1988 …2020

Research output per year

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Research Output

2010

The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment

Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S. & Pariante, C. M., Nov 2010, In : Psychoneuroendocrinology. 35, 10, p. 1486-91 6 p.

Research output: Contribution to journalArticle (Academic Journal)

2009

Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression

Gardner, K. L., Hale, M. W., Lightman, S. L., Plotsky, P. M. & Lowry, C. A., 11 Dec 2009, In : Brain Research. 1305, p. 47-63 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus

Gardner, K. L., Hale, M. W., Oldfield, S., Lightman, S. L., Plotsky, P. M. & Lowry, C. A., 10 Nov 2009, In : Neuroscience. 163, 4, p. 991-1001 11 p.

Research output: Contribution to journalArticle (Academic Journal)

A glucocorticoid sensitive biphasic rhythm of testosterone secretion

Waite, EJ., Kershaw, YM., Spiga, F. & Lightman, SL., Sep 2009, In : Journal of Neuroendocrinology. 21, p. 737 - 741

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

A role for the medial preoptic area in CGRP-induced suppression of pulsatile LH secretion in the female rat

Li, X. F., Kinsey-Jones, J. S., Bowe, J. E., Wilkinson, E. S., Brain, S. D., Lightman, S. L. & O'Byrne, K. T., May 2009, In : Stress. 12, 3, p. 259-67 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Blockade of the V(1b) receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic-pituitary-adrenal axis activity

Spiga, F., Harrison, L., Wood, SA., Knight, DM., MacSweeney, CP., Thomson, FJ., Craighead, M. & Lightman, SL., Mar 2009, In : Journal of Endocrinology. 200(3), p. 273 - 283

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Development of an automated blood sampling system for use in humans

Henley, DE., Leendertz, JA., Russell, GM., Wood, SA., Taheri, S., Woltersdorf, WW. & Lightman, SL., Apr 2009, In : Journal of Medical Engineering and Technology. 33(3), p. 199 - 208 10 p.

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Distinct, time-dependent effects of voluntary exercise on circadian and ultradian rhythms and stress responses of free corticosterone in the rat hippocampus

Droste, S-K., Collins, A., Lightman, SL., Linthorst, ACE. & Reul, JMHM., 1 Sep 2009, In : Endocrinology. 150, 9, p. 4170 - 4179 10 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)
17 Citations (Scopus)

Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat

Kinsey-Jones, J. S., Li, X. F., Knox, A. M. I., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., Milligan, S. R., Lightman, S. L. & O'Byrne, K. T., Jan 2009, In : Journal of Neuroendocrinology. 21, 1, p. 20-9 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor

Spiga, F., Harrison, L., MacSweeney, CP., Thomson, FJ., Craighead, M. & Lightman, SL., Mar 2009, In : Journal of Endocrinology. 200(3), p. 285 - 291 7 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
57 Citations (Scopus)

Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioural responses in rats

Lowry, C. A., Hale, M. W., Plant, A., Windle, R. J., Shanks, N., Wood, S. A., Ingram, C. D., Renner, K. J., Lightman, S. L. & Summers, C. H., May 2009, In : Stress. 12, 3, p. 225-39 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy

Henley, DE., Russell, GM., Douthwaite, JA., Wood, SA., Buchanan, F., Gibson, R., Woltersdorf, W., Catteral, J. & Lightman, SL., 1 Nov 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 11, p. 4234 - 4242 9 p.

Research output: Contribution to journalArticle (Academic Journal)

81 Citations (Scopus)

Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat

Li, X-F., Kinsey-Jones, J. S., Cheng, Y., Knox, A. M. I., Lin, Y., Petrou, N. A., Roseweir, A., Lightman, S. L., Milligan, S. R., Millar, R. P. & O'Byrne, K. T., 16 Dec 2009, In : PLoS ONE. 4, 12, p. e8334

Research output: Contribution to journalArticle (Academic Journal)

Neonatal lipopolysaccharide exposure delays puberty and alters hypothalamic Kiss1 and Kiss1r mRNA expression in the female rat

Knox, A. M. I., Li, X. F., Kinsey-Jones, J. S., Wilkinson, E. S., Wu, X. Q., Cheng, Y. S., Milligan, S. R., Lightman, S. L. & O'Byrne, K. T., Aug 2009, In : Journal of Neuroendocrinology. 21, 8, p. 683-9 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Organizational role for pubertal androgens on adult hypothalamic-pituitary-adrenal sensitivity to testosterone in the male rat

Evuarherhe, O., Leggett, JD., Waite, EJ., Kershaw, YM., Atkinson, HC. & Lightman, SL., Jun 2009, In : Journal of Physiology. 587, p. 2977 - 2985 9 p.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis

Terry, JR., Lightman, SL. & Walker, JJ., 8 Oct 2009.

