Projects per year
I'm a computational evolutionary biologist. Work in my group uses computational methods (mostly phylogenetics and bioinformatics) to study how molecules, genomes and microbes evolve, and to learn about the evolutionary history of life.
Current group members include
- Dr. Celine Petitjean (NERC PDRA): eukaryote phylogeny and genome evolution
- Dr. Paul O. Sheridan (NERC PDRA, with Cecile Gubry-Rangin, Aberdeen): genome evolution of Thaumarchaeota
- Dr. Christopher Kay (BBSRC PDRA, with Wendy Gibson, Bristol): trypanosome genomics
- Gareth Coleman (Royal Society PhD student): bacterial evolution
- Edd Moody (Royal Society PhD student): evolution of protein folds
- Brogan Harris (PhD student, with Alistair Hetherington, Bristol): gene family evolution in land plants
- James Fearn (PhD student, with Colin Campbell, Bristol): machine learning approaches to biological data analysis
- Matt Tarnowski (PhD student, with Tom Gorochowski, Bristol): using evolutionary information in synthetic biology
- Hend Abu Elmakarem Abdelrahman (MSc Res student): genomics of free-living eukaryotic microbes
- Kate Cook (MSc Res student): evolution of trypanosome genome structure
- Erika Griss Pascuali (MSc Res student): eukaryote evolution
- Ross Scambler (MSc Res student): excavate comparative genomics
Get in touch if you are interested in joining; I also take interested Masters students from Biological Sciences and Earth Sciences.
Early cellular evolution
I'm fascinated by the earliest stages of cell evolution, including the origins of bacteria, archaea, eukaryotes, and the relationships between them. I am applying phylogenetic and comparative genomic approaches to reconstruct the common ancestors of these groups and to draw inferences about the conditions in which they evolved on the early Earth. Working back from modern genomes to understand ancient events challenges current methods to their limits, and so I work with statisticians to develop and apply new approaches that bring new kinds of data to bear on these challenging problems.
The origin of eukaryotes
I maintain a long-term interest in the origin of eukaryotic cells --- the compartmentalized cells containing a mitochondrion and nucleus that form the basis for the complex life we see around us every day, from a diversity of single-celled forms through plants, fungi, and animals, including humans. The balance of evidence now places a symbiosis between an archaeal host cell and a bacterial endosymbiont --- members of the two major prokaryotic domains --- as a foundational event in the origin of eukaryotes. Much of my work in recent years has focused on testing hypotheses for eukaryote origins, and ongoing work at Bristol involves identifying our closest archaeal relatives and working out how the complex cellular features of modern eukaryotes evolved from their prokaryotic progenitors.
Eukaryotic genome diversity and evolution
While to many of us, the most familiar eukaryotes are the four main multicellular lineages --- plants, animals, fungi and brown algae --- the great majority of eukaryotic genetic diversity is found among single-celled forms, and several of the most biodiverse eukaryotic groups are entirely unicellular. Current work focuses on comparative genomics of two groups in particular: (i) the microsporidians, obligate intracellular parasites related to fungi, which are fascinating model systems for studying the limits of eukaryotic genome reduction; and (ii) the excavates, a very diverse and poorly-understood group of microbial eukaryotes that contains both serious parasites (trypanosomes, Giardia, Trichomonas), as well as abundant and ecologically important free-living forms.
1/12/17 → 30/09/21
15/09/17 → 14/03/21
Antón, Z., Weijman, J. F., Williams, C., Moody, E. R. R., Mantell, J., Yip, Y. Y., Cross, J. A., Williams, T. A., Steiner, R. A., Crump, M., Woolfson, D. N. & Dodding, M. P., 21 Jan 2021, In: bioRxiv.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewFile30 Downloads (Pure)
Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humansFerguson, D. C. J., Haji Mokim, J., Meinders, M., Moody, E. R. R., Williams, T. A., Trakarnsanga, K., Daniels, D. E., Ferrer-Vicens, I., Shoemark, D., Tipgomut, C., Macinnes, K. A., Wilson, M. C., Singleton, B. K. & Frayne, J., 5 Oct 2020, In: Haematologica.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Williams, T. & Gubry-Rangin, C., 30 Oct 2020, In: Nature Communications. 11, 12 p., 5494 (2020) .
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile24 Downloads (Pure)