Tom R Gaunt

2024

Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank

Elmore, A., system, V., Hartley, A. E., Aparicio, H. J., Posner, D., Hemani, G., Tilling, K. M., Gaunt, T. R., Wilson, P., Casas, JP., Gaziano, J. M., Davey Smith, G., Paternoster, L., Cho, K. & Peloso, G. M., 1 Aug 2024, In: Stroke. 55, 8, p. 2045-2054 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data

Zheng, J., Lu, J., Qi, J., Yang, Q., Zhao, H., Liu, H., Chen, Z., Huang, L., Ye, Y., Xu, M., Xu, Y., Wang, T., Li, M., Zhao, Z., Zheng, R., Wang, S., Lin, H., Hu, C., Chui, C. S. L., Yeung, S. L. A., & 18 othersLuo, S., Dimopoulou, O., Dixon, P., Harrison, S., Liu, Y., Robinson, J., Yarmolinsky, J., Haycock, P., Yuan, J., Lewis, S., Yuan, Z., Gaunt, T. R., Smith, G. D., Ning, G., Martin, R. M., Cui, B., Wang, W. & Bi, Y., 20 Aug 2024, In: Cell Reports Medicine. 5, 8, p. 101688 1 p., 101688.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Triangulating evidence in health sciences with Annotated Semantic Queries

Liu, Y. & Gaunt, T., 1 Sept 2024, In: Bioinformatics. 40, 9, 13 p., btae519.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2023

Assessing the effects of hyperparameters on knowledge graph embedding quality

Lloyd, O., Gaunt, T. R. & Liu, Y., 6 May 2023, In: Journal of Big Data. 10, 1, 59.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

41 Downloads (Pure)

Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study

the PRACTICAL Consortium, 3 Jan 2023, In: PLoS Medicine. 20, 1, 23 p., e1003988.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

19 Citations (Scopus)

93 Downloads (Pure)

Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes

Schmidt, A. F., Joshi, R., Gordillo-Marañón, M., Drenos, F., Gaunt, T. R. & Lawlor, D. A., 20 Jan 2023, In: Communications Medicine. 3, 1, 9.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

6 Citations (Scopus)

49 Downloads (Pure)

Causal relationships between anthropometric traits, bone mineral density, osteoarthritis and spinal stenosis: A Mendelian randomisation investigation

Sobczyk-Barad, M. K., Faber, B. G., Southam, L., Frysz, M. R., Hartley, A. E., Zeggini, E., Tang, H., Gaunt, T. R. & al, E., 30 Dec 2023, In: Osteoarthritis and Cartilage. 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Causal relationships between anthropometric traits, bone mineral density, osteoarthritis and spinal stenosis: a Mendelian randomization investigation

Sobczyk, M. K., Faber, B. G., Southam, L., Frysz, M., Hartley, A., Zeggini, E., Tang, H. & Gaunt, T. R., 15 Aug 2023

Research output: Other contribution

Design and quality control of large-scale two-sample Mendelian randomization studies

Haycock, P. C., Borges, M. C., Burrows, K., Harrison, S., Gaunt, T. R., Hemani, G., Zheng, J., Davey Smith, G., Relton, C. L. & Martin, R. M., 12 Apr 2023, In: International Journal of Epidemiology. 52, 5, p. 1498-1521 24 p., dyad018.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

184 Downloads (Pure)

Drug target Mendelian Randomization: Are we really instrumenting drug use? Reply to Anderson EL, Williams DM [letter]

Zheng, J., Gaunt, T. R., Xu, M., Davey Smith, G. & Bi, Y., 10 Mar 2023, In: Diabetologia. 66, p. 1159-1161 3 p.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study

Zheng, J., Xu, M., Yang, Q., Hu, C., Walker, V., Lu, J., Wang, J., Liu, R., Xu, Y., Wang, T., Zhao, Z., Yuan, J., Burgess, S., Au Yeung, S. L., Luo, S., Anderson, E. L., Holmes, M. V., Smith, G. D., Ning, G., Wang, W., & 2 othersGaunt, T. R. & Bi, Y., 19 Sept 2023, In: EBioMedicine. 96, p. 104803

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases

Sobczyk-Barad, M. K., Zheng, J., Davey Smith, G. & Gaunt, T. R., 26 Sept 2023, In: BMJ Open. 13, 9, 15 p., e072087.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

29 Downloads (Pure)

The association between genetically elevated polyunsaturated fatty acids and risk of cancer

