20002020

Research output per year

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Research Output

2020

Associations Between High Blood Pressure and DNA Methylation

Kazmi, N., Elliott, H. R., Burrows, K., Tillin, T., Hughes, A. D., Chaturvedi, N., Gaunt, T. R. & Relton, C. L., 30 Jan 2020, In : PLoS ONE. 15, 1, 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
65 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
71 Downloads (Pure)
Open Access
File
7 Downloads (Pure)
Open Access
File
44 Downloads (Pure)

CScape-somatic: distinguishing driver and passenger point mutations in the cancer genome

Rogers, M. F., Gaunt, T. R. & Campbell, C., 13 Apr 2020, In : Bioinformatics. btaa242.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Downloads (Pure)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

Cho, Y., Haycock, P. C., Sanderson, E., Gaunt, T. R., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 21 Feb 2020, In : Nature Communications. 11, 13 p., 1010 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
51 Downloads (Pure)

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage

Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators, Mar 2020, In : Journal of Neurology, Neurosurgery, and Psychiatry. 91, 3, p. 305-313 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
38 Downloads (Pure)

Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage

Hostettler, I. C., Morton, M. J., Ambler, G., Kazmi, N., Gaunt, T. R., Wilson, D., Shakeshaft, C., Jäger, H. R., Cohen, H., Yousry, T., Salman, R. A-S., Lip, G. Y. H., Brown, M., Muir, K. W., Houlden, H., Bulters, D. O., Galea, I. & Werring, D. J., 10 Jan 2020, In : Journal of Neurology, Neurosurgery, and Psychiatry. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
56 Downloads (Pure)

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

Langdon, R. J., Richmond, R. C., Elliott, H. R., Dudding, T., Kazmi, N., Penfold, C., Ingarfield, K., Ho, K. M., Bretherick, A. D., Haley, C. S., Zeng, Y., Walker, R., Pawlita, M., Waterboer, T., Gaunt, T. R., Davey Smith, G., Suderman, M. J., Thomas, S. J., Ness, A. R. & Relton, C. L., 29 Jun 2020, In : Clinical Epigenetics. 12, 19 p., 95 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Downloads (Pure)

MELODI Presto: A fast and agile tool to explore semantic triples derived from biomedical literature

Elsworth, B. L. & Gaunt, T. R., 5 Aug 2020, (Accepted/In press) In : Bioinformatics.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Downloads (Pure)
Open Access
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44 Downloads (Pure)

Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults

Joshi, R., Wannamethee, S. G., Engmann, J., Gaunt, T., Lawlor, D. A., Price, J., Papacosta, O., Shah, T., Tillin, T., Chaturvedi, N., Kivimaki, M., Kuh, D., Kumari, M., Hughes, A. D., Casas, J. P., Humphries, S., Hingorani, A. D. & Schmidt, A. F., 29 Jan 2020, In : European Journal of Preventive Cardiology. p. 2047487319899621

Research output: Contribution to journalArticle (Academic Journal)

2019

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

Guyatt, A. L., Brennan, R. R., Burrows, K., Guthrie, P. A. I., Ascione, R., Ring, S. M., Gaunt, T. R., Pyle, A., Cordell, H. J., Lawlor, D. A., Chinnery, P. F., Hudson, G. & Rodriguez, S., 31 Jan 2019, In : Human Genomics. 13, 17 p., 6.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
194 Downloads (Pure)

Appraising the causal relevance of DNA methylation for risk of lung cancer

Battram, T., Richmond, R., Baglietto, L., Haycock, P., Perduca, V., Bojensen, S., Gaunt, T., Hemani, G., Guida, F., Carreras-Torres, R., Hung, R. J., Amos, C. I., Freeman, J., Sandanger, T. M., Nøst, T., Nordestgaard, B. G., Teschendorff, A. E., Polidoro, S., Vineis, P., Severi, G. & 7 others, Hodge, A., Giles, G. G., Grankvist, K., Johansson, M., Johansson, M., Davey Smith, G. & Relton, C., 24 Sep 2019, In : International Journal of Epidemiology. 12 p., dyz190.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
128 Downloads (Pure)

Availability of public databases for triangulation of findings

Lyon, M., Munafo, M., Gaunt, T. & Davey Smith, G., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 15766-15767 2 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
1 Citation (Scopus)
53 Downloads (Pure)

Estimating the Frequency of Single Point Driver Mutations across Common Solid Tumours

Darbyshire, M., du Toit, Z., Rogers, M. F., Gaunt, T. R. & Campbell, C., 17 Sep 2019, In : Scientific Reports. 9, 11 p., 13452 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
154 Downloads (Pure)

