20042016

Research output per year

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Personal profile

Research interests

Each year, as many people die of fungal infections as of tuberculosis or malaria. Individuals at risk of contracting fungal infections include patients suffering from HIV/AIDS, undergoing cancer chemotherapy or organ transplantations and low-birthweight infants. Incidence rates of fungal infections are on the rise and so are the economic costs associated with life-threatening fungal infections due to the need for extended hospitalisations.

To mitigate the impact of fungal infections on human health and life, it is imperative to understand how fungi cause disease in humans. This will allow us identify suitable drug targets to effectively treat fungal infections. At Bristol's School of Cellular and Molecular Medicine, we aim to understand how heat shock protein Hsp90, a regulator of the cell’s protein homeostasis, regulates fungal virulence and evolution. We employ a two-pronged approach by combining research into the basic biology of Hsp90 in fungi with targeted quests for novel drug targets as currently available antifungal therapies are either ineffective or riddled by the emergence of antifungal drug resistance.

 

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Research Output

  • 12 Article (Academic Journal)
  • 1 Chapter in a book
  • 1 Other contribution

Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress

O'Meara, T., Veri, A., Polvi, E., Li, X., Valaei, S., Diezmann, S. & Cowen, L. E., 24 Jun 2016, In : PLoS Genetics. 12, 6, p. e1006142 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 187 Downloads (Pure)

    Functional divergence of Hsp90 genetic interactions in biofilm and planktonic cellular states

    Diezmann, S., Leach, M. D. & Cowen, L. E., 14 Sep 2015, In : PLoS ONE. 10, 9

    Research output: Contribution to journalArticle (Academic Journal)

  • The Enemy within: The Conversation

    Diezmann, S., 21 Aug 2015, The Conversation Trust (UK) Limited.

    Research output: Other contribution

  • Activities

    BBSRC (External organisation)

    Stephanie Diezmann (Advisor)

    2016 → …

    Activity: Membership typesMembership or peer review panel or committee

    Eukaryotic Cell (Journal)

    Stephanie Diezmann (Editor)

    20142016

    Activity: Publication peer-review and editorial work typesEditorial activity

    ASM Conference on Candida and Candidiasis

    Stephanie Diezmann (Participant)

    2014

    Activity: Participating in or organising an event typesParticipation in conference