1988 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2012

Dynamic regulation of glucocorticoid signalling in health and disease

Biddie, SC., Conway-Campbell, BL. & Lightman, SL., Mar 2012, In : Rheumatology. 51, 3, p. 403 - 412 10 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)

Effects of childhood stress: Hardwired or reversible?

Turner-Cobb, JM., Jessop, D. & Lightman, S., 2012, In : Biologist. 59, 4, p. 31-35

Research output: Contribution to journalArticle (Academic Journal)

GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats

Grachev, P., Li, X. F., Lin, Y. S., Hu, M. H., Elsamani, L., Paterson, S. J., Millar, R. P., Lightman, S. L. & O'Byrne, K. T., 2012, In : PLoS ONE. 7, 9, p. e44344

Research output: Contribution to journalArticle (Academic Journal)

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei - serpentine gateways to neuroendocrine homeostasis

Hazell, G. G. J., Hindmarch, C. C. T., Pope, G. R., Roper, J., Lightman, S. L., Murphy, D., O'Carroll, A-M. & Lolait, S. J., Jan 2012, In : Frontiers in Neuroendocrinology. 33, 1, p. 45 - 66 22 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Maternal mood and neuroendocrine programming: effects of time of exposure and sex

Vedhara, K., Metcalfe, C., Brant, HD., Crown, A., Northstone, K., Dawe, KL., Lightman, S. & Davey Smith, G., 2012, In : Journal of Neuroendocrinology.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Molecular dynamics of ultradian glucocorticoid receptor action

Conway-Campbell, BL., Pooley, J., Hager, GL. & Lightman, SL., Jan 2012, In : Molecular and Cellular Endocrinology. 30;348(2), p. 383 - 393 11 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

NFκB and glucocorticoid receptor activity in steroid resistance

Dawson, C., Dhanda, A., Conway-Campbell, B., Dimambro, A., Lightman, S. & Dayan, C., Feb 2012, In : Journal of Receptor and Signal Transduction Research. 32, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Normalizing Eating Behavior Reduces Body Weight and Improves Gastrointestinal Hormonal Secretion in Obese Adolescents

Galhardo, J., Hunt, LP., Lightman, SL., Sabin, MA., Bergh, C., Sodersten, P. & Shield, JPH., Feb 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 2, 9 p., E193.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Suppression of the GnRH pulse generator by neurokinin B involves a κ-opioid receptor-dependent mechanism

Grachev, P., Li, X. F., Kinsey-Jones, J. S., di Domenico, A. L., Millar, R. P., Lightman, S. L. & O'Byrne, K. T., Oct 2012, In : Endocrinology. 153, 10, p. 4894-904 11 p.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat

Kinsey-Jones, JS., Grachev, P., Li, XF., Lin, YS., Milligan, SR., Lightman, SL. & O'Byrne, KT., Jan 2012, In : Endocrinology. 153(1), p. 307 - 315 9 p.

Research output: Contribution to journalArticle (Academic Journal)

85 Citations (Scopus)

The origin of glucocorticoid hormone oscillations

Walker, J. J., Spiga, F., Waite, E., Zhao, Z., Kershaw, Y., Terry, J. R. & Lightman, S. L., 2012, In : PLoS Biology. 10, 6, e1001341.

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

The role of GABAergic signalling in stress-induced suppression of GnRH pulse generator frequency in female rats

Lin, YS., Li, XF., Shao, B., Hu, MH., Goundry, AL., Jeyaram, A., Lightman, SL. & O'Byrne, KT., Mar 2012, In : Journal of Neuroendocrinology. 24(3), p. 477 - 488 12 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Ultradian corticosterone secretion is maintained in the absence of circadian cues

Waite, E. J., McKenna, M. A., Kershaw, Y. M., Walker, J. J., Cho, K., Piggins, H. D. & Lightman, S. L., 2012, In : European Journal of Neuroscience. 36, p. 3142-3150 9 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)
2011

ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion

Spiga, F., Waite, EJ., Liu, Y., Kershaw, YM., Aguilera, G. & Lightman, SL., Apr 2011, In : Endocrinology. 152(4), p. 1448 - 1457

Research output: Contribution to journalArticle (Academic Journal)

69 Citations (Scopus)
38 Citations (Scopus)

Changes in the maternal hypothalamic-pituitary-adrenal axis during the early puerperium may be related to the postpartum 'blues'

O'Keane, V., Lightman, S., Patrick, K., Marsh, M., Papadopoulos, A. S., Pawlby, S., Seneviratne, G., Taylor, A. & Moore, R., Nov 2011, In : Journal of Neuroendocrinology. 23, 11, p. 1149-55 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice

Mason, B. L., Thomas, S. A., Lightman, S. L. & Pariante, C. M., Oct 2011, In : Psychoneuroendocrinology. 36, 9, p. 1351-60 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding

Spiga, F., Knight, DM., Droste, S-K., Conway-Campbell, BL., Kershaw, YM., MacSweeney, CP., Thomson, FJ., Craighead, M., Peeters, BW. & Lightman, SL., Feb 2011, In : Journal of Psychopharmacology. 25(2), p. 211 - 221

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Diurnal cortisol patterns are associated with physical performance in the Caerphilly Prospective Study

Gardner, M. P., Lightman, S. L., Gallacher, J., Hardy, R., Kuh, D., Ebrahim, S., Bayer, A., Ben-Shlomo, Y. & the HALCyon Study Team, Dec 2011, In : International Journal of Epidemiology. 40, 6, p. 1693 - 1702 10 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Epigenetics: a lasting impression?

