, 4, p. 791-800 10 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Dynamics of adrenal glucocorticoid steroidogenesis in health and disease

Spiga, F. & Lightman, S. L., 15 Jun 2015, In : Molecular and Cellular Endocrinology. 408, p. 227-34 8 p.

Research output: Contribution to journalReview article (Academic Journal)

26 Citations (Scopus)

Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort

Dénes, J., Swords, F., Rattenberry, E., Stals, K., Owens, M., Cranston, T., Xekouki, P., Moran, L., Kumar, A., Wassif, C., Fersht, N., Baldeweg, S. E., Morris, D., Lightman, S., Agha, A., Rees, A., Grieve, J., Powell, M., Boguszewski, C. L., Dutta, P. & 31 others, Thakker, R. V., Srirangalingam, U., Thompson, C. J., Druce, M., Higham, C., Davis, J., Eeles, R., Stevenson, M., O'Sullivan, B., Taniere, P., Skordilis, K., Gabrovska, P., Barlier, A., Webb, S. M., Aulinas, A., Drake, W. M., Bevan, J. S., Preda, C., Dalantaeva, N., Ribeiro-Oliveira, A., Garcia, I. T., Yordanova, G., Iotova, V., Evanson, J., Grossman, A. B., Trouillas, J., Ellard, S., Stratakis, C. A., Maher, E. R., Roncaroli, F. & Korbonits, M., Mar 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 3, p. E531-41

Research output: Contribution to journalArticle (Academic Journal)

Inactivation of corticotropin-releasing hormone-induced insulinotropic role by high-altitude hypoxia

Hao, K., Kong, F-P., Gao, Y-Q., Tang, J-W., Chen, J., Evans, A. M., Lightman, S. L., Chen, X-Q. & Du, J-Z., Mar 2015, In : Diabetes. 64, 3, p. 785-95 11 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Rapid intra-adrenal feedback regulation of glucorticoid synthesis

Walker, J., Spiga, F., Gupta, R., Zhao, Z., Lightman, S. & Terry, J., 6 Jan 2015, In : Journal of the Royal Society Interface. 12, 102, p. 20140875 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Relative Importance of the Arcuate and Anteroventral Periventricular Kisspeptin Neurons in Control of Puberty and Reproductive Function in Female Rats

Hu, M. H., Li, X. F., McCausland, B., Li, S. Y., Gresham, R., Kinsey-Jones, J. S., Gardiner, J. V., Sam, A. H., Bloom, S. R., Poston, L., Lightman, S. L., Murphy, K. G. & O'Byrne, K. T., Jul 2015, In : Endocrinology. 156, 7, p. 2619-31 13 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Reversible biological adaptations in obesity

Södersten, P., Bergh, C., Shield, J. & Lightman, S., May 2015, In : Lancet Diabetes and Endocrinology. 3, 5, p. 314

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
42 Citations (Scopus)

The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats

Li, XF., Minghan, H., Hanley, B. P., Lin, Y., Poston, L., Lightman, S. & O'Byrne, K. T., Oct 2015, In : Endocrinology. 156, 10, p. 3725-36 12 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients

Rockliff, H. E., Lightman, S. L., Rhidian, E., Buchanan, H., Gordon, U. & Vedhara, K., 29 Mar 2014, In : Human Reproduction Update. 20, 4, p. 594-613 20 p.

Research output: Contribution to journalReview article (Academic Journal)

Can side effects of steroid treatments be minimized by the temporal aspects of delivery method?

Russell, G. M. & Lightman, S. L., 26 Sep 2014, In : Expert opinion on drug safety. 13, 11, p. 1501-13

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Cardio-metabolic consequences of glucocorticoid replacement: relevance of ultradian signalling

Henley, D. E. & Lightman, S. L., May 2014, In : Clinical Endocrinology. 80, 5, p. 621-8 8 p.

Research output: Contribution to journalReview article (Academic Journal)

Critical illness-related corticosteroid insufficiency in cardiogenic shock.

Gibbison, B. & Lightman, S. L., 2014, In : British Journal of Anaesthesia. 112, 4, p. 756-7 10.1093/bja/aeu065.

