Projects per year
Personal profile
Research interests
Biology computes... from individual cells deciding how to differentiate during development, to social insects coordinating their actions when scavenging for food; the ability to perform complex computations and process information enables life.
The Biocompute Lab explores the molecular-scale mechanisms that individual cells and groups of cells use to make sense of their world. We apply tools and methods from the field of synthetic biology to create new living systems from the ground-up. By studying these artificial systems using novel techniques we are developing based on sequencing, microfluidics and computational modelling, we aim to better understand the rules governing how biological parts are best pieced together to perform useful computations. Understanding the computational architecture of cells opens new ways of reprogramming them to tackle problems spanning the sustainable production of materials to novel therapeutics. It also provides key insights into how biology controls the complex processes and structures sustaining life.
External positions
Postdoctoral Associate, MIT, Massachusetts Institute of Technology (MIT)
Apr 2014 → Dec 2015Marie Curie Fellow/Associate Scientist, DSM
Apr 2012 → Apr 2014Fingerprint
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Network
Projects
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Next-generation agent-based modelling framework for multicellular design
1/06/18 → 31/03/21
Project: Research
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Research output
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Harnessing the central dogma for stringent multi-level control of gene expression
Greco, F. V., Pandi, A., Erb, T. J., Grierson, C. S. & Gorochowski, T. E., 18 Feb 2021, (Accepted/In press) In: Nature Communications.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Advances in engineering CRISPR-Cas9 as a molecular Swiss Army knife
Meaker, G. A., Hair, E. J. & Gorochowski, T. E., 24 Oct 2020, In: Synthetic Biology.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open Access -
Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads
Park, Y., Espah Borujeni, A., Gorochowski, T. E., Shin, J. & Voigt, C. A., 19 Aug 2020, In: Molecular Systems Biology. 16, 8, e9584.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile