20002020

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Article (Academic Journal)
2020

ANNALS EXPRESS: Establishing reference intervals for triglyceride containing lipoprotein sub-fraction metabolites measured using Nuclear Magnetic Resonance Spectroscopy in a UK population

Joshi, R., Lawlor, D. A., Wannamethee, S. G., Engmann, J., Gaunt, T. R., Price, J. F., Papacosta, O., Shah, T., Tillin, T., Whincup, P., Chaturvedi, N., Kivimaki, M. J., Kuh, D., Kumari, M., Hughes, A. D., Casas, J-P., Humphries, S. E., Hingorani, A. D. & Schmidt, A. F., 16 Sep 2020, In : Annals of Clinical Biochemistry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Downloads (Pure)

Associations Between High Blood Pressure and DNA Methylation

Kazmi, N., Elliott, H. R., Burrows, K., Tillin, T., Hughes, A. D., Chaturvedi, N., Gaunt, T. R. & Relton, C. L., 30 Jan 2020, In : PLoS ONE. 15, 1, 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
80 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
77 Downloads (Pure)
Open Access
File
53 Downloads (Pure)

CScape-somatic: distinguishing driver and passenger point mutations in the cancer genome

Rogers, M. F., Gaunt, T. R. & Campbell, C., 13 Apr 2020, In : Bioinformatics. btaa242.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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26 Downloads (Pure)

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran, P., Timpson, N. J., Staley, J. R., Richardson, T. G., Davey Smith, G., Gaunt, T. R., Relton, C. L., Howson, J. M. M. & Munroe, P. B., 9 Sep 2020, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle (Academic Journal)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

Cho, Y., Haycock, P. C., Sanderson, E., Gaunt, T. R., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 21 Feb 2020, In : Nature Communications. 11, 13 p., 1010 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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64 Downloads (Pure)

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage

Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators, Mar 2020, In : Journal of Neurology, Neurosurgery, and Psychiatry. 91, 3, p. 305-313 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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40 Downloads (Pure)

Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage

Hostettler, I. C., Morton, M. J., Ambler, G., Kazmi, N., Gaunt, T. R., Wilson, D., Shakeshaft, C., Jäger, H. R., Cohen, H., Yousry, T., Salman, R. A-S., Lip, G. Y. H., Brown, M., Muir, K. W., Houlden, H., Bulters, D. O., Galea, I. & Werring, D. J., 10 Jan 2020, In : Journal of Neurology, Neurosurgery, and Psychiatry. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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64 Downloads (Pure)

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

Langdon, R. J., Richmond, R. C., Elliott, H. R., Dudding, T., Kazmi, N., Penfold, C., Ingarfield, K., Ho, K. M., Bretherick, A. D., Haley, C. S., Zeng, Y., Walker, R., Pawlita, M., Waterboer, T., Gaunt, T. R., Davey Smith, G., Suderman, M. J., Thomas, S. J., Ness, A. R. & Relton, C. L., 29 Jun 2020, In : Clinical Epigenetics. 12, 19 p., 95 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Downloads (Pure)

MELODI Presto: A fast and agile tool to explore semantic triples derived from biomedical literature

Elsworth, B. L. & Gaunt, T. R., 5 Aug 2020, (Accepted/In press) In : Bioinformatics.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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41 Downloads (Pure)

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

Zheng, J., Haberland, V., Baird, D. A., Walker, V. M., Haycock, P. C., Hurle, M. R., Gutteridge, A., Erola, P., Liu, Y., Luo, S., Robinson, J. W., Richardson, T. G., Staley, J. R., Elsworth, B. L., Burgess, S., Sun, B. B., Danesh, J., Runz, H., Maranville, J. C., Martin, H. M. & 14 others, Yarmolinsky, J., Laurin, C. A., Holmes, M. V., Liu, J. Z., Estrada, K., Santos, R., McCarthy, L., Waterworth, D., Nelson, M. R., Davey Smith, G., Butterworth, A. S., Hemani, G., Scott, R. A. & Gaunt, T. R., 7 Sep 2020, In : Nature Genetics.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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56 Downloads (Pure)

Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults

Joshi, R., Wannamethee, S. G., Engmann, J., Gaunt, T., Lawlor, D. A., Price, J., Papacosta, O., Shah, T., Tillin, T., Chaturvedi, N., Kivimaki, M., Kuh, D., Kumari, M., Hughes, A. D., Casas, J. P., Humphries, S., Hingorani, A. D. & Schmidt, A. F., 29 Jan 2020, In : European Journal of Preventive Cardiology. p. 2047487319899621

Research output: Contribution to journalArticle (Academic Journal)

2019

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

Guyatt, A. L., Brennan, R. R., Burrows, K., Guthrie, P. A. I., Ascione, R., Ring, S. M., Gaunt, T. R., Pyle, A., Cordell, H. J., Lawlor, D. A., Chinnery, P. F., Hudson, G. & Rodriguez, S., 31 Jan 2019, In : Human Genomics. 13, 17 p., 6.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
216 Downloads (Pure)