Research output: Contribution to journalLetter (Academic Journal)

1 Citation (Scopus)

Effects of 7.5% carbon dioxide inhalation on anxiety and mood in cigarette smokers

Attwood, A. S., Ataya, A. F., Bailey, J. E., Lightman, S. L. & Munafò, M. R., 24 Apr 2014, In : Journal of Psychopharmacology. 28, 8, p. 763-772 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
263 Downloads (Pure)

Hippocampus remodeling by chronic stress accompanied by GR, proteasome and caspase-3 overexpression

Orlovsky, M. A., Dosenko, V. E., Spiga, F., Skibo, G. G. & Lightman, S. L., 17 Dec 2014, In : Brain Research. 1593, p. 83-94 12 p.

Research output: Contribution to journalArticle (Academic Journal)

HPA axis-Rhythms

Spiga, F., Walker, J. J., Terry, J. R. & Lightman, S. L., 2014, In : Comprehensive Physiology. 4, 3, p. 1273-98

Research output: Contribution to journalReview article (Academic Journal)

259 Downloads (Pure)

Neurokinin B receptor antagonism decreases luteinising hormone pulse frequency and amplitude and delays puberty onset in the female rat

Li, S. Y., Li, X. F., Hu, M. H., Shao, B., Poston, L., Lightman, S. L. & O'Byrne, K. T., Aug 2014, In : Journal of Neuroendocrinology. 26, 8, p. 521-7 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Neurokinin B signaling in the female rat: a novel link between stress and reproduction

Grachev, P., Li, X. F., Hu, M. H., Li, S. Y., Millar, R. P., Lightman, S. L. & O'Byrne, K. T., Jul 2014, In : Endocrinology. 155, 7, p. 2589-601 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Overexpression of corticotropin releasing factor in the central nucleus of the amygdala advances puberty and disrupts reproductive cycles in female rats

Li, X. F., Hu, M. H., Li, S. Y., Geach, C., Hikima, A., Rose, S., Greenwood, M. P., Greenwood, M., Murphy, D., Poston, L., Lightman, S. L. & O'Byrne, K. T., Oct 2014, In : Endocrinology. 155, 10, p. 3934-44 11 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters

Farmer, A. D., Coen, S. J., Kano, M., Naqvi, H., Paine, P. A., Scott, S. M., Furlong, P. L., Lightman, S. L., Knowles, C. H. & Aziz, Q., Jan 2014, In : Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 26, 1, p. 139-48 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Steroid hormones in 2013: Glucocorticoids: timing, binding and environment

Lightman, S. L. & George, C. L., Feb 2014, In : Nature Reviews Endocrinology. 10, 2, p. 71-2 2 p.

Research output: Contribution to journalReview article (Academic Journal)

Subcutaneous pulsatile glucocorticoid replacement therapy

Russell, G. M., Durant, C., Ataya, A., Papastathi, C., Bhake, R., Woltersdorf, W. & Lightman, S., 16 Apr 2014, In : Clinical Endocrinology. 81, 2, p. 289-93

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

The importance of dynamic signalling for endocrine regulation and drug development: relevance for glucocorticoid hormones

Lightman, S. & Terry, J. R., Jul 2014, In : Lancet Diabetes and Endocrinology. 2, 7, p. 593-9 7 p.

Research output: Contribution to journalArticle (Academic Journal)

The Interface of Stress and the HPA Axis in Behavioural Phenotypes of Mental Illness

Baumeister, D., Lightman, S. L. & Pariante, C. M., 22 Mar 2014, In : Current topics in behavioral neurosciences. 18, p. 13-24 12 p.