Haycock, P. C., Borges, M. C., Burrows, K., Gaunt, T. R., Hemani, G., Williams, A. C., Davey Smith, G., Relton, C. L. & Martin, R. M., 20 Apr 2023, (E-pub ahead of print) In: EBioMedicine. 91, 13 p., 104510.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Downloads (Pure)

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

UCLEB Consortium, 4 Sept 2023, In: BMC Medicine. 21, 1, p. 340 340.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Using language models and ontology topology to perform semantic mapping of traits between biomedical datasets

Liu, Y., Elsworth, B. & Gaunt, T. R., 3 Apr 2023, In: Bioinformatics. 39, 4, 7 p., btad169.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

35 Downloads (Pure)

2022

Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers

Fang, S., Holmes, M. V., Gaunt, T. R., Davey Smith, G. & Richardson, T. G., 11 Oct 2022, In: eLife. 16 p., e73951.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

53 Downloads (Pure)

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

Fang, S., Hemani, G., Richardson, T. G., Gaunt, T. R. & Davey Smith, G., 6 Aug 2022, In: Human Molecular Genetics.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

117 Downloads (Pure)

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study

Zheng, J., Xu, M., Walker, V., Yuan, J., Korologou-Linden, R., Robinson, J., Huang, P., Burgess, S., Au Yeung, S. L., Luo, S., Holmes, M. V., Davey Smith, G., Ning, G., Wang, W., Gaunt, T. R. & Bi, Y., 1 Oct 2022, In: Diabetologia. 65, 10, p. 1664-1675 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

39 Citations (Scopus)

86 Downloads (Pure)

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation

Longchamps, R. J., Yang, S. Y., Castellani, C. A., Shi, W., Lane, J., Grove, M. L., Bartz, T. M., Sarnowski, C., Liu, C., Burrows, K., Guyatt, A. L., Gaunt, T. R., Kacprowski, T., Yang, J., De Jager, P. L., Yu, L., Bergman, A., Xia, R., Fornage, M., Feitosa, M. F., & 32 othersWojczynski, M. K., Kraja, A. T., Province, M. A., Amin, N., Rivadeneira, F., Tiemeier, H., Uitterlinden, A. G., Broer, L., Van Meurs, J. B. J., Van Duijn, C. M., Raffield, L. M., Lange, L., Rich, S. S., Lemaitre, R. N., Goodarzi, M. O., Sitlani, C. M., Mak, A. C. Y., Bennett, D. A., Rodriguez, S., Murabito, J. M., Lunetta, K. L., Sotoodehnia, N., Atzmon, G., Ye, K., Barzilai, N., Brody, J. A., Psaty, B. M., Taylor, K. D., Rotter, J. I., Boerwinkle, E., Pankratz, N. & Arking, D. E., Jan 2022, In: Human Genetics. 141, 1, p. 127-146 20 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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25 Citations (Scopus)

52 Downloads (Pure)

Global Biobank Meta-analysis Initiative: powering genetic discovery across human disease

Zhou, W., Kanai, M., Rasheed, H., Tsuo, K., Davey Smith, G., Zhao, H., Gaunt, T. R., Zheng, J., Willer, C. J., Daly, M. J. & Neale, B. M., 12 Oct 2022, (E-pub ahead of print) In: Cell Genomics. 12, 10, 20 p., 100192.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

112 Citations (Scopus)

Integrating Mendelian randomization and literature-mined evidence for breast cancer risk factors

Vabistsevits, M., Robinson, T., Elsworth, B., Liu, Y. & Gaunt, T., 22 Jul 2022.

Research output: Working paper › Preprint

Linking physical activity to breast cancer: text mining results and a protocol for systematically reviewing three potential mechanistic pathways

Lynch, B., Milne, R. L., English, D. R., Brown, K. A., Drummond, A. E., Swain, C. T. V., van Roekel, E. H., Moore, M. M., Gaunt, T. R., Martin, R. M. & Lewis, S. J., Jan 2022, In: Cancer Epidemiology, Biomarkers and Prevention. 31, 1, p. 11-15 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

35 Downloads (Pure)

Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk

Drummond, A. E., Swain, C. T. V., Milne, R. L., English, D. R., Brown, K. A., Skinner, T. L., Lay, J., van Roekel, E. H., Moore, M. M., Gaunt, T. R., Martin, R. M., Lewis, S. J. & Lynch, B. M., 5 Dec 2022, In: Cancer Epidemiology, Biomarkers and Prevention. 31, 12, p. 2116-2125 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