Appraising the causal relevance of DNA methylation for risk of lung cancer

Battram, T., Richmond, R., Baglietto, L., Haycock, P., Perduca, V., Bojensen, S., Gaunt, T., Hemani, G., Guida, F., Carreras-Torres, R., Hung, R. J., Amos, C. I., Freeman, J., Sandanger, T. M., Nøst, T., Nordestgaard, B. G., Teschendorff, A. E., Polidoro, S., Vineis, P., Severi, G. & 7 others, Hodge, A., Giles, G. G., Grankvist, K., Johansson, M., Johansson, M., Davey Smith, G. & Relton, C., 24 Sep 2019, In : International Journal of Epidemiology. 12 p., dyz190.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
142 Downloads (Pure)

Estimating the Frequency of Single Point Driver Mutations across Common Solid Tumours

Darbyshire, M., du Toit, Z., Rogers, M. F., Gaunt, T. R. & Campbell, C., 17 Sep 2019, In : Scientific Reports. 9, 11 p., 13452 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
166 Downloads (Pure)

Genetic determinants of circulating haptoglobin concentration

Kazmi, N., Koda, Y., Ndiaye, N. C., Visvikis-Siest, S., Morton, M. J., Gaunt, T. R. & Galea, I., 1 Jul 2019, In : Clinica Chimica Acta. 494, p. 138-142 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
220 Downloads (Pure)

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns: Findings From the Pregnancy and Childhood Epigenetics Consortium

Kazmi, N., Sharp, G. C., Reese, S. E., Vehmeijer, F. O., Lahti, J., Page, C. M., Zhang, W., Rifas-Shiman, S. L., Rezwan, F. I., Simpkin, A. J., Burrows, K., Richardson, T. G., Santos Ferreira, D. L., Fraser, A., Harmon, Q. E., Zhao, S., Jaddoe, V. W. V., Czamara, D., Binder, E. B., Magnus, M. C. & 23 others, Håberg, S. E., Nystad, W., Nohr, E. A., Starling, A. P., Kechris, K. J., Yang, I. V., DeMeo, D. L., Litonjua, A. A., Baccarelli, A., Oken, E., Holloway, J. W., Karmaus, W., Arshad, S. H., Dabelea, D., Sørensen, T. I. A., Laivuori, H., Raikkonen, K., Felix, J. F., London, S. J., Hivert, M. F., Gaunt, T. R., Lawlor, D. A. & Relton, C. L., 1 Aug 2019, In : Hypertension. 74, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
161 Downloads (Pure)

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

arcOGEN Consortium, 1 Feb 2019, In : Nature Genetics. 51, 2, p. 230-236 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
48 Citations (Scopus)
154 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
170 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
288 Downloads (Pure)

Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study

De Silva, M., Borges, C., Hingorani, A., Engmann, J., Shah, T., Zhang, X., Luan, J., Langenberg, C., Wong, A., Kuh, D., Chambers, J. C., Zhang, W., Jarvelin, M-R., Sebert, S., Auvinen, J., UCLEB Consortium, Gaunt, T. & Lawlor, D., 1 Aug 2019, In : Diabetes. 68, 8, p. 1681-1691 11 p., db181048.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
420 Downloads (Pure)

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Haworth, S., Shapland, C. Y., Hayward, C., Prins, B. P., Felix, J. F., Medina-Gomez, C., Rivadeneira, F., Wang, C., Ahluwalia, T. S., Vrijheid, M., Guxens, M., Sunyer, J., Tachmazidou, I., Walter, K., Iotchkova, V., Jackson, A., Cleal, L., Huffmann, J., Min, J. L., Sass, L. & 7 others, Timmers, P. R. H. J., UK10K Consortium, Davey Smith, G., Cole, T. J., Timpson, N., Zeggini, E. & St Pourcain, B., 21 Jan 2019, In : Nature Communications. 10, 16 p., 357.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
146 Downloads (Pure)

MR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways

Cho, Y., Haycock, P., Gaunt, T., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 2019, (Submitted) In : Nature Communications.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
224 Downloads (Pure)
Open Access
File
14 Citations (Scopus)
242 Downloads (Pure)
Open Access
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3 Citations (Scopus)
192 Downloads (Pure)
2018

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Slieker, R., Relton, C., Gaunt, T., Slagboom, P. E. & Heijmans, B. T., 30 May 2018, In : Epigenetics and Chromatin. 11, 1, 11 p., 25.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
36 Citations (Scopus)
255 Downloads (Pure)

A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Barker, E. D., Walton, E., Cecil, C. A. M., Rowe, R., Jaffee, S. R., Maughan, B., O'Connor, T. G., Stringaris, A., Meehan, A. J., McArdle, W., Relton, C. L. & Gaunt, T. R., Sep 2018, In : Child Development. 89, 5, p. 1839-1855 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
227 Downloads (Pure)

Association of copy number variation across the genome with neuropsychiatric traits in the general population

Guyatt, A. L., Stergiakouli, E., Martin, J., Walters, J., O'Donovan, M., Owen, M., Thapar, A., Kirov, G., Rodriguez, S., Rai, D., Zammit, S. & Gaunt, T. R., Jul 2018, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 177, 5, p. 489-502 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
220 Downloads (Pure)

Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women

Guyatt, A. L., Burrows, K., Guthrie, P. A. I., Ring, S., McArdle, W., Day, I. N. M., Ascione, R., Lawlor, D. A., Gaunt, T. R. & Rodriguez, S., 1 Mar 2018, In : Mitochondrion. 39, p. 9-19 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
279 Downloads (Pure)

DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival

Ambatipudi, S., Langdon, R., Richmond, R. C., Suderman, M., Koestler, D. C., Kelsey, K. T., Kazmi, N., Penfold, C., Ho, K. M., McArdle, W., Ring, S. M., Pring, M., Waterboer, T., Pawlita, M., Gaunt, T. R., Davey Smith, G., Thomas, S., Ness, A. R. & Relton, C. L., 1 Oct 2018, In : Oral Oncology. 85, p. 87-94 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
267 Downloads (Pure)

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis

Guyatt, A. L., Rodriguez, S., Gaunt, T. R., Fraser, A. & Anderson, E. L., 7 Aug 2018, In : Wellcome Open Research. 2, p. 118

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

FATHMM-XF: accurate prediction of pathogenic point mutations via extended features

Rogers, M., Shihab, H. A., Mort, M., Cooper, D. N., Gaunt, T. & Campbell, C., 1 Feb 2018, In : Bioinformatics. 34, 3, p. 511-513 3 p., btx536.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
63 Citations (Scopus)
464 Downloads (Pure)

Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

Cuellar-Partida, G., Laurin, C., Ring, S., Gaunt, T., McRae, A., Visscher, P. M., Montgomery, G., Martin, N. G., Hemani, G., Suderman, M., Relton, C., Davey Smith, G. & Evans, D., Aug 2018, In : Human Molecular Genetics. 27, 16, p. 2927-2939 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
229 Downloads (Pure)

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

Barker, E. D., Cecil, C. A. M., Walton, E., Houtepen, L. C., O'Connor, T. G., Danese, A., Jaffee, S. R., Jensen, S. K. G., Pariante, C., McArdle, W., Gaunt, T. R., Relton, C. L. & Roberts, S., Aug 2018, In : Development and Psychopathology. 30, 3, p. 1145-1156 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
307 Downloads (Pure)

Longitudinal analysis strategies for modelling epigenetic trajectories

Staley, J. R., Suderman, M., Simpkin, A., Gaunt, T., Heron, J., Relton, C. & Tilling, K., 16 Feb 2018, In : International Journal of Epidemiology. 23 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
241 Downloads (Pure)

MELODI: Mining Enriched Literature Objects to Derive Intermediates

Elsworth, B., Dawe, K., Vincent, E., Langdon, R., Lynch, B., Martin, R., Relton, C., Higgins, J. & Gaunt, T., Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 369–379 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
266 Downloads (Pure)

Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study

Cecil, C. A. M., Walton, E., Jaffee, S. R., O'Connor, T., Maughan, B., Relton, C. L., Smith, R. G., McArdle, W., Gaunt, T. R., Ouellet-Morin, I. & Barker, E. D., 1 May 2018, In : Development and Psychopathology. p. 383-397 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
361 Downloads (Pure)

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

Zheng, J., Richardson, T., Millard, L., Hemani, G., Elsworth, B., Raistrick, C., Vilhjalmsson, B., Neale, B. M., Haycock, P., Davey Smith, G. & Gaunt, T., Aug 2018, In : GigaScience. 7, 8, 10 p., giy090.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
225 Downloads (Pure)

Psychosocial adversity and socioeconomic position during childhood and epigenetic age: Analysis of two prospective cohort studies

Lawn, R. B., Anderson, E. L., Suderman, M., Simpkin, A. J., Gaunt, T. R., Teschendorff, A. E., Widschwendter, M., Hardy, R., Kuh, D., Relton, C. L. & Howe, L. D., 1 Apr 2018, In : Human Molecular Genetics. 27, 7, p. 1301-1308 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
200 Downloads (Pure)
Open Access
File
18 Citations (Scopus)
240 Downloads (Pure)
Open Access
File
19 Citations (Scopus)
196 Downloads (Pure)
Open Access
File
15 Citations (Scopus)
232 Downloads (Pure)

The MR-Base platform supports systematic causal inference across the human phenome

Hemani, G., Zheng, J., Elsworth, B., Wade, K., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., Tan, V., Yarmolinsky, J., Shihab, H., Timpson, N., Evans, D., Relton, C., Martin, R., Davey Smith, G., Gaunt, T. & Haycock, P., 30 May 2018, In : eLife. 7, 29 p., e34408.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
321 Citations (Scopus)
340 Downloads (Pure)
2017

An integrative approach to predicting the functional effects of small indels in non-coding regions of the human genome

Ferlaino, M., Rogers, M. F., Shihab, H. A., Mort, M., Cooper, D. N., Gaunt, T. R. & Campbell, C., 6 Oct 2017, In : BMC Bioinformatics. 18, 1, 442.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
267 Downloads (Pure)