1988 …2020

Research output per year

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Research Output

2006

Different responses to dexamethasone and prednisolone in the same depressed patients

Juruena, MF., Cleare, AJ., Papadopoulos, AS., Poon, L., Lightman, SL. & Pariante, CM., Dec 2006, In : Psychopharmacology. 189, p. 225 - 235

Research output: Contribution to journalArticle (Academic Journal)

93 Citations (Scopus)

Diurnal variation in the responsiveness of the hypothalamic-pituitary-adrenal axis of the male rat to noise stress

Atkinson, HC., Wood, SA., Kershaw, YM., Bate, E. & Lightman, SL., Jul 2006, In : Journal of Neuroendocrinology. 18 (7), p. 526 - 533 8 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)

Do corticosteroids damage the brain?

Herbert, J., Goodyer, IM., Grossman, A., Hastings, MH., de Kloet, ER., Lightman, SL., Lupien, SJ., Roozendaal, B. & Seckl, JR., Jun 2006, In : Journal of Neuroendocrinology. 18 (6), p. 393 - 411 19 p.

Research output: Contribution to journalArticle (Academic Journal)

250 Citations (Scopus)

Gonadal steroid modulation of stress-induced hypothalamo-pituitary-adrenal activity and anxiety behavior: role of central oxytocin

Windle, RJ., Gamble, LE., Kershaw, YM., Wood, SA., Lightman, SL. & Ingram, CD., May 2006, In : Endocrinology. 147 (5), p. 2423 - 2431 9 p.

Research output: Contribution to journalArticle (Academic Journal)

73 Citations (Scopus)

Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons

Spiga, F., Lightman, SL., Shekhar, A. & Lowry, CA., Apr 2006, In : Neuroscience. 138 (4), p. 1265 - 1276 12 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)

Lipopolysaccharide has indomethacin-sensitive actions on Fos expression in topographically organized subpopulations of serotonergic neurons

Hollis, JH., Evans, AK., Bruce, KPE., Lightman, SL. & Lowry, CA., Nov 2006, In : Brain, Behavior, and Immunity. 20 (6), p. 569 - 577 9 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)

Micro RNAs and osmotic regulation

Uney, JB. & Lightman, SL., Oct 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103 (42), p. 15278 - 15279 2 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Neuroendocrine and behavioural responses to CO2 inhalation in central versus peripheral autonomic failure

Kaye, JM., Young, TM., Mathias, CJ., Watson, L. & Lightman, SL., Apr 2006, In : Clinical Autonomic Research. 16, p. 121 - 129 9 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Patterns of exposure to glucocorticoid receptor ligand

Lightman, SL., Dec 2006, In : Biochemical Society Transactions. 34 (Pt 6), p. 1117 - 1118

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

The four-dimensional stress test: Psychological, sympathetic-adrenal-medullary, parasympathetic and hypothalamic-pituitary-adrenal responses following inhalation of 35% CO2

Wetherell, M., Crown, AL., Lightman, SL., Miles, J., Kaye, J. & Vedhara, K., Jul 2006, In : Psychoneuroendocrinology. 31 (6), p. 736 - 747 12 p.

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)

Tryptophan metabolism in the central nervous system: medical implications

Ruddick, JP., Evans, A., Nutt, DJ., Lightman, SL., Rook, GA. & Lowry, CA., Aug 2006, In : Expert Reviews in Molecular Medicine. 8 (20), p. 1 - 27 27 p.

Research output: Contribution to journalArticle (Academic Journal)

210 Citations (Scopus)
2005

Acute hypercarbic gas exposure reveals functionally distinct subpopulations of serotonergic neurons in rats

Johnson, P., Hollis, JH., Moratalla, R., Lightman, SL. & Lowry, CA., Jul 2005, In : Journal of Psychopharmacology. 19 (4), p. 327 - 341 16 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)

A new test for autonomic cardiovascular and neuroendocrine responses in diabetes mellitus: evidence for early vagal dysfunction

Kaye, JM., Corrall, RJM. & Lightman, SL., Jan 2005, In : Diabetologia. 48 (1), p. 180 - 186 7 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Are tuberomammillary histaminergic neurons involved in CO2 mediated arousal?

Johnson, P., Moratalla, R., Lightman, SL. & Lowry, CA., 2005, In : Experimental Neurology. 193(1), p. 228 - 233 6 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Can neurobiology explain the relationship between stress and disease?

Lightman, SL., 2005, Biopsychosocial Medicine - an integrated approach to understanding illness. White, P. (ed.). Chapter 6 ed. Oxford University Press, p. 103 - 111 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide

de Vries, A., Paton, JFR., Lightman, SL. & Lowry, CA., 14 Oct 2005, In : Autonomic Neuroscience: Basic and Clinical. 123, p. 62 - 75 14 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Cortisol, testosterone and coronary heart disease: prospective evidence from the Caerphilly study

Davey Smith, G., Ben-Shlomo, Y., Beswick, AD., Yarnell, J., Lightman, SL. & Elwood, PC., 19 Jul 2005, In : Circulation. 112 (3), p. 332 - 340 9 p.

