Research output per year
Research output per year
Personal profile
Research interests
ABOUT THE SHARP LAB
We use a combination of structural and synthetic biology to understand and control the human immune system.
Read more about our research at the Sharp lab website: https://sharplab.uk/
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Dive into the research topics where Thomas H Sharp is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Research output
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Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors
Li, Z., Joshi, B. S., Yin, H., Wijdeven, R. H., Koç, A., Zijlmans, D. W., Santos-Barriopedro, I., Mei, H., Wu, W., Shademan, M., Zawisza, F. M., Bos, E., Chopra, P., Tanenbaum, M. E., Sharp, T. H., Vermeulen, M., Raz, V. & Joo, C., 18 Dec 2025, In: Molecular Cell. 85, 24, p. 4633-4650.e11 30 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Dual-colour super-resolution cryoCLEM in mammalian cells using the fluorescent proteins rsTagRFP and rsEGFP2
Last, M. G. F., van Klaveren, M., Janssen, L., Jensen, N., Jansen, I., Jakobs, S., Voortman, L. M. & Sharp, T. H., 1 Dec 2025, In: Journal of Structural Biology. 217, 4, 10 p., 108267.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Inducing Cancer Cell Killing Using DNA Nanostructure-Mediated Superclustering of Death Receptors
Aba, G., Abudukelimu, S., de Winter, M., Collu, G., Bos, E., Hamers, S. M. W. R., Hawinkels, L. J. A. C., van Montfoort, N., Scheeren, F. A. & Sharp, T. H., 16 Apr 2025, In: Nano Letters. 25, 15, p. 6310-6317 8 p.Research output: Contribution to journal › Letter (Academic Journal) › peer-review
Open Access1 Citation (Scopus)
Projects
- 2 Active
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Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Sharp, T. H. (Principal Investigator)
1/08/24 → 31/07/27
Project: Research, Parent
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Targeting C-reactive protein using structure-guided drug design for therapeutic gain
Sharp, T. H. (Principal Investigator)
1/08/24 → 31/07/27
Project: Research