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Research Output

2020

A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia

Jones, H. J., Martin, D., Lewis, S. J., Davey Smith, G., O'Donovan, M. C., Owen, M. J., Walters, J. T. R. & Zammit, S., 24 Jun 2020, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Downloads (Pure)

A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder.

Sullivan, S. A., Kounali, D-Z., Cannon, M., David, A. S., Fletcher, P., Holmans, P. A., Jones, H., Jones, P. B., Linden, D. E. J., Lewis, G. H., Owen, M. J., O'Donovan, M. C., Rammos, A., Thompson, A., Wolke, D. & Zammit, S., 7 Jan 2020, In : American Journal of Psychiatry. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Change in the relationship between drinking alcohol and risk of violence among adolescents and young adults: A nationally representative longitudinal study

Zammit, S., 11 Mar 2020, (Accepted/In press) Oxford University Press Blog.

Research output: Contribution to specialist publicationArticle (Specialist Publication)

Open Access
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4 Downloads (Pure)

Common Mechanisms for Type 2 Diabetes and Psychosis: Findings from a Prospective Birth Cohort

Perry, B., Jones, H. J., Richardson, T. G., Zammit, S., Wareham, N. J., Lewis, G., Jones, P. B. & Khandaker, G., 19 Aug 2020, In : Schizophrenia Research. 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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31 Downloads (Pure)

Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence

European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) High Risk Study Group, 26 Aug 2020, In : JAMA Psychiatry.

Research output: Contribution to journalArticle (Academic Journal)

Disturbed sleep connects symptoms of PTSD and somatisation: a network analysis approach

Zammit, S., 2 Oct 2020, (Accepted/In press) In : Journal of Traumatic Stress.

Research output: Contribution to journalArticle (Academic Journal)

Effects of Early Life Adversity on Immune Function and Cognitive Performance: Results from the ALSPAC cohort

Holland, J., Khandaker, G., Dauvermann, M., Morris, D., Zammit, S. & Donohoe, G. J., 2 Jan 2020, In : Social Psychiatry and Psychiatric Epidemiology. 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence

Jones, H. J., Hammerton, G. L., McCloud, T., Hines, L. A., Wright, C. L., Gage, S. H., Holmans, P., Jones, P., Davey Smith, G., Linden, D. E., O'Donovan, M. C., Owen, M. J., Walters, J. T., Munafò, M. R., Heron, J. E. & Zammit, S., 9 Jun 2020, In : Psychological Medicine.

Research output: Contribution to journalArticle (Academic Journal)

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

Sallis, H. M., Croft, J., Havdahl, A., Jones, H. J., Dunn, E. C., Davey Smith, G., Zammit, S. & Munafò, M. R., 1 Apr 2020, In : Psychological Medicine. 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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69 Downloads (Pure)

Genetic studies of psychosis

Jones, H. J., Zammit, S. & Walters, J. T., 2020, Risk Factors for Psychosis: Paradigms, Mechanisms, and Prevention. Elsevier B.V., p. 183-209

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

GPs' views on identifying patients at-risk of psychosis: a qualitative study

Strelchuk, D., Wiles, N., Derrick, C., Zammit, S. & Turner, K., 13 Jul 2020, (Accepted/In press) In : British Journal of General Practice.

Research output: Contribution to journalArticle (Academic Journal)

High-Potency Cannabis, Mental Health and Substance Use in Adolescence: Results from a UK General Population Sample

Hines, L. A., Freeman, T. P., Gage, S. H., Zammit, S., Hickman, M., Cannon, M., Munafo, M. R., Macleod, J. A. A. & Heron, J. E., 27 May 2020, In : JAMA Psychiatry. 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Maternal smoking during pregnancy and offspring intellectual disability: sibling analysis in an intergenerational Danish cohort

Madley-Dowd, P., Kalkbrenner, A. E., Heuvelman, H. P., Heron, J. E., Zammit, S., Rai, D. & Schendel, D., 11 Sep 2020, (Accepted/In press) In : Psychological Medicine.

Research output: Contribution to journalArticle (Academic Journal)

Mental Health in UK Biobank – development, implementation and results from an online questionnaire completed by 157,366 participants: a reanalysis

Davis, K. A. S., Coleman, J. R. I., Zammit, S. & al., E., 6 Feb 2020, In : BJPsych Open. 6, 2, 8 p., e18.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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42 Downloads (Pure)

Omega-3 and Omega-6 Fatty acids and risk of psychotic outcomes in the ALSPAC birth cohort

Thompson, A., Jones, H. J., Heron, J. E., Hibblen, J., Sullivan, S. A. & Zammit, S., 24 Sep 2020, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
141 Downloads (Pure)
Open Access
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45 Downloads (Pure)
2019

Academic performance, externalizing disorders and depression: 26,000 adolescents followed into adulthood

Sörberg Wallin, A., Koupil, I., Gustafsson, J-E., Zammit, S., Allebeck, P. & Falkstedt, D., 12 Aug 2019, In : Social Psychiatry and Psychiatric Epidemiology. 54, 8, p. 977-986 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
161 Downloads (Pure)

ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort

Sabherwal, S., Föcking, M., English, J. A., Fitzsimons, S., Hryniewiecka, M., Wynne, K., Scaife, C., Healy, C., Cannon, M., Belton, O., Zammit, S., Cagney, G. & Cotter, D. R., 1 Jul 2019, In : Schizophrenia Research. 209, p. 141-147 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
27 Downloads (Pure)

Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits

Legge, S. E., Jones, H., Kendall, K., Pardiñas, A., Menzies, G., Bracher-Smith, M., Escott-Price, V., Rees, E., Davis, K. AS., Hotopf, M., Savage, J. E., Posthuma, D., Holmans, P., Kirov, G., Owen, M. J., O’Donovan, M. C., Zammit, S. & Walters, J. T., 25 Sep 2019, In : JAMA Psychiatry. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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18 Citations (Scopus)
18 Downloads (Pure)

Association of Genetic Risk for Rheumatoid Arthritis with Cognitive and Psychiatric Phenotypes Across Childhood and Adolescence

Jones, H., Hubbard, L., Mitchell, R., Jones, S. A., Williams, N. M., Zammit, S. & Hall, J., 21 Jun 2019, In : JAMA Network Open. 2, 6, 12 p., e196118.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
176 Downloads (Pure)

Association of Rare Copy Number Variants With Risk of Depression

Kendall, K. M., Rees, E., Bracher-Smith, M., Legge, S., Riglin, L., Zammit, S., O'Donovan, M. C., Owen, M. J., Jones, I., Kirov, G. & Walters, J. T. R., 18 Apr 2019, In : JAMA Psychiatry. 76, 8, p. 818-825 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Citations (Scopus)
299 Downloads (Pure)

Association of Trauma Type, Age of Exposure, and Frequency in Childhood and Adolescence with Psychotic Experiences in Early Adulthood

Croft, J., Heron, J. E., Teufel, C., Cannon, M., Wolke, D., Thompson, A., Houtepen, L. C. & Zammit, S., Jan 2019, In : JAMA Psychiatry. 76, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Citations (Scopus)
266 Downloads (Pure)

Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study

Richards, A., Horwood, J., Boden, J., Kennedy, M., Sellers, R., Riglin, L., Mistry, S., Jones, H., Smith, D. J., Zammit, S., Owen, M. J., O'Donovan, M. C. & Harold, G. T., 1 Feb 2019, In : British Journal of Psychiatry. 214, 2, p. 96-102 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
277 Downloads (Pure)

Complement Pathway Changes in Childhood are Associated with Incidence and Persistence of Psychotic Experiences in Adolescence: Evidence from the ALSPAC Birth Cohort

Föcking, M., Sabherwal, S., Cates, H. M., Scaife, C., Dicker, P., Hryniewiecka, M., Wynne, K., Rutten, B. P. F., Lewis, G. H., Cannon, M., Nestler, E. J., Heurich, M., Cagney, G., Zammit, S. & Cotter, D. R., 11 Jan 2019, In : Molecular Psychiatry. 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
161 Downloads (Pure)

Dysglycaemia, Inflammation and Psychosis: Findings from the UK ALSPAC Birth Cohort

Perry, B. I., Upthegrove, R., Thompson, A., Marwaha, S., Zammit, S., Singh, S. P. & Khandaker, G., 7 Mar 2019, In : Schizophrenia Bulletin. 45, 2, p. 330-338 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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15 Citations (Scopus)
173 Downloads (Pure)
142 Downloads (Pure)

Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood

Mistry, S., Escott-Price, V., Florio, A. D., Smith, D. J. & Zammit, S., 1 Mar 2019, In : Journal of Affective Disorders. 246, p. 633-639 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
88 Downloads (Pure)

Insulin Resistance and Obesity and their Association with Depression in Relatively Young People: Findings from a Large U.K. Birth Cohort

Perry, B. I., Khandaker, G., Marwaha, S., Thompson, A., Zammit, S., Singh, S. P. & Upthegrove, R., 8 Feb 2019, (Accepted/In press) In : Psychological Medicine. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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169 Downloads (Pure)

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children

Madrid-Gambin, F., Föcking, M., Sabherwal, S., Heurich, M., English, J., O'Gorman, A., Suvitaival, T., Ahonen, L., Cannon, M., Lewis, G., Mattila, I., Scaife, C., Madden, S., Hyotylainen, T., Oresic, M., Zammit, S., Cagney, G., Cotter, D. R. & Brennan, L., 1 Jul 2019, In : Biological Psychiatry. 86, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
221 Downloads (Pure)

Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood

Mistry, S., Escott-Price, V., Florio, A. D., Smith, D. J. & Zammit, S., 1 Dec 2019, In : Journal of Affective Disorders. 259, p. 112-120 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
10 Downloads (Pure)

Longitudinal association between inflammatory markers and specific symptoms of depression in a prospective birth cohort

Chu, A. L., Stochl, J., Lewis, G., Zammit, S., Jones, P. B. & Khandaker, G. M., 1 Feb 2019, In : Brain, Behavior, and Immunity. 76, p. 74-81 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
259 Downloads (Pure)

Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences

Roberts, S., Suderman, M., Zammit, S., Watkins, S. H., Hannon, E., Mill, J., Relton, C., Arseneault, L., Wong, C. C. Y. & Fisher, H. L., 4 Feb 2019, In : Translational Psychiatry. 9, 1, 12 p., 69.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
248 Downloads (Pure)

Longitudinal Population Subgroups of CRP and Risk of Depression in the ALSPAC birth cohort

Osimo, E. F., Stochl, J., Zammit, S., Lewis, G., Jones, P. B. & Khandaker, G. M., 31 Oct 2019, In : Comprehensive Psychiatry. 96, 7 p., 152143.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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110 Downloads (Pure)

Mendelian Randomization for Nutritional Psychiatry

Carnegie, R., Zheng, J., Sallis, H. M., Jones, H. J., Wade, K. H., Zammit, S., Evans, J., Zammit, S., Munafò, M. R. & Martin, R. M., 20 Nov 2019, In : Lancet Psychiatry. 7, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
20 Downloads (Pure)

MRI Indices of Cortical Development in Young People with Psychotic Experiences: Influence of Genetic Risk and Persistence of Symptoms

Fonville, L., Drakesmith, M., Zammit, S., Lewis, G. H., Jones, D. K. & David, A. S., 1 Jan 2019, In : Schizophrenia Bulletin. 45, 1, p. 169-179 11 p., sbx195.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
248 Downloads (Pure)

Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence: Findings From the ALSPAC Birth Cohort

Solmi, F., Zammit, S. & Kirkbride, J. B., 5 Jun 2019, In : Schizophrenia Bulletin. 11 p., sbz049.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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144 Downloads (Pure)

Pharmacogenomic variants and drug interactions identified through the genetic analysis of clozapine metabolism

Pardiñas, A. F., Nalmpanti, M., Pocklington, A., Legge, S., Medway, C., King, A., Jansen, J., Helthuis, M., Zammit, S., MacCabe, J. H., Owen, M. J., O'Donovan, M. C. & Walters, J. T., 1 Jun 2019, In : American Journal of Psychiatry. 176, 6, p. 477-486 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
172 Downloads (Pure)

Polygenic risk for schizophrenia, disordered eating behaviours and body mass index in adolescents

Solmi, F., Mascarell, M. C., Zammit, S., Kirkbride, J. B. & Lewis, G., 1 Jul 2019, In : British Journal of Psychiatry. 215, 1, p. 428-433 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
192 Downloads (Pure)
Open Access
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274 Downloads (Pure)

Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study

Vermeulen, J. M., Wootton, R. E., Treur, J. L., Sallis, H. M., Jones, H. J., Zammit, S., van den Brink, W., Goodwin, G. M., Haan, L. D. & Munafo, M. R., 17 Sep 2019, In : British Journal of Psychiatry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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57 Downloads (Pure)

Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype–Based Approach

Lancaster, T. M., Dimitriadis, S. L., Tansey, K. E., Perry, G., Ihssen, N., Jones, D. K., Singh, K. D., Holmans, P., Pocklington, A., Davey Smith, G., Zammit, S., Hall, J., O'Donovan, M. C., Owen, M. J. & Linden, D. E. J., 7 Mar 2019, In : Schizophrenia Bulletin. 45, 2, p. 405-414 10 p., sby037.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
185 Downloads (Pure)

The independent and cumulative effects of sibling and peer bullying in childhood on depression, anxiety, suicidal ideation, and self-harm in adulthood

Dantchev, S., Hickman, M., Heron, J., Zammit, S. & Wolke, D., 24 Sep 2019, In : Frontiers in Psychiatry. 10, 12 p., 651.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
154 Downloads (Pure)
2018

Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms

Davies, J., Sullivan, S. & Zammit, S., May 2018, In : Social Psychiatry and Psychiatric Epidemiology. 53, 5, p. 497–507 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
246 Downloads (Pure)

Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort

Khandaker, G. M., Zammit, S., Burgess, S., Lewis, G. & Jones, P. B., Mar 2018, In : Brain, Behavior, and Immunity. 69, p. 264-272 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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36 Citations (Scopus)
162 Downloads (Pure)

Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences

Jones, H., Gage, S., Heron, J., Hickman, M., Lewis, G., Munafo, M. & Zammit, S., 17 Jan 2018, In : JAMA Psychiatry. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
255 Downloads (Pure)

Association of copy number variation across the genome with neuropsychiatric traits in the general population

Guyatt, A. L., Stergiakouli, E., Martin, J., Walters, J., O'Donovan, M., Owen, M., Thapar, A., Kirov, G., Rodriguez, S., Rai, D., Zammit, S. & Gaunt, T. R., Jul 2018, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 177, 5, p. 489-502 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
220 Downloads (Pure)

Association of Residential Mobility Over the Life Course With Nonaffective Psychosis in 1.4 Million Young People in Sweden

Price, C., Dalman, C., Zammit, S. & Kirkbride, J., Nov 2018, In : JAMA Psychiatry. 75, 11, p. 1128-1136 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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15 Citations (Scopus)
244 Downloads (Pure)