Professor Stefan G E Roberts

PhD(Sheff.), BSc(Sheff.)

  • BS8 1TD

20062020

Research output per year

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Personal profile

Research interests

Group: Gene expression lab

Mechanisms of transcriptional regulation in mammalian cells

Transcription is at the heart of gene expression and is subject to strict control. The aberrant function of transcriptional regulators is associated with many cancers. How transcriptional regulators function is the focus of research in this laboratory. Our studies concern two major project areas;

1. Transcriptional regulation by the Wilms' tumour suppressor protein WT1

The transcriptional regulator WT1 is mutated in the paediatric cancer Wilms' tumour, and has also been linked with many other malignancies including Leukaemia, breast and lung cancer. The mechanism of action of WT1 is complex, having both transcriptional activation and repression activities. We are studying the transcription function of WT1 and how this changes in cancer. We are particularly interested in the WT1 cofactor, BASP1, which converts WT1 from a transcriptional activator to a repressor.

2. Regulation of the general transcription machinery

We are studying the mechanisms by which activator proteins stimulate transcription in mammalian cells. This involves both a biochemical approach and the use of in vivo transcription systems. A crucial function of transcriptional activators is the recruitment of the general transcription factor TFIIB to the promoter and is the subject of research in our laboratory.

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Projects

Research Output

  • 22 Article (Academic Journal)

Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice

Ahart, Z. C., Martin, L. E., Kemp, B. R., Banik, D. D., Roberts, S. G. E., Torregrossa, AM. & Medler, K. F., 23 Jan 2020, In : Obesity. 28 (2020), 2, p. 284-292 9 p.

Research output: Contribution to journalArticle (Academic Journal)

  • The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells

    Gao, Y., Banik, D., Muna, M., Roberts, S. & Medler, K. F., 5 Jun 2019, In : Life Science Alliance. 9 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 1 Citation (Scopus)
    124 Downloads (Pure)

    IDPpi: Protein-protein interaction analyses of human intrinsically disordered proteins

    Perovic, V., Sumonja, N., Marsh, L. A., Radovanovic, S., Vukicevic, M., Roberts, S. G. E. & Veljkovic, N., 12 Jul 2018, In : Scientific Reports. 8, 1, 10 p., 10563.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 3 Citations (Scopus)
    207 Downloads (Pure)

    Prizes

    Tenovus Medal (2003)

    Roberts, Stefan G E (Recipient), 2003

    Prize: Prizes, Medals, Awards and Grants

    Supervised Work

    Analysis of the function of BASP1 in endometrial cancer cells

    Author: Winter, T., 6 Nov 2018

    Supervisor: Roberts, S. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Investigating the Role of BASP1 Lipidation in WT1/BASP1 Mediated Gene Regulation

    Author: Dey, A., 7 May 2019

    Supervisor: Roberts, S. (Supervisor) & Malik, K. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Investigating the role of cholesterol in WT1/BASP1-mediated gene regulation

    Author: Fleming, A. F., 23 Jan 2020

    Supervisor: Roberts, S. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File