Projects per year
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Research interests
Biology computes... from individual cells deciding how to differentiate during development, to social insects coordinating their actions when scavenging for food; the ability to perform complex computations and process information enables life.
The Biocompute Lab explores the molecular-scale mechanisms that individual cells and groups of cells use to make sense of their world. We apply tools and methods from the field of synthetic biology to create new living systems from the ground-up. By studying these artificial systems using novel techniques we are developing based on sequencing, microfluidics and computational modelling, we aim to better understand the rules governing how biological parts are best pieced together to perform useful computations. Understanding the computational architecture of cells opens new ways of reprogramming them to tackle problems spanning the sustainable production of materials to novel therapeutics. It also provides key insights into how biology controls the complex processes and structures sustaining life.
External positions
Postdoctoral Associate, Massachusetts Institute of Technology
Apr 2014 → Dec 2015
Marie Curie Fellow/Associate Scientist, DSM
Apr 2012 → Apr 2014
Keywords
- synthetic biology
- systems biology
- networks
- biotechnology
- sequencing
- computational biology
- translation
- transcription
- visualisation
- biodesign
- biometrology
- collective behaviours
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Engineered orthogonal ribosomes for programmable protein modification
1/01/22 → 31/12/22
Project: Research
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Engineered orthogonal ribosomes for programmable protein modification
1/01/22 → 31/12/22
Project: Research, Parent
Research output
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Improving the robustness of engineered bacteria to nutrient stress using programmed proteolysis
Szydlo, K., Ignatova, Z. & Gorochowski, T. E., 17 Feb 2022, In: ACS Synthetic Biology. 11, 3, p. 1049-1059 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Massively parallel characterization of engineered transcript isoforms using direct RNA sequencing
Tarnowski, M. J. & Gorochowski, T. E., 21 Jan 2022, In: Nature Communications. 13, 1, 14 p., 434.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile8 Downloads (Pure) -
Cheetah: a computational toolkit for cybergenetic control
Pedone, E., De Cesare, I., Zamora-Chimal, C. G., Haener, D., Postiglione, L., La Regina, A., Shannon, B., Savery, N. J., Grierson, C. S., Di Bernardo, M., Gorochowski, T. E. & Marucci, L., 27 Apr 2021, ACS Synthetic Biology, 10, 5, p. 979-989 11 p.Research output: Contribution to specialist publication › Article (Specialist Publication)
Open AccessFile3 Citations (Scopus)3 Downloads (Pure)