Research output per year
Research output per year
Personal profile
Research interests
ABOUT THE SHARP LAB
We use a combination of protein engineering, DNA nanotechnology, synthetic biology, super-resolution light microscopy and high-resolution cryoEM to investigate immune system activation.
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Dive into the research topics where Thomas H Sharp is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Building a super-resolution fluorescence cryomicroscope
Last, M. G. F., Voortman, L. M. & Sharp, T. H., 13 Mar 2024, (E-pub ahead of print) In: Methods in Cell Biology. p. 205-222 18 p.Research output: Contribution to journal › Article (Academic Journal)
Open AccessFile28 Downloads (Pure) -
Design and Synthesis of DNA Origami Nanostructures to Control TNF Receptor Activation
Aba, G., Scheeren, F. A. & Sharp, T. H., 7 May 2024, Imaging Cell Signalling. Humana Press, p. 35-53 19 p. (Methods in Molecular Biology; vol. 2800).Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
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DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation
Abendstein, L., Noteborn, W. E. M., Veenman, L. S., Dijkstra, D. J., van de Bovenkamp, F. S., Trouw, L. A. & Sharp, T. H., 15 May 2024, In: Journal of the American Chemical Society. 146, 19, p. 13455-13466 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access5 Citations (Scopus)
Projects
- 2 Active
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Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Sharp, T. H. (Principal Investigator)
1/08/24 → 31/07/27
Project: Research, Parent
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Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Sharp, T. H. (Principal Investigator)
1/08/24 → 31/07/27
Project: Research