Genetic determinants of circulating haptoglobin concentration

Kazmi, N., Koda, Y., Ndiaye, N. C., Visvikis-Siest, S., Morton, M. J., Gaunt, T. R. & Galea, I., 1 Jul 2019, In : Clinica Chimica Acta. 494, p. 138-142 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
214 Downloads (Pure)

Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis

Hatzikotoulas, K., Tachmazidou, I., Southam, L., Esparza-Gordillo, J., Haberland, V., Zheng, J., Johnson, T., Koprulu, M., Zengini, E., Steinberg, J., Wilkinson, J., Bhatnagar, S., Hoffman, J. D., Buchan, N., Suveges, D., Yerges-Armstrong, L. M., Davey Smith, G., Gaunt, T., Scott, R., McCarthy, L. C. & 1 others, Zeggini, E., Apr 2019.

Research output: Contribution to conferenceConference Abstract

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns: Findings From the Pregnancy and Childhood Epigenetics Consortium

Kazmi, N., Sharp, G. C., Reese, S. E., Vehmeijer, F. O., Lahti, J., Page, C. M., Zhang, W., Rifas-Shiman, S. L., Rezwan, F. I., Simpkin, A. J., Burrows, K., Richardson, T. G., Santos Ferreira, D. L., Fraser, A., Harmon, Q. E., Zhao, S., Jaddoe, V. W. V., Czamara, D., Binder, E. B., Magnus, M. C. & 23 others, Håberg, S. E., Nystad, W., Nohr, E. A., Starling, A. P., Kechris, K. J., Yang, I. V., DeMeo, D. L., Litonjua, A. A., Baccarelli, A., Oken, E., Holloway, J. W., Karmaus, W., Arshad, S. H., Dabelea, D., Sørensen, T. I. A., Laivuori, H., Raikkonen, K., Felix, J. F., London, S. J., Hivert, M. F., Gaunt, T. R., Lawlor, D. A. & Relton, C. L., 1 Aug 2019, In : Hypertension. 74, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
145 Downloads (Pure)

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

arcOGEN Consortium, Feb 2019, In : Nature Genetics. 51, 2, p. 230-236 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
37 Citations (Scopus)
139 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
154 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
200 Downloads (Pure)

Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study

De Silva, M., Borges, C., Hingorani, A., Engmann, J., Shah, T., Zhang, X., Luan, J., Langenberg, C., Wong, A., Kuh, D., Chambers, J. C., Zhang, W., Jarvelin, M-R., Sebert, S., Auvinen, J., UCLEB Consortium, Gaunt, T. & Lawlor, D., 1 Aug 2019, In : Diabetes. 68, 8, p. 1681-1691 11 p., db181048.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
387 Downloads (Pure)

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Haworth, S., Shapland, C. Y., Hayward, C., Prins, B. P., Felix, J. F., Medina-Gomez, C., Rivadeneira, F., Wang, C., Ahluwalia, T. S., Vrijheid, M., Guxens, M., Sunyer, J., Tachmazidou, I., Walter, K., Iotchkova, V., Jackson, A., Cleal, L., Huffmann, J., Min, J. L., Sass, L. & 7 others, Timmers, P. R. H. J., UK10K Consortium, Davey Smith, G., Cole, T. J., Timpson, N., Zeggini, E. & St Pourcain, B., 21 Jan 2019, In : Nature Communications. 10, 16 p., 357.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
122 Downloads (Pure)

MR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways

Cho, Y., Haycock, P., Gaunt, T., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 2019, (Submitted) In : Nature Communications.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
212 Downloads (Pure)
Open Access
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12 Citations (Scopus)
225 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
162 Downloads (Pure)

Vectology – exploring biomedical variable relationships using sentence embedding and vectors

Elsworth, B. L., Liu, Y. & Gaunt, T. R., 15 Nov 2019, Turing seminar on recommender systems.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2018

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Slieker, R., Relton, C., Gaunt, T., Slagboom, P. E. & Heijmans, B. T., 30 May 2018, In : Epigenetics and Chromatin. 11, 1, 11 p., 25.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
31 Citations (Scopus)
237 Downloads (Pure)

A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Barker, E. D., Walton, E., Cecil, C. A. M., Rowe, R., Jaffee, S. R., Maughan, B., O'Connor, T. G., Stringaris, A., Meehan, A. J., McArdle, W., Relton, C. L. & Gaunt, T. R., Sep 2018, In : Child Development. 89, 5, p. 1839-1855 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
210 Downloads (Pure)

Association of copy number variation across the genome with neuropsychiatric traits in the general population

Guyatt, A. L., Stergiakouli, E., Martin, J., Walters, J., O'Donovan, M., Owen, M., Thapar, A., Kirov, G., Rodriguez, S., Rai, D., Zammit, S. & Gaunt, T. R., Jul 2018, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 177, 5, p. 489-502 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
211 Downloads (Pure)

Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women

Guyatt, A. L., Burrows, K., Guthrie, P. A. I., Ring, S., McArdle, W., Day, I. N. M., Ascione, R., Lawlor, D. A., Gaunt, T. R. & Rodriguez, S., 1 Mar 2018, In : Mitochondrion. 39, p. 9-19 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
267 Downloads (Pure)

DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival

Ambatipudi, S., Langdon, R., Richmond, R. C., Suderman, M., Koestler, D. C., Kelsey, K. T., Kazmi, N., Penfold, C., Ho, K. M., McArdle, W., Ring, S. M., Pring, M., Waterboer, T., Pawlita, M., Gaunt, T. R., Davey Smith, G., Thomas, S., Ness, A. R. & Relton, C. L., 1 Oct 2018, In : Oral Oncology. 85, p. 87-94 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
222 Downloads (Pure)

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis

Guyatt, A. L., Rodriguez, S., Gaunt, T. R., Fraser, A. & Anderson, E. L., 7 Aug 2018, In : Wellcome Open Research. 2, p. 118

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

FATHMM-XF: accurate prediction of pathogenic point mutations via extended features

Rogers, M., Shihab, H. A., Mort, M., Cooper, D. N., Gaunt, T. & Campbell, C., 1 Feb 2018, In : Bioinformatics. 34, 3, p. 511-513 3 p., btx536.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
49 Citations (Scopus)
438 Downloads (Pure)

Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

Cuellar-Partida, G., Laurin, C., Ring, S., Gaunt, T., McRae, A., Visscher, P. M., Montgomery, G., Martin, N. G., Hemani, G., Suderman, M., Relton, C., Davey Smith, G. & Evans, D., Aug 2018, In : Human Molecular Genetics. 27, 16, p. 2927-2939 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
217 Downloads (Pure)

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

Barker, E. D., Cecil, C. A. M., Walton, E., Houtepen, L. C., O'Connor, T. G., Danese, A., Jaffee, S. R., Jensen, S. K. G., Pariante, C., McArdle, W., Gaunt, T. R., Relton, C. L. & Roberts, S., Aug 2018, In : Development and Psychopathology. 30, 3, p. 1145-1156 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
287 Downloads (Pure)

Longitudinal analysis strategies for modelling epigenetic trajectories

Staley, J. R., Suderman, M., Simpkin, A., Gaunt, T., Heron, J., Relton, C. & Tilling, K., 16 Feb 2018, In : International Journal of Epidemiology. 23 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
234 Downloads (Pure)

MELODI: Mining Enriched Literature Objects to Derive Intermediates

Elsworth, B., Dawe, K., Vincent, E., Langdon, R., Lynch, B., Martin, R., Relton, C., Higgins, J. & Gaunt, T., Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 369–379 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
248 Downloads (Pure)

Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study

Cecil, C. A. M., Walton, E., Jaffee, S. R., O'Connor, T., Maughan, B., Relton, C. L., Smith, R. G., McArdle, W., Gaunt, T. R., Ouellet-Morin, I. & Barker, E. D., 1 May 2018, In : Development and Psychopathology. p. 383-397 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
343 Downloads (Pure)

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

Zheng, J., Richardson, T., Millard, L., Hemani, G., Elsworth, B., Raistrick, C., Vilhjalmsson, B., Neale, B. M., Haycock, P., Davey Smith, G. & Gaunt, T., Aug 2018, In : GigaScience. 7, 8, 10 p., giy090.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
206 Downloads (Pure)

Psychosocial adversity and socioeconomic position during childhood and epigenetic age: Analysis of two prospective cohort studies

Lawn, R. B., Anderson, E. L., Suderman, M., Simpkin, A. J., Gaunt, T. R., Teschendorff, A. E., Widschwendter, M., Hardy, R., Kuh, D., Relton, C. L. & Howe, L. D., 1 Apr 2018, In : Human Molecular Genetics. 27, 7, p. 1301-1308 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
184 Downloads (Pure)
Open Access
File
16 Citations (Scopus)
220 Downloads (Pure)
Open Access
File
18 Citations (Scopus)
181 Downloads (Pure)
Open Access
File
14 Citations (Scopus)
216 Downloads (Pure)

The MR-Base platform supports systematic causal inference across the human phenome

Hemani, G., Zheng, J., Elsworth, B., Wade, K., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., Tan, V., Yarmolinsky, J., Shihab, H., Timpson, N., Evans, D., Relton, C., Martin, R., Davey Smith, G., Gaunt, T. & Haycock, P., 30 May 2018, In : eLife. 7, 29 p., e34408.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
261 Citations (Scopus)
292 Downloads (Pure)