Research output: Contribution to journalArticle (Academic Journal)

236 Citations (Scopus)

Early life experience alters behavior during social defeat: focus on serotonergic systems

Gardner, K., Thrivikraman, KV., Lightman, SL., Plotsky, PM. & Lowry, CA., Mar 2005, In : Neuroscience. 136 (1), p. 181 - 191 11 p.

Research output: Contribution to journalArticle (Academic Journal)

124 Citations (Scopus)

Effect of calcitonin gene-related peptide on gonadotrophin-releasing hormone mRNA expression in GT1-7 cells

Kinsey-Jones, JS., Li, XF., Bowe, JE., Brain, SD., Lightman, SL. & O'Byrne, KT., 2005, In : Journal of Neuroendocrinology. 17, p. 541 - 544 4 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
24 Citations (Scopus)

Organizational role for testosterone and estrogen on adult hypothalamic-pituitary-adrenal axis activity in the male rat

Seale, JV., Wood, SA., Atkinson, HC., Lightman, SL. & Harbuz, MS., Apr 2005, In : Endocrinology. 146 (4), p. 1973 - 1982 10 p.

Research output: Contribution to journalArticle (Academic Journal)

86 Citations (Scopus)

Postnatal masculinization alters the HPA axis phenotype in the adult female rat

Seale, JV., Wood, SA., Atkinson, HC., Harbuz, MS. & Lightman, SL., Feb 2005, In : Journal of Physiology. 563 (1), p. 265 - 274 10 p.

Research output: Contribution to journalArticle (Academic Journal)

56 Citations (Scopus)

Role of corticotropin-releasing factor receptor-2 in stress-induced suppression of pulsatile luteinizing hormone secretion in the rat

Li, XF., Bowe, JE., Lightman, SL. & O'Byrne, KT., 2005, In : Endocrinology. 146, p. 318 - 322

Research output: Contribution to journalArticle (Academic Journal)

61 Citations (Scopus)

Shift work and breast cancer: report of an expert meeting 12 November 2004

Lightman, SL., Shuker, L. & Harrison, P., 2005, In : IEH Web Report W23. May, p. 1 - 20 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Why is the management of glucocorticoid deficiency still controversial: a review of the literature

Crown, AL. & Lightman, SL., 2005, In : Clinical Endocrinology. 63, p. 483 - 492 10 p.

Research output: Contribution to journalArticle (Academic Journal)

101 Citations (Scopus)
2004

Acute carbon dioxide exposure in healthy adults: evaluation of a novel means of investigating the stress response

Kaye, J., Buchanan, F., Kendrick, A., Johnson, P., Lowry, CA., Bailey, JE., Nutt, DJ. & Lightman, SL., 2004, In : Journal of Neuroendocrinology. 16, p. 256 - 264 (3).

Research output: Contribution to journalArticle (Academic Journal)

89 Citations (Scopus)

Adrenalectomy further suppresses the NT-3 mRNA response to traumatic brain injury but this effect is not reversed with corticosterone

Grundy, PL., Patel, N., Harbuz, MS., Lightman, SL. & Sharples, PM., 2004, In : Molecular Brain Research. 120, p. 188 - 192 (2).

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
79 Citations (Scopus)

Atypical depression in growth hormone deficient adults, and the beneficial effects of growth hormone treatment on depression and quality of life

Mahajan, TA., Crown, AL., Checkley, S., Farmer, A. & Lightman, SL., 2004, In : European Journal of Endocrinology. 151, p. 325 - 332

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Cortisol, pulsatility and its role in stress regulation and health

Young, E., Abelson, J. & Lightman, SL., 2004, In : Frontiers in Neuroendocrinology. 25, p. 69 - 76

Research output: Contribution to journalArticle (Academic Journal)

220 Citations (Scopus)

Differential effects of repeated restraint stress on pulsatile lutenizing hormone secretion in female Fischer, Lewis and Wistar rats

Li, XF., Edward, J., Mitchell, JC., Shao, B., Bowes, JE., Coen, CW., Lightman, SL. & O'Byrne, KT., 2004, In : Journal of Neuroendocrinology. 16(7), p. 620 - 627 8 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers

Pariante, CM., Papadopoulos, AS., Poon, L., Cleare, AJ., Checkley, SA., English, J., Kerwin, RW. & Lightman, SL., 2004, In : Psychopharmacology. 177, p. 200 - 206

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)
158 Citations (Scopus)

Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats

Seale, JV., Wood, SA., Atkinson, HC., Bate, E., Lightman, SL., Ingram, CD., Jessop, DS. & Harbuz, MS., 2004, In : Journal of Neuroendocrinology. 16(6), p. 516 - 524 9 p.

