Dr Tim J Satchwell

MBiochem(Oxon.), PhD(Bristol)

  • BS8 1TD

20092020

Research output per year

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Research Output

  • 26 Article (Academic Journal)
  • 1 Letter (Academic Journal)
  • 1 Review article (Academic Journal)
2020

Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning

Moura, P. L., Dobbe, J. G. G., Streekstra, G. J., Rab, M. A. E., Veldthuis, M., Fermo, E., van Wijk, R., van Zwieten, R., Bianchi, P., Toye, A. M. & Satchwell, T., 19 May 2020, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle (Academic Journal)

2019

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Satchwell, T. J., Wright, K. E., Haydn-Smith, K. L., Sánchez-Román Terán, F., Moura, P. L., Hawksworth, J., Frayne, J., Toye, A. M. & Baum, J., 23 Aug 2019, In : Nature Communications. 10, 9 p., 3806 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
100 Downloads (Pure)

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis

Moura, P. L., Hawley, B. R., Dobbe, J. G. G., Streekstra, G. J., Rab, M. A. E., Bianchi, P., van Wijk, R., Toye, A. M. & Satchwell, T., 17 Oct 2019, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
150 Downloads (Pure)

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Moura, P. L., Lizarralde Iragorri, M. A., Francais, O., Le Pioufle, B., Dobbe, J. G. G., Streekstra, G. J., El Nemer, W., Toye, A. M. & Satchwell, T., 10 Sep 2019, In : Blood Advances. 3, 17, p. 2653-2663 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
110 Downloads (Pure)
2018

Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Hawksworth, J., Satchwell, T., Meinders, M., Daniels, D., Regan, F., Thornton, N., Wilson, M., Dobbe, J. G. G., Streekstra, G. J., Trakarnsanga, K., Heesom, K., Anstee, D., Frayne, J. & Toye, A., 26 Apr 2018, In : EMBO Molecular Medicine. 10, 5, 11 p., e8454.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
235 Downloads (Pure)

Non-muscle Myosin II Drives Vesicle Loss During Human Reticulocyte Maturation

Moura, P. L., Hawley, B., Anstee, D., Satchwell, T. & Toye, A., Dec 2018, In : Haematologica. 103, 12, p. 1997-2007 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
197 Downloads (Pure)

Quantitative measurement of red cell surface protein expression reveals new biomarkers for hereditary spherocytosis

Huisjes, R., Satchwell, T. J., Verhagen, L. P., Schiffelers, R. M., van Solinge, W. W., Toye, A. M. & van Wijk, R., 10 May 2018, In : International Journal of Laboratory Hematology. 4 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
2 Citations (Scopus)
152 Downloads (Pure)
2017

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

Trakarnsanga, K., Griffiths, R. E., Wilson, M. C., Blair, A., Satchwell, T. J., Meinders, M., Cogan, N., Kupzig, S., Kurita, R., Nakamura, Y., Toye, A. M., Anstee, D. J. & Frayne, J., 14 Mar 2017, In : Nature Communications. 8, 7 p., 14750.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
46 Citations (Scopus)
557 Downloads (Pure)

CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex

Mordue, K. E., Hawley, B. R., Satchwell, T. J. & Toye, A. M., 22 May 2017, In : Scientific Reports. 7, 14 p., 2246.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
235 Downloads (Pure)

Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion

Koch, M., Wright, K. E., Otto, O., Herbig, M., Salinas, N. D., Tolia, N. H., Satchwell, T., Guck, J., Brooks, N. J. & Baum, J., 18 Apr 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4225-4230 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
25 Citations (Scopus)
246 Downloads (Pure)
2016

A new junctional hierarchy

Satchwell, T. & Toye, A., 7 Jul 2016, In : Blood. 128, 1, p. 11-12 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
227 Downloads (Pure)

Erythrocyte invasion receptors for Plasmodium falciparum: new and old

Satchwell, T. J., Apr 2016, In : Transfusion Medicine. 26, 2, p. 77-88 12 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
18 Citations (Scopus)
305 Downloads (Pure)

Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton

Zuccala, E. S., Satchwell, T. J., Angrisano, F., Tan, Y. H., Wilson, M. C., Heesom, K. J. & Baum, J., 2 Feb 2016, In : Scientific Reports. 6, 16 p., 19766 .