6 Citations (Scopus)

24 Downloads (Pure)

Linking physical activity to breast cancer via sex hormones, part 1: The effect of physical activity on sex steroid hormones

swain, C., Gaunt, T. R., Martin, R. M., Lewis, S. J. & Lynch, B., 1 Jan 2022, In: Cancer Epidemiology, Biomarkers and Prevention. 31, 1, p. 16-27 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

36 Downloads (Pure)

Linking Physical Activity to Breast Cancer via Sex Steroid Hormones, Part 2: The Effect of Sex Steroid Hormones on Breast Cancer Risk

Drummond, A. E., Swain, C. T. V., Brown, K. A., Dixon-Suen, S. C., Boing, L., van Roekel, E. H., Moore, M. M., Gaunt, T. R., Milne, R. L., English, D. R., Martin, R. M., Lewis, S. J. & Lynch, B., 1 Jan 2022, In: Cancer Epidemiology, Biomarkers and Prevention. 31, 1, p. 28-37 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

63 Downloads (Pure)

Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity

Zheng, J., Zhang, Y., Zhao, H., Liu, Y., Baird, D., Karim, M. A., Ghoussaini, M., Schwartzentruber, J., Dunham, I., Elsworth, B., Roberts, K., Compton, H., Miller-Molloy, F., Liu, X., Wang, L., Zhang, H., Smith, G. D. & Gaunt, T. R., 27 Jun 2022, In: EBioMedicine. 81, 13 p., 104112.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

229 Downloads (Pure)

Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond

Walker, V. M., Zheng, J., Gaunt, T. R. & Smith, G. D., 10 Aug 2022, In: Annual review of biomedical data science. 5, p. 1-17 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

File

8 Citations (Scopus)

73 Downloads (Pure)

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

Zhao, H., Rasheed, H., Cho, Y., Liu, Y., Hemani, G., Davey Smith, G., Gaunt, T. R. & Zheng, J., 9 Nov 2022, In: Cell Genomics. 2, 11, 100195.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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19 Citations (Scopus)

89 Downloads (Pure)

Reply to Janssen et al. Comment on “Sobczyk, M.K.; Gaunt, T.R. The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study. Nutrients 2022, 14, 233

Sobczyk-Barad, M. K. & Gaunt, T. R., 7 Mar 2022, In: Nutrients. 14, 5, p. 1-2 2 p., 1113.

Research output: Contribution to journal › Comment/debate (Academic Journal)

Open Access

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3 Citations (Scopus)

49 Downloads (Pure)

Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes

Walker, V. M., Vujkovic, M., Carter, A. R., Davies, N. M., Udler, M., Levin, M., Davey Smith, G., Voight, B. F., Gaunt, T. R. & Damrauer, S. M., 7 Feb 2022, In: Diabetologia. 65, 5, p. 790-799 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

53 Downloads (Pure)

The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study

Sobczyk-Barad, M. K. & Gaunt, T. R., 6 Jan 2022, In: Nutrients. 14, 2, p. 1-17 17 p., 233.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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25 Citations (Scopus)

207 Downloads (Pure)

The EWAS Catalog: a database of epigenome-wide association studies

Battram, T., Yousefi, P., Crawford, G., Prince, C., Sheikhali Babaei, M., Sharp, G., Hatcher, C., Vega-Salas, M. J., Khodabakhsh, S., Whitehurst, O., Langdon, R., Mahoney, L., Elliott, H. R., Mancano, G., Lee, M. A., Watkins, S. H., Lay, A. C., Hemani, G., Gaunt, T. R., Relton, C. L., & 2 othersStaley, J. R. & Suderman, M., 31 May 2022, In: Wellcome Open Research. 7, p. 41

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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75 Citations (Scopus)

179 Downloads (Pure)

The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study

Borges, M. C., Haycock, P. C., Zheng, J., Hemani, G., Howe, L. J. M. S., Schmidt, A. F., Staley, J. R., Lumbers, R. T., Henry, A., Lemaitre, R. N., Gaunt, T. R., Holmes, M. V., Davey Smith, G., Hingorani, A. & Lawlor, D. A., 1 Dec 2022, In: Human Molecular Genetics. 31, 23, p. 4034-4054 21 p., ddac153.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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4 Citations (Scopus)

45 Downloads (Pure)

2021

An Informatics Consult approach for generating clinical evidence for treatment decisions