Research output: Working paperWorking paper and Preprints

File
403 Downloads (Pure)

Plasma apelin levels in obstructive sleep apnea and the effect of continuous positive airway pressure therapy

Henley, D. E., Buchanan, F., Gibson, R., Douthwaite, J. A., Wood, S. A., Woltersdorf, W. W., Catterall, J. R. & Lightman, S. L., Oct 2009, In : Journal of Endocrinology. 203, 1, p. 181-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance

Juruena, M. F., Pariante, C. M., Papadopoulos, A. S., Poon, L., Lightman, S. & Cleare, A. J., Apr 2009, In : British Journal of Psychiatry. 194, 4, p. 342-9 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Reversal of the hypothalamo-pituitary-adrenal response to oestrogens around puberty

Evuarherhe, O., Leggett, JD., Waite, EJ., Kershaw, YM. & Lightman, SL., Aug 2009, In : Journal of Endocrinology. 202 (2), p. 279 - 285 7 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

That warm fuzzy feeling: brain serotonergic neurons and the regulation of emotion

Lowry, C. A., Lightman, S. L. & Nutt, D. J., Jun 2009, In : Journal of Psychopharmacology. 23, 4, p. 392-400 9 p.

Research output: Contribution to journalReview article (Academic Journal)

The significance of dysregulated basal glucocorticoid pulsatility in affective disorders: Chapter in: Understanding Depression

Conway-Campbell, B., CC, W. & Lightman, S., 2009, Understanding Depression. Pariante, C. (ed.). Oxford University Press, p. 77-90 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

48 Citations (Scopus)

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

Stavreva, D. A., Wiench, M., John, S., Conway-Campbell, BL., McKenna, MA., Pooley, JR., Johnson, T. A., Voss, T. C., Lightman, SL. & Hager, G. L., Sep 2009, In : Nature Cell Biology. 11, p. 1093 - 1102 10 p.

Research output: Contribution to journalArticle (Academic Journal)

244 Citations (Scopus)

Women with diarrhoea-predominant irritable bowel syndrome show an increased pressure response to 35% carbon dioxide stress challenge

Shufflebotham, J., Wetherall, MA., Hince, D., Hood, SD., Lightman, SL., Nutt, DJ., Probert, C. & Potokar, JP., Jan 2009, In : Stress. 12(1), p. 30 - 36 7 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)
2008

A pilot exploration of heart rate variability and salivary cortisol responses to compassion-focused imagery.

Rockliff, H., Gilbert, P., McEwan, K., Lightman, S. & Glover, D., 2008, In : Clinical Neuropsychiatry: Journal of Treatment Evaluation. 5, 3, p. 132-139

Research output: Contribution to journalArticle (Academic Journal)

Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor

Atkinson, H. C., Wood, S. A., Castrique, E. S., Kershaw, Y. M., Wiles, C. C. R. & Lightman, S. L., Jun 2008, In : AJP - Endocrinology and Metabolism. 294, 6, p. E1011-22

Research output: Contribution to journalArticle (Academic Journal)

Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress

Droste, S-K., de Groote, L., Atkinson, HC., Lightman, SL., Reul, JMHM. & Linthorst, ACE., 1 Jul 2008, In : Endocrinology. 149, 7, p. 3244 - 3253 10 p.

Research output: Contribution to journalArticle (Academic Journal)

200 Citations (Scopus)

Genetic background influences the behavioural and molecular consequences of neurokinin-1 receptor knockout

McCutcheon, JE., Fisher, AS., Guzdar, E., Wood, SA., Lightman, SL. & Hunt, SP., Feb 2008, In : European Journal of Neuroscience. 27 (3), p. 683 - 690

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Interaction of the glucocorticoid receptor with the chromatin landscape

John, S., Sabo, P., Johnson, TA., Sung, M-H., Biddie, SC., Lightman, SL., Voss, TC., Davis, SR., Meltzer, PS., Stamatoyannopoulos, JA. & Hager, GL., 14 Mar 2008, In : Molecular Cell. 29, 5, p. 611 - 624 14 p.

Research output: Contribution to journalArticle (Academic Journal)

230 Citations (Scopus)

The HPA axis in major depression: classical theories and new developments

Pariante, C. M. & Lightman, S. L., 2008, In : Trends in Neurosciences. 31, 9, p. 464-8 5 p.

Research output: Contribution to journalArticle (Academic Journal)

987 Citations (Scopus)

The Minder Brain (Book Review)

Lightman, SL., May 2008, In : Journal of Anatomy. 212, p. 702 - 702

Research output: Contribution to journalArticle (Academic Journal)

The neuroendocrinology of stress: a never ending story

Lightman, S. L., Jun 2008, In : Journal of Neuroendocrinology. 20, 6, p. 880-4 5 p.