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
24 Citations (Scopus)
225 Downloads (Pure)

Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts

Satchwell, T., Bell, A., Hawley, B., Pellegrin, S., Mordue, K. & Toye, A., 31 Aug 2016, In : Haematologica. 101, 9, p. 1018-1027 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
238 Downloads (Pure)
2015

The sorting of blood group active proteins during enucleation

Satchwell, T. J., Bell, A. J. & Toye, A. M., 1 Apr 2015, In : ISBT science series. 10, Suppl 1, p. 163-168 6 p.

Research output: Contribution to journalArticle (Academic Journal)

2014

Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte

Dasgupta, S., Auth, T., Gov, N. S., Satchwell, T. J., Hanssen, E., Zuccala, E. S., Riglar, D. T., Toye, A. M., Betz, T., Baum, J. & Gompper, G., 1 Jul 2014, In : Biophysical Journal. 107, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

The cytoskeletal binding domain of band 3 is required for multiprotein complex formation and retention during erythropoiesis

Satchwell, T. J., Hawley, B. R., Bell, A. J., Ribeiro, M. L. & Toye, A. M., 24 Oct 2014, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2013

Characteristic phenotypes associated with Congenital Dyserythropoietic Anemia (Type II) manifest at different stages of erythropoiesis

Satchwell, T. J., Pellegrin, S., Bianchi, P., Hawley, B. R., Gampel, A., Mordue, K. E., Budnik, A., Fermo, E., Barcellini, W., Stephens, D. J., Van den Akker, E. & Toye, A. M., 9 Aug 2013, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Protein Distribution during Human Erythroblast Enucleation In Vitro

Bell, A. J., Satchwell, T. J., Heesom, K. J., Hawley, B. R., Kupzig, S., Hazell, M., Mushens, R., Herman, A. & Toye, A. M., 2013, In : PLoS ONE. 8, 4, p. e60300

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
2012

Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal

Pellegrin, S., Heesom, K. J., Satchwell, T. J., Hawley, B. R., Daniels, G. L., van den Akker, E. & Toye, A. M., Jun 2012, In : PLoS ONE. 7, 6, p. 1-23 23 p., e38356.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Refined views of multi-protein complexes in the erythrocyte membrane

Mankelow, T. J., Satchwell, T. J. & Burton, N. M., 15 Jun 2012, In : Blood Cells, Molecules, and Diseases. 49, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
2011

Anion exchanger 1 in red blood cells and kidney: Band 3's in a pod

Wu, F., Satchwell, T. J. & Toye, A. M., Apr 2011, In : Biochemistry and Cell Biology. 89, 2, p. 106-14 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Critical band 3 multiprotein complex interactions establish early during human erythropoiesis

Satchwell, T. J., Bell, A. J., Pellegrin, S., Kupzig, S., Ridgwell, K., Daniels, G., Anstee, D. J., van den Akker, E. & Toye, A. M., Jul 2011, In : Blood. 118 , 1, p. 182 - 191 10 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)
2010

Anion exchanger 1 interacts with nephrin in podocytes

Wu, F., Saleem, M. A., Kampik, N. B., Satchwell, T. J., Williamson, R. C., Blattner, S. M., Ni, L., Toth, T., White, G., Young, M. T., Parker, M. D., Alper, S. L., Wagner, C. A. & Toye, A. M., Sep 2010, In : Journal of the American Society of Nephrology. 21 , 9, p. 1456 - 1467 12 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Band 3 multiprotein complexes in the red cell membrane; of mice and men

van den Akker, E., Satchwell, TJ., Williamson, RC. & Toye, AM., Jun 2010, In : Blood Cells, Molecules and Diseases. 45 (1), p. 1 - 8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (-) cells (Mutations Chatres 1 and 2)

van den Akker, E., Satchwell, T. J., Pellegrin, S., Flatt, J. F., Maigre, M., Daniels, G., Delaunay, J., Bruce, L. J. & Toye, A. M., Aug 2010, In : Haematologica. 95 , 8, p. 1278 - 1286 9 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
76 Citations (Scopus)
2009

Protein 4.2 : A complex linker

Satchwell, TJ., Shoemark, DK., Sessions, RB. & Toye, AM., May 2009, In : Blood Cells, Molecules, and Diseases. 42 (3), p. 201 - 210 10 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)