Research output: Contribution to journalArticle (Academic Journal)

2013

Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus

Whitehead, G., Jo, J., Hogg, E. L., Piers, T., Kim, D-H., Seaton, G., Seok, H., Bru-Mercier, G., Son, G. H., Regan, P. L., Hildebrandt, L., Waite, E., Kim, B-C., Kerrigan, T. L., Kim, K., Whitcomb, D. J., Collingridge, G. L., Lightman, S. L. & Cho, K., Dec 2013, In : Brain. 136, 12, p. 3753-3765 13 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Adaptive changes in basal and stress-induced HPA activity in lactating and post-lactating female rats

Windle, R. J., Wood, S. A., Kershaw, Y. M., Lightman, S. L. & Ingram, C. D., Feb 2013, In : Endocrinology. 154, 2, p. 749-61 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Automated 24-hours sampling of subcutaneous tissue free cortisol in humans

Bhake, R. C., Leendertz, J. A., Linthorst, A. C. E. & Lightman, S. L., Apr 2013, In : Journal of Medical Engineering and Technology. 37, 3, p. 180-4 5 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Constant light disrupts the circadian rhythm of steroidogenic proteins in the rat adrenal gland

Park, S. Y., Walker, J. J., Johnson, N. W., Zhao, Z., Lightman, S. L. & Spiga, F., 22 May 2013, In : Molecular and Cellular Endocrinology. 371, 1-2, p. 114-123 10 p.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery.

Gibbison, B., Angelini, G. D. & Lightman, S. L., Sep 2013, In : British Journal of Anaesthesia. 111, 3, p. 347-60 10.1093/bja/aet077.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis

Gardner, M. P., Lightman, S. L., Aihie Sayer, A., Cooper, C., Cooper, R., Deeg, D., Ebrahim, S. B. J., Gallacher, J., Kivimaki, M., Kumari, M., Kuh, D., Martin, R. M., Peeters, G., Ben-Shlomo, Y. & the HALCyon Study Team, Jan 2013, In : Psychoneuroendocrinology. 38, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
38 Citations (Scopus)
265 Downloads (Pure)

GHRH receptor-targeted botulinum neurotoxin selectively inhibits pulsatile GH secretion in male rats

Leggett, J., Harper, E., Waite, E., Marks, P., Martinez, A. & Lightman, S., Sep 2013, In : Endocrinology. 154, 9, p. 3305-18 14 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation

Choe, H. K., Kim, H-D., Park, S. H., Lee, H-W., Park, J. Y., Seong, J. Y., Lightman, S. L., Son, G. H. & Kim, K., 2 Apr 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5677-5682 6 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

The role of mineralocorticoid receptor function in treatment-resistant depression

Juruena, M. F., Pariante, C. M., Papadopoulos, A. S., Poon, L., Lightman, S. & Cleare, A. J., Dec 2013, In : Journal of Psychopharmacology. 27, 12, p. 1169-79 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Transcriptional regulation of episodic glucocorticoid secretion

Liu, Y., Smith, L. I., Huang, V., Poon, V., Coello, A., Olah, M., Spiga, F., Lightman, S. L. & Aguilera, G., 22 May 2013, In : Molecular and Cellular Endocrinology. 371, 1-2, p. 62-70 9 p.

Research output: Contribution to journalReview article (Academic Journal)

2012

Activation of the Orexin 1 Receptor Is a Critical Component of CO(2)-Mediated Anxiety and Hypertension but not Bradycardia

Johnson, PL., Samuels, BC., Fitz, SD., Lightman, SL., Lowry, CA. & Shekhar, A., Mar 2012, In : Neuropsychopharmacology.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Acute Glucocorticoid Administration Rapidly Suppresses Basal and Stress-Induced Hypothalamo-Pituitary-Adrenal Axis Activity

Andrews, MH., Wood, SA., Windle, RJ., Lightman, SL. & Ingram, CD., Jan 2012, In : Endocrinology. 153(1), p. 200 - 211 12 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Characterizing Dynamic Interactions between Ultradian Glucocorticoid Rhythmicity and Acute Stress Using the Phase Response Curve

Rankin, J., Walker, J. J., Windle, R., Lightman, S. L. & Terry, J. R., 21 Feb 2012, In : PLoS ONE. 7, 2, 7 p., e30978.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)
1 Downloads (Pure)

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain

Qian, X., Droste, S. K., Lightman, S. L., Reul, J. M. H. M. & Linthorst, A. C. E., Sep 2012, In : Endocrinology. 153, 9, p. 4346-4353 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
76 Citations (Scopus)
466 Downloads (Pure)