Biddie, S. C. & Lightman, S. L., Feb 2011, In : Journal of Neuroendocrinology. 23, 2, p. 194-5 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Hypothalamic-pituitary-adrenal-axis dysregulation over twenty years predicts physical performance in the Caerphilly Prospective Study

Gardner, MP., Lightman, SL., Gallacher, J., Hardy, R., Kuh, D., Ebrahim, S. B. J., Bayer, T. & Ben-Shlomo, Y., 2 Feb 2011, South West Public Health Annual Conference.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Increased pituitary-adrenal activation and shortened gestation in a sample of depressed pregnant women: a pilot study

O'Keane, V., Lightman, S., Marsh, M., Pawlby, S., Papadopoulos, A. S., Taylor, A., Moore, R. & Patrick, K., Apr 2011, In : Journal of Affective Disorders. 130, 1-2, p. 300-5 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Induction of c-Fos in 'panic/defence'-related brain circuits following brief hypercarbic gas exposure

Johnson, P. L., Fitz, S. D., Hollis, J. H., Moratalla, R., Lightman, S. L., Shekhar, A. & Lowry, C. A., Jan 2011, In : Journal of Psychopharmacology. 25, 1, p. 26-36 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Neonatal programming by immunological challenge: effects on ovarian function in the adult rat

Wu, X-Q., Li, X-F., Ye, B., Popat, N., Milligan, S. R., Lightman, S. L. & O'Byrne, K. T., Feb 2011, In : Reproduction. 141, 2, p. 241-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

New insights into corticosteroid-binding globulin and glucocorticoid delivery

Henley, D. E. & Lightman, S. L., 28 Apr 2011, In : Neuroscience. 180, p. 1-8 8 p.

Research output: Contribution to journalReview article (Academic Journal)

Testosterone, Cortisol:Testosterone ratio and physical performance in later life: results from the Caerphilly Prospective Study (CaPS)

Gardner, MP., Davey Smith, G., Lightman, SL., Gallacher, J., Kuh, D., Ebrahim, S. B. J., Bayer, T. & Ben-Shlomo, Y., Aug 2011, IEA World Congress of Epidemiology. BMJ Publishing Group, Vol. 65. p. A186 - A186 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its co-regulatory molecules CBP/P300 during ultradian ligand treatment

Conway-Campbell, BL., George, CL., Pooley, JR., Knight, DM., Norman, MR., Hager, G. L. & Lightman, SL., Jun 2011, In : Molecular Endocrinology. 25, p. 944 - 954 11 p.

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)

The impact of breastfeeding on mothers’ attentional sensitivity towards infant distress

Pearson, RM., Lightman, SL. & Evans, J., 2011, In : Infant Behavior and Development. 34, p. 200 - 2005

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

The role of the bed nucleus of the stria terminalis in stress-induced inhibition of pulsatile luteinising hormone secretion in the female rat

Li, X. F., Lin, Y. S., Kinsey-Jones, J. S., Milligan, S. R., Lightman, S. L. & O'Byrne, K. T., Jan 2011, In : Journal of Neuroendocrinology. 23, 1, p. 3-11 9 p.

Research output: Contribution to journalArticle (Academic Journal)

The role of the medial and central amygdala in stress-induced suppression of pulsatile LH secretion in female rats

Lin, Y., Li, X., Lupi, M., Kinsey-Jones, J. S., Shao, B., Lightman, S. & O'Byrne, K. T., Feb 2011, In : Endocrinology. 152, 2, p. 545-55 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding

Biddie, SC., John, S., Sabo, PJ., Thurman, RE., Schiltz, RL., Johnson, TA., Sung, MH., Trump, S., Lightman, SL., Vinson, C., Stamatoyannopoulos, JA. & Hager, GL., 8 Jul 2011, In : Molecular Cell. 43 , 1, p. 145 - 155 11 p.