Lai, A., Hoong Chang, W., Parisinos, C. A., Katsoulis, M., Blackburn, R., Shah, A., Nguyen, V., Denaxas, S., Davey Smith, G., Gaunt, T. R., Nirantharakumar, K., Cox, M. P., Forde, D., Asselbergs, F. W., Harris, S., Richardson, S., Sofat, R., Dobson, R. R. H., Hingorani, A. D., Patel, R. S., & 10 othersSterne, J. A. C., Banerjee, A., Denniston, A. K. O., Denniston, A. K. O., Ball, S., Sebire, N., Shah, N., Foster, G., Williams, B. & Hemingway, H., 12 Oct 2021, (E-pub ahead of print) In: BMC Medical Informatics and Decision Making. 21, 281.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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53 Downloads (Pure)

Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants

Millard, L. A. C., Tilling, K., Gaunt, T. R., Carslake, D. & Lawlor, D. A., Sept 2021, In: PLoS Medicine. 18, 9, e1003757.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

53 Downloads (Pure)

Cholesteryl Ester Transfer Protein (CETP) as a Drug Target for Cardiovascular Disease

Schmidt, A. F., Lawlor, D. A. & Gaunt, T. R., 24 Sept 2021, In: Nature Communications. 12, 1, 10 p., 5640.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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56 Citations (Scopus)

63 Downloads (Pure)

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Boer, C. G., Hatzikotoulas, K., Southam, L., Stefansdottir, L., Zhang, Y., Coutinho de Almeida, R., wu, T. T., Zhang, J., Hartley, A. E., Teder-Laving, M., Skogholt, A. H., Terao, C., Zengini, E., Alexiadis, G., Barysenka, A., Bjornsdottir, G., Gabrielsen, M., Gilly, A., Ingvarsson, T., Johnsen, M. B., & 42 othersJonsson, H., Kloppenburg, M., Luetge, A., Lund, S. H., Mägi, R., Mangino, M., Nelissen, R., Shivakumar, M., Steinberg, J., Takuwa, H., Thomas, L., Tuerlings, M., Babis, G. C., Pui Yin Cheung, J., Kang, J. H., Kraft, P., Lietman, S. A., Samartzis, D., Slagboom, E., Stefansson, K., Thorsteinsdottir, U., Tobias, J. H., Uitterlinden, A. G., Winsvold, B. S., Zwart, J-A., Davey Smith, G., Sham, P. C., Thorleifsson, G., Gaunt, T. R., Morris, A., Valdes, A. M., Tsezou, A., S.E. Cheah, K., Ikegawa, S., Hveem, K., Esko, T., Wilkinson, J. M., Meulenbelt, I., Ta Michael Lee, M., van Meurs, J. B. J., Styrkarsdottir, U. & Zeggini, E., 2 Sept 2021, In: Cell. 184, 18, p. 4784-4818.e17 53 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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190 Citations (Scopus)

75 Downloads (Pure)

Design and quality control of large-scale two-sample Mendelian randomisation studies

Haycock, PC., Borges, MC., Burrows, K., Lemaitre, RN., Harrison, S., Burgess, S., Chang, X., Westra, J., Khankari, NK., Tsilidis, K., Gaunt, T., Hemani, G., Zheng, J. & PanC4, Aug 2021, (In preparation)

Research output: Other contribution

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Mulder, R. H., Gaunt, T. R., Relton, C. L., Suderman, M. & al., E., 25 Mar 2021, In: Genome Biology. 30, 1, p. 119-134 16 p., ddaa280.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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59 Citations (Scopus)

99 Downloads (Pure)

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

Longchamps, R., Yang, S., Castellani, C., Shi, W., Lane, J., Grove, M., Bartz, T., Sarnowski, C., Burrows, K., Guyatt, A., Gaunt, T., Kacprowski, T., Yang, J., De, J. P. & Group, CHARGE. A. A. L., Jan 2021

Research output: Other contribution

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

et al., Min, J. L., Hemani, G., Hannon, E., dekkers, K., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M. J., Bretherick, A. D., Richardson, T. G., Klughammer, J., Lochkova, V., Sharp, G. C., Al Khleifat, A., Shatunov, A., Lacoangeli, A., Mcardle, W. L., & 16 othersHo, K. M., Kumar, A., Soderhall, C., Soriano-Tárraga, C., Giralt-Steinhauer, E., Kazmi, N., Mason, D., McRae, A. F., Corcoran, D. L., Elliott, H. R., Ring, S. M., Lawlor, D. A., Sørensen, T. I. A., Davey Smith, G., Gaunt, T. R. & Relton, C. L., 6 Sept 2021, (E-pub ahead of print) In: Nature Genetics. 53, 9, p. 1311-1321 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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187 Citations (Scopus)