Research output: Contribution to journalReview article (Academic Journal)

The role of corticotrophin-releasing hormone receptors in the calcitoinin gene-related peptide-induced suppression of pulsatile luteinising hormone secretion in the female rat

Bowe, JE., Li, XF., Kinsey-Jones, JS., Brain, SD., Lightman, SL. & O'Bryne, KT., 2008, In : Stress. 11, p. 312 - 319

Research output: Contribution to journalArticle (Academic Journal)

The significance of glucocorticoid pulsatility

Lightman, SL., Wiles, CCR., Atkinson, HC., Henley, DE., Russell, GM., Leendertz, JA., McKenna, MA., Spiga, F., Wood, SA. & Conway-Campbell, BL., Apr 2008, In : European Journal of Pharmacology. 583, p. 255 - 262 8 p.

Research output: Contribution to journalReview article (Academic Journal)

146 Citations (Scopus)

Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress

Chen, J., Young, S., Subburaju, S., Sheppard, J., Kiss, A., Atkinson, H., Wood, S., Lightman, S., Serradeil-Le Gal, C. & Aguilera, G., Dec 2008, In : Annals of the New York Academy of Sciences. 1148, p. 349-59 11 p.

Research output: Contribution to journalArticle (Academic Journal)

2007

An investigation of hypothalamic-pituitary-adrenal axis hyperactivity in anorexia nervosa: the role of CRH and AVP

Connan, F., Lightman, SL., Landau, S., Wheeler, M., Treasure, J. & Campbell, IC., Jan 2007, In : Journal of Pyschiatric Research. 41 (1-2), p. 131 - 143

Research output: Contribution to journalArticle (Academic Journal)

56 Citations (Scopus)

Early molecular events in the hippocampus of rats with streptozotocin-induced diabetes

Orlovsky, MA., Spiga, F., Lebed, YV., Skibo, GG. & Lightman, SL., 2007, In : Neurophysiology. 39 (6), p. 435 - 438

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion

Spiga, F., Harrison, L., Wood, SA., Atkinson, HC., MacSweeney, CP., Thomson, FJ., Craighead, M., Grassie, M. & Lightman, SL., 2007, In : Journal of Neuroendocrinology.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release

Spiga, F., Harrison, L., Wood, SA., MacSweeney, CP., Thomson, FJ., Craighead, M., Grassie, M. & Lightman, SL., Feb 2007, In : Journal of Endocrinology. 196 (2), p. 323 - 330 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior

Lowry, CA., Hollis, JH., de Vries, A., Pan, B., Brunet, LR., Hunt, JRF., Paton, JFR., Van Kampen, E., Knight, DM., Evans, AK., Rook, GAW. & Lightman, SL., May 2007, In : Neuroscience. 146 (2), p. 756 - 772 17 p.

Research output: Contribution to journalArticle (Academic Journal)

96 Citations (Scopus)

Neonatal lipopolysaccharide exposure exacerbates stress-induced suppression of luteinizing hormone pulse frequency in adulthood

Li, X. F., Kinsey-Jones, J. S., Knox, A. M. I., Wu, X. Q., Tahsinsoy, D., Brain, S. D., Lightman, S. L. & O'Byrne, K. T., Dec 2007, In : Endocrinology. 148, 12, p. 5984-90 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Relationship of early childhood illness with adult cortisol in the Barry Caerphilly Growth (BCG) cohort

Vedhara, K., Miles, J., Crown, AL., McCarthy, A., Shanks, NM., Davies, D., Lightman, SL., Davey Smith, G. & Ben-Shlomo, Y., Sep 2007, In : Psychoneuroendocrinology. 32 (8-10), p. 865 - 873 9 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice

Yau, JL., Noble, J., Thomas, S., Kerwin, R., Morgan, PE., Lightman, SL., Seckl, JR. & Pariante, CM., Dec 2007, In : Neuropsychopharmacology. 32 (12), p. 2520 - 2529

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

The stress response in laparoscopic urological surgery

Ayres, BE., Thomas, F., Zacharowski, KD., Lightman, SL. & Persad, R., Jun 2007, In : BJU International. 99 (6), p. 1331 - 1332 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Toll-Like Receptor 9 Expression in Murine and Human Adrenal Glands and Possible Implications during Inflammation

Tran, N., Koch, A., Berkels, R., Boehm, O., Zacharowski, PA., Baumgarten, G., Knuefermann, P., Schott, M., Kanczkowski, W., Bornstein, SR., Lightman, SL. & Zacharowski, KD., Jul 2007, In : Journal of Clinical Endocrinology and Metabolism. 92 (7), p. 2773 - 2783 11 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Ultradian Rhythms

Lightman, SL., 2007, Encyclopedia of Stress. Academic Press, Vol. 3. p. 791 - 793

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2006

Corticosteroids and the cardiovascular response to stress: a pilot study of the 35% CO2 challenge in Addison's disease

Kaye, JM. & Lightman, SL., Sep 2006, In : Clinical Endocrinology. 65 (3), p. 282 - 286 5 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat

Li, XF., Bowe, JE., Kinsey-Jones, JS., Brain, SD., Lightman, SL. & O'Byrne, KT., Aug 2006, In : Journal of Neuroendocrinology. 18 (8), p. 602 - 610 9 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)