Photo of Stephen C Harmer

Dr Stephen C Harmer

BSc(R'dg), PhD

  • BS8 1TD

20042020

Research output per year

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Research Output

  • 21 Article (Academic Journal)
  • 5 Review article (Academic Journal)
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Article (Academic Journal)
2020
Open Access
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40 Downloads (Pure)
2019

Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function

Cartwright, J. H., Aziz, Q., Harmer, S. C., Thayyil, S., Tinker, A. & Munroe, P. B., 19 Aug 2019, In : Human Molecular Genetics.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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111 Downloads (Pure)

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

Zhou, X., Bueno-Orovio, A., Schilling, R., Kirkby, C., Denning, C., Rajamohan, D., Burrage, K., Tinker, A., Rodriguez, B. & Harmer, S., 18 Mar 2019, In : Frontiers in Physiology. 10, 259, 14 p., 259.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
270 Downloads (Pure)
2018

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

Mosqueira, D., Mannhardt, I., Bhagwan, J. R., Lis-Slimak, K., Katili, P., Scott, E., Hassan, M., Prondzynski, M., Harmer, S. C., Tinker, A., Smith, J. G. W., Carrier, L., Williams, P. M., Gaffney, D., Eschenhagen, T., Hansen, A. & Denning, C., 14 Nov 2018, In : European Heart Journal. 39, 43, p. 3879-3892 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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162 Downloads (Pure)

Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths

Munroe, P. B., Addison, S., Abrams, D. J., Sebire, N. J., Cartwright, J., Donaldson, I., Cohen, M. M., Mein, C., Tinker, A., Harmer, S. C., Aziz, Q., Terry, A., Struebig, M., Warren, H. R., Vadgama, B., Fowler, D. J., Peebles, D., Taylor, A. M., Lally, P. J. & Thayyil, S., 11 Jan 2018, In : Circulation: Genomic and Precision Medicine. 11, 1, 10 p., e001817.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
2017

Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters

Miller, D. C., Harmer, S. C., Poliandri, A., Nobles, M., Edwards, E. C., Ware, J. S., Sharp, T. V., McKay, T. R., Dunkel, L., Lambiase, P. D. & Tinker, A., 1 Dec 2017, In : Stem Cell Research. 25, p. 233-244 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
245 Downloads (Pure)

Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells

Poliandri, A., Miller, D., Howard, S., Nobles, M., Ruiz-Babot, G., Harmer, S., Tinker, A., McKay, T., Guasti, L. & Dunkel, L., 15 May 2017, In : Molecular and Cellular Endocrinology. 447, p. 12-22 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
206 Downloads (Pure)

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking

Royal, A. A., Tinker, A. & Harmer, S. C., 11 Oct 2017, In : PLoS ONE. 12, 10, 22 p., e0186293.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
131 Downloads (Pure)
2016

GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway

Ishida, H., Saba, R., Kokkinopoulos, I., Hashimoto, M., Yamaguchi, O., Nowotschin, S., Shiraishi, M., Ruchaya, P., Miller, D., Harmer, S., Poliandri, A., Kogaki, S., Sakata, Y., Dunkel, L., Tinker, A., Hadjantonakis, A-K., Sawa, Y., Sasaki, H., Ozono, K., Suzuki, K. & 1 others, Yashiro, K., 26 Jul 2016, In : Cell Reports. 16, 4, p. 1026-1038 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
170 Downloads (Pure)

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Rodriguez, B., Carusi, A., Abi-Gerges, N., Ariga, R., Britton, O., Bub, G., Bueno-Orovio, A., Burton, R. A. B., Carapella, V., Cardone-Noott, L., Daniels, M. J., Davies, M. R., Dutta, S., Ghetti, A., Grau, V., Harmer, S., Kopljar, I., Lambiase, P., Lu, H. R., Lyon, A. & 12 others, Minchole, A., Muszkiewicz, A., Oster, J., Paci, M., Passini, E., Severi, S., Taggart, P., Tinker, A., Valentin, J-P., Varro, A., Wallman, M. & Zhou, X., 1 Sep 2016, In : EP-Europace. 18, 9, p. 1287-1298 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
186 Downloads (Pure)
2015

Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8

Nessa, A., Aziz, Q. H., Thomas, A. M., Harmer, S. C., Tinker, A. & Hussain, K., 15 Sep 2015, In : Human Molecular Genetics. 24, 18, p. 5142-53 12 p.

Research output: Contribution to journalArticle (Academic Journal)

2014

Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1

Harmer, S. C., Mohal, J. S., Royal, A. A., McKenna, W. J., Lambiase, P. D. & Tinker, A., 15 Aug 2014, In : Biochemical Journal. 462, 1, p. 133-42 10 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Downloads (Pure)
2013

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂

Telezhkin, V., Thomas, A. M., Harmer, S. C., Tinker, A. & Brown, D. A., Jul 2013, In : Pflügers Archiv: European Journal of Physiology. 465, 7, p. 945-53 9 p.

Research output: Contribution to journalArticle (Academic Journal)

2012

Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel

Harmer, S. C., Mohal, J. S., Kemp, D. & Tinker, A., 1 May 2012, In : Biochemical Journal. 443, 3, p. 635-42 8 p.

Research output: Contribution to journalArticle (Academic Journal)

2011

Characterization of a binding site for anionic phospholipids on KCNQ1

Thomas, A. M., Harmer, S. C., Khambra, T. & Tinker, A., 21 Jan 2011, In : Journal of Biological Chemistry. 286, 3, p. 2088-100 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations

Kapoor, RR., Flanagan, SE., James, CT., McKiernan, J., Thomas, AM., Harmer, SC., Hamilton-Shield, J. P., Tinker, A., Ellard, S. & Hussain, K., Oct 2011, In : Diabetologia. 54, 10, p. 2575-2583 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
35 Citations (Scopus)
231 Downloads (Pure)
2010

Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior

Mashanov, G. I., Nobles, M., Harmer, S. C., Molloy, J. E. & Tinker, A., 5 Feb 2010, In : Journal of Biological Chemistry. 285, 6, p. 3664-75 12 p.

Research output: Contribution to journalArticle (Academic Journal)

K+ channels in the heart: new insights and therapeutic implications

Tinker, A. & Harmer, S. C., May 2010, In : Expert Review of Clinical Pharmacology. 3, 3, p. 305-19 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Mechanisms of disease pathogenesis in long QT syndrome type 5

Harmer, S. C., Wilson, A. J., Aldridge, R. & Tinker, A., Feb 2010, In : AJP - Cell Physiology. 298, 2, p. C263-73

Research output: Contribution to journalArticle (Academic Journal)

2008

Evidence of a possible role for Lys-gamma3-MSH in the regulation of adipocyte function

Harmer, S. C., Pepper, D. J., Cooke, K., Bennett, H. P. J. & Bicknell, A. B., Jan 2008, In : Journal of Endocrinology. 196, 1, p. 149-58 10 p.

Research output: Contribution to journalArticle (Academic Journal)

2004

The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal

Harmer, S. C. & Bicknell, A. B., Nov 2004, In : Endocrine research. 30, 4, p. 629-35 7 p.

Research output: Contribution to journalArticle (Academic Journal)