Research output: Contribution to journalArticle (Academic Journal)

267 Citations (Scopus)

Transcription factor interactions in genomic nuclear receptor function

George, CL., Lightman, SL. & Biddie, SC., Aug 2011, In : Epigenomics. 3(4), p. 471 - 485 15 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)
2010

An investigation into the effects of social evaluation on cardiovascular and endocrine responses to the CO2 stress test in humans

Vedhara, K., Brant, H. D., Alexiou, A., Petrie, KJ., Miles, JNV. & Lightman, S. L., 2010, In : Stress. 13, 3, p. 195-202

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Corticotrophin-releasing factor alters the timing of puberty in the female rat

Kinsey-Jones, J. S., Li, X. F., Knox, A. M. I., Lin, Y. S., Milligan, S. R., Lightman, S. L. & O'Byrne, K. T., Feb 2010, In : Journal of Neuroendocrinology. 22, 2, p. 102-9 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Depressive symptoms in early pregnancy disrupt attentional processing of infant emotion

Pearson, RM., Cooper, RM., Penton-Voak, IS., Lightman, SL. & Evans, J., Apr 2010, In : Psychological Medicine. 40, 4, p. 621 - 631 11 p.

Research output: Contribution to journalArticle (Academic Journal)

71 Citations (Scopus)

Encoding and decoding mechanisms of pulsatile hormone secretion

Walker, JJ., Terry, JR., Tsaneva-Atanasova, KT., Armstrong, SP., McArdle, CA. & Lightman, SL., Jun 2010, (Accepted/In press).

Research output: Working paperWorking paper and Preprints

File
50 Citations (Scopus)
505 Downloads (Pure)

Encoding and Decoding Mechanisms of Pulsatile Hormone Secretion

Walker, JJ., Terry, JR., Tsaneva-Atanasova, KT., Armstrong, SP., McArdle, CA. & Lightman, SL., Dec 2010, In : Journal of Neuroendocrinology. 22, p. 1226 - 1238 13 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the clock gene period 1 in rat hippocampus

Conway-Campbell, BL., Sarabdjitsingh, R. A., McKenna, MA., Pooley, JR., Kershaw, YM., Meijer, O. C., De Kloet, E. R. & Lightman, SL., Oct 2010, In : Journal of Neuroendocrinology. 22, p. 1093 - 1100 8 p.

Research output: Contribution to journalArticle (Academic Journal)

94 Citations (Scopus)

Novel corticosteroid-binding globulin variant that lacks steroid binding activity

Perogamvros, I., Underhill, C., Henley, D. E., Hadfield, K. D., Newman, W. G., Ray, D. W., Lightman, S. L., Hammond, G. L. & Trainer, P. J., Oct 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 10, p. E142-50

Research output: Contribution to journalArticle (Academic Journal)

Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis

Walker, JJ., Terry, JR. & Lightman, SL., Jun 2010, In : Proceedings of the Royal Society B: Biological Sciences. 277, p. 1627 - 1633 7 p.

Research output: Contribution to journalArticle (Academic Journal)

142 Citations (Scopus)

Rapid glucocorticoid receptor mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy male

Russell, GM., Henley, DE., Leendertz, JA., Douthwaite, JA., Wood, SA., Stevens, A., Woltersdorf, WW., Peeters, B., Ruigt, G., White, A., Veldhuis, J. & Lightman, SL., 28 Apr 2010, In : Journal of Neuroscience. 30, 17, p. 6106 - 6115 10 p.

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)

Recovery from disrupted ultradian glucocorticoid rhythmicity reveals a dissociation between hormonal and behavioural stress responsiveness

Sarabdjitsingh, RA., Spiga, F., Oitzl, MS., Kershaw, YM., Meijer, OC., Lightman, SL. & de Kloet, ER., Aug 2010, In : Journal of Neuroendocrinology. 22(8), p. 862 - 871 10 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Reduced stress responsiveness in pregnancy: relationship with pattern of forebrain c-fos mRNA expression.

Windle, R., Wood, S., Kershaw, Y., Lightman, S. & Ingram, C., 2010, In : Brain Research. 1358, p. 102-109

Research output: Contribution to journalArticle (Academic Journal)

Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic

Atkinson, HC., Leggett, JD., Wood, SA., Castrique, ES., Kershaw, YM. & Lightman, SL., Aug 2010, In : Endocrinology. 151 (8), p. 3720 - 3727 8 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Stress responsiveness varies over the ultradian glucocorticoid cycle in a brain-region-specific manner

Sarabdjitsingh, R. A., Conway-Campbell, BL., Leggett, JD., Waite, EJ., Meijer, O. C., de Kloet, E. R. & Lightman, SL., Sep 2010, In : Endocrinology. 151, p. 5369 - 5379 11 p.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)

Temperature-responsive release of cortisol from its binding globulin: A protein thermocouple

Cameron, G., Henley, DE., Carrell, R., Zhou, A., Clarke, AR. & Lightman, SL., Oct 2010, In : Journal of Clinical Endocrinology and Metabolism. 95 (10), p. 4689 - 4695 8 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)

The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

Lightman, SL. & Conway-Campbell, BL., Oct 2010, In : Nature Reviews Neuroscience. 11, p. 710 - 718 9 p.

Research output: Contribution to journalArticle (Academic Journal)

213 Citations (Scopus)