Dr Thomas E Gorochowski

PhD(Bristol), MRes(Bristol), MEng(Warw.)

  • BS8 1TQ

20102020

Research output per year

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Personal profile

Research interests

Biology computes... from individual cells deciding how to differentiate during development, to social insects coordinating their actions when scavenging for food; the ability to perform complex computations and process information enables life.

I head up the Biocompute Lab at the University of Bristol, which explores the molecular-scale mechanisms that individual cells and groups of cells use to make sense of their world. We apply tools and methods from the field of synthetic biology to create new living systems from the ground-up. By studying these artificial systems using novel techniques we are developing based on sequencing, microfluidics and computational modelling, we aim to better understand the rules governing how biological parts are best pieced together to perform useful computations. Understanding the computational architecture of cells opens new ways of reprogramming them to tackle problems spanning the sustainable production of materials to novel therapeutics. It also provides key insights into how biology controls the complex processes and structures sustaining life.

External positions

Postdoctoral Associate, MIT, Massachusetts Institute of Technology (MIT)

Apr 2014Dec 2015

Marie Curie Fellow/Associate Scientist, DSM

Apr 2012Apr 2014

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Projects

Research Output

An Engineering Theory of Evolution

Grierson, C. S., Castle, S. D. & Gorochowski, T. E., 26 Aug 2020, Preprints.org.

Research output: Contribution to specialist publicationArticle (Specialist Publication)

Cheetah: a computational toolkit for cybergenetic control

Gorochowski, T. E., Pedone, E., De Cesare, I., Zamora, C., Haener, D., Marucci, L., Postiglione, L., Shannon, B. M., Grierson, C. S., Savery, N. J. & Di Bernardo, M., 5 Aug 2020, bioRxiv.

Research output: Contribution to specialist publicationArticle (Specialist Publication)

Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads

Park, Y., Espah Borujeni, A., Gorochowski, T. E., Shin, J. & Voigt, C. A., 19 Aug 2020, In : Molecular Systems Biology. 16, 8, e9584.

Research output: Contribution to journalArticle (Academic Journal)

Open Access