27 Downloads (Pure)

MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes

Sobczyk-Barad, M. K., Gaunt, T. R. & Paternoster, L., 9 Apr 2021, In: Bioinformatics. 37, 1, p. 1-8 8 p., btaa1096.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

111 Downloads (Pure)

Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020

Tobias, J. H., Duncan, E. L., Kague, E., Hammond, C. L., Gregson, C. L., Bassett, D., Williams, G. R., Min, J. L., Gaunt, T. R., Karasik, D., Ohlsson, C., Rivadeneira, F., Edwards, J. R., Hannan, F. M., Kemp, J. P., Gilbert, S. J., Alonso, N., Hassan, N., Compston, J. E. & Ralston, S. H., 15 Feb 2021, In: Frontiers in Endocrinology. 11, 630875.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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7 Citations (Scopus)

73 Downloads (Pure)

Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study

Luo, S., Clarke, SLN., Ramanan, AV., Thompson, SD., Langefeld, CD., Marion, MC., Grom, AA., Schooling, CM., Gaunt, TR., Yeung, SLA. & Zheng, J., Apr 2021, In: Arthritis and Rheumatology. 73, 4, p. 693-701 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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9 Citations (Scopus)

96 Downloads (Pure)

The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian randomization analyses

Rasheed, H., Zheng, J., Rees, J., Sanderson, E., Thomas, L., Richardson, T. G., Fang, S., Bekkevold, O-J., Stovner, E. B., Gabrielsen, M. E., Skogholt, A. H., Romundstad, S., Brumpton, B., Hallan, S., Willer, C., Burgess, S., Hveem, K., Davey Smith, G., Gaunt, T. R. & Asvold, B. O., 10 Nov 2021, In: International Journal of Epidemiology. 50, 5, p. 1569-1579 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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16 Citations (Scopus)

113 Downloads (Pure)

The variant call format provides efficient and robust storage of GWAS summary statistics

Lyon, M. S., Andrews, S., Elsworth, B. L., Gaunt, T. R., Hemani, G. & Marcora, E., 13 Jan 2021, In: Genome Biology. 22, 1, 10 p., 32.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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85 Citations (Scopus)

218 Downloads (Pure)

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease

Zheng, J., Zhang, Y., Rasheed, H., Walker, V. M., Sugawara, Y., Li, J., Leng, Y., Elsworth, B. L., Wootton, R. E., Fang, S., Yang, Q., Burgess, S., Haycock, P. C., Borges, M. C., Cho, Y., Carnegie, R., Howell, A. E., Robinson, J. W., Thomas, L., Brumpton, B. M., & 23 othersHveem, K., Hallan, S., Franceschini, N., Morris, A., Köttgen, A., Pattaro, C., Wuttke, M., Yamamoto, M., Kashihara, N., Akiyama, M., Kanai, M., Matsuda, K., Kamatani, Y., Okada, Y., Walters, R., Millwood, I., Chen, Z., Davey Smith, G., Barbour, S., Yu, C., Åsvold, B. O., Zhang, H. & Gaunt, T. R., 1 Dec 2021, In: International Journal of Epidemiology. 50, 6, p. 1995-2010 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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39 Citations (Scopus)

133 Downloads (Pure)

Triangulating molecular evidence to prioritize candidate causal genes at established atopic dermatitis loci

Sobczyk-Barad, M. K., Richardson, T. G., Zuber, V., Min, J. L., Gaunt, T. R. & Paternoster, L., Nov 2021, In: Journal of Investigative Dermatology. 141, 11, p. 2620-2629 10 p., S0022-202X(21)01160-XDOI.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

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Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

Gordillo-Marañón, M., Gaunt, T. R. & Lawlor, D. A., 21 Oct 2021, In: Nature Communications. 12, 1, 6120.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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10 Citations (Scopus)

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2020

ANNALS EXPRESS: Establishing reference intervals for triglyceride containing lipoprotein sub-fraction metabolites measured using Nuclear Magnetic Resonance Spectroscopy in a UK population

Joshi, R., Lawlor, D. A., Wannamethee, S. G., Engmann, J., Gaunt, T. R., Price, J. F., Papacosta, O., Shah, T., Tillin, T., Whincup, P., Chaturvedi, N., Kivimaki, M. J., Kuh, D., Kumari, M., Hughes, A. D., Casas, J-P., Humphries, S. E., Hingorani, A. D. & Schmidt, A. F., 16 Sept 2020, In: Annals of Clinical Biochemistry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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2 Citations (Scopus)

72 Downloads (Pure)

Professor Tom R Gaunt

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