Research output: Contribution to journalArticle (Academic Journal)

161 Citations (Scopus)

Integration of systemic and visceral sensory information by medullary catecholaminergic systems during peripheral inflammation

Hollis, JH., Lightman, SL. & Lowry, CA., 2004, In : Annals of the New York Academy of Sciences. 1018, p. 71 - 75

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Mineralocorticoid and glucocorticoid receptors and their differential effects on memory performance in people with Addison's disease

Tytherleigh, MY., Vedhara, K. & Lightman, SL., Jul 2004, In : Psychoneuroendocrinology. 29 (6), p. 712 - 723 12 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)

Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity

Windle, RJ., Kershaw, YM., Shanks, NM., Wood, SA., Lightman, SL. & Ingram, CD., 2004, In : Journal of Neuroscience. 24, p. 2974 - 2982

Research output: Contribution to journalArticle (Academic Journal)

298 Citations (Scopus)

Responses to the 35% CO2 challenge in postpartum women

Kaye, J., Soothill, PW., Hunt, M. & Lightman, SL., 2004, In : Clinical Endocrinology. 61, p. 582 - 588 7 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Stress-induced suppression of the gonadotropin releasing hormone pulse generator in the female rat: a novel neural action for calcitonin gene-related peptide

Li, XF., Bowe, JE., Mitchell, JC., Brain, SD., Lightman, SL. & O'Byrne, KT., 2004, In : Endocrinology. 145, p. 1556 - 1563

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)
2003

Altered glucocorticoid immunoregulation in treatment resistant depression

Bauer, ME., Papadopoulos, A., Poon, L., Perks, P., Lightman, SL., Checkley, S. & Shanks, NM., 2003, In : Psychoneuroendocrinology. 28, p. 48 - 65

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)

Anatomical and functional evidence for a stress-responsive, monoamine-accumulating area in the dorsomedial hypothalamus of adult rat brain

Lowry, CA., Plant, A., Shanks, NM., Ingram, CD. & Lightman, SL., Jan 2003, In : Hormones and Behavior. 43 (1), p. 254 - 262 9 p.

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)

A neurodevelopmental model for anorexia nervosa

Connan, F., Campbell, JC., Katzman, M., Lightman, SL. & Treasure, J., 2003, In : Physiology and Behavior. 79, p. 13 - 24

Research output: Contribution to journalArticle (Academic Journal)

171 Citations (Scopus)

An investigation into the relationship between salivary cortisol, stress, anxiety, and depression

Vedhara, K., Miles, J., Bennett, PN., Plummer, S., Tallon, D., Brooks, E., Gale, L., Munnock, K., Schreiber-Kounine, C., Fowler, C., Lightman, SL., Sammon, A., Rayter, Z. & Farndon, J., Feb 2003, In : Biological Psychology. 62 (2), p. 89 - 96 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Chronic stress accelerates atherosclerosis in the apolipoprotein E deficient mouse

Kumari, M., Grahame-Clarke, C., Shanks, N., Marmot, M., Lightman, SL. & Vallance, P., 2003, In : Stress. 6(4), p. 297 - 299

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Does the brain noradrenaline network mediate the effects of the CO2 challenge?

Bailey, JE., Argyropoulos, SV. & Lightman, SL., 2003, In : Journal of Psychopharmacology. 17(3), p. 252 - 259

Research output: Contribution to journalArticle (Academic Journal)

Enhancement of Antibody Responses to Influenza Vaccination in Elderly Carers of Dementia Patients Following a Cognitive-Behavioural Stress Management Intervention

Vedhara, K., Bennett, PD., Clark, S., Lightman, SL., Shaw, S., Perks, PA., Hunt, MA., Philip, J., Tallon, D., Murphy, P., Jones, R., Wilcock, GK. & Shanks, NM., 2003, In : Psychotherapy and Psychosomatics. 72, p. 245 - 252

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)

Hypothalamo-pituitary-adrenal axis dysregulation in patients with rheumatoid arthritis after the dexamethasone/corticotrophin releasing factor test

Harbuz, MS., Korendowych, E., Jessop, DS., Crown, AL., Lightman, SL. & Kirwan, JR., Jul 2003, In : Journal of Endocrinology. 178 (1), p. 55 - 60 6 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Management of Pituitary Tumors: The Clinician's Practical Guide

Powell, MP., Lightman, SL. & Laws, ER., 2003, Humana Press. 318 p.

Research output: Book/ReportEdited book

Molecular defects in the pathogenesis of pituitary tumours

Levy, A. & Lightman, SL., 2003, In : Frontiers in Neuroendocrinology. 24, p. 94 - 127

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)