Tracey J Collard

2024

Identifying targetable metabolic dependencies across colorectal cancer progression

Legge, D. N., Collard, T. J., Stanko, E., Hoskin, A. J., Holt, A. K., Bull, C. J., Kollareddy, M., Bellamy, J., Groves, S., Ma, E. H., Hazelwood, E., Qualtrough, D., Amulic, B., Malik, K., Williams, A. C., Jones, N. & Vincent, E. E., 1 Dec 2024, In: Molecular metabolism. 90, p. 1-18 18 p., 102037.

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3 Downloads (Pure)

2023

Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer

Hoskin, A. J., Holt, A. K., Legge, D. N., Collard, T. J., Williams, A. C. & Vincent, E. E., 28 Aug 2023, In: Exploration of Targeted Anti-tumor Therapy. 4, p. 600–615 15 p.

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Open Access

3 Citations (Scopus)

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Holt, A. K., Collard, T. J., Hoskin, A. J., Legge, D. N., Mortensson, E. M. H., Kollareddy, M., Timms, P., Williams, A. C. & Vincent, E. E., 19 Oct 2023, (E-pub ahead of print) In: BMC Cancer & Metabolism.

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16 Downloads (Pure)

2022

BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination

Parker, C., Chambers, A. C., Flanagan, D. J., Ho, J. W. Y., Collard, T. J., Ngo, G., Baird, D. M., Timms, P., Morgan, R. G., Sansom, O. J. & Williams, A. C., 1 Jul 2022, In: DNA repair. 115, 11 p., 103331.

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5 Citations (Scopus)

256 Downloads (Pure)

2021

5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: implications for chemoprophylaxis in colorectal tumorigenesis

Dixon, S. W., Collard, T. J., Mortensson, E. M. H., Legge, D. N., Chambers, A. C., Greenhough, A., Creed, T. J. & Williams, A. C., 8 Jun 2021, In: British Journal of Cancer. 124, 12, p. 1959-1969 11 p.

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8 Citations (Scopus)

118 Downloads (Pure)

2020

BCL–3 promotes cyclooxygenase–2/prostaglandin E₂ signalling in colorectal cancer

Collard, T. J., Fallatah, H. M., Greenhough, A., Paraskeva, C. & Williams, A. C., 1 May 2020, In: International Journal of Oncology. 56, 5, p. 1304-1313 10 p.

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6 Citations (Scopus)

172 Downloads (Pure)

The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis

Legge, D. N., Chambers, A. C., Parker, C. T., Timms, P., Collard, T. J. & Williams, A. C., 13 Jan 2020, (E-pub ahead of print) In: Carcinogenesis. 8 p., bgaa003.

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25 Citations (Scopus)

136 Downloads (Pure)

2019

BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

Legge, D., Shephard, A., Collard, T., Greenhough, A., Chambers, A., Clarkson, R., Paraskeva, C. & Williams, A., 4 Mar 2019, In: Disease Models and Mechanisms. 12, 3, 12 p., dmm037697.

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28 Citations (Scopus)

294 Downloads (Pure)

2018

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis

Greenhough, A., Bagley, C., Heesom, K., Gurevich, D., Gay, D., Bond, M., Collard, T., Paraskeva, C., Martin, P., Sansom, O. J., Malik, K. & Williams, A., 1 Nov 2018, In: EMBO Molecular Medicine. 10, 11, 13 p., e8699.

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67 Citations (Scopus)

439 Downloads (Pure)

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity

Morgan, R. G., Mortensson, E., Legge, D. N., Gupta, B., Collard, T. J., Greenhough, A. & Williams, A. C., 20 Feb 2018, In: British Journal of Cancer. 118, 4, p. 558-565 8 p.

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11 Citations (Scopus)

326 Downloads (Pure)

2016

BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling

Urban, B. C., Collard, T. J., Eagle, C. J., Southern, S. L., Greenhough, A., Hamdollah-Zadeh, M., Ghosh, A., Poulsom, R., Paraskeva, C., Silver, A. & Williams, A. C., 3 Jun 2016, In: Gut. 65, p. 1151-1164

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37 Citations (Scopus)

2015

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

Morgan, R. G., Molnar, E., Jones, R. F., Collard, T. J., Lane, J. D., Greenhough, A., Paraskeva, C. & Williams, A. C., 17 Feb 2015, In: British Journal of Cancer. 112, 4, p. 714-719 6 p.

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13 Citations (Scopus)

358 Downloads (Pure)

2013

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez-Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J., Batson, J., Malik, K., Paraskeva, C. & Greenhough, A., 4 Jun 2013, In: EMBO Journal. 32, 13, p. 1903 - 1916 14 p.

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253 Citations (Scopus)

BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells

Skeen, V. R., Collard, T. J., Southern, S. L., Greenhough, A., Hague, A., Townsend, P., Paraskeva, C. & Williams, A. C., 19 Sept 2013, In: Oncogene. 32, 38, p. 4490-4499 10 p.

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17 Citations (Scopus)

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs

Al-Kharusi, M. R. A., Smartt, H. J. M., Greenhough, A., Collard, T. J., Emery, E. D., Williams, A. C. & Paraskeva, C., 2013, In: Carcinogenesis.

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60 Citations (Scopus)

2012

BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis

Southern, S. L., Collard, T. J., Urban, B. C., Skeen, V. R., Smartt, H. J., Hague, A., Oakley, F., Townsend, P. A., Perkins, N. D., Paraskeva, C. & Williams, A. C., 2012, In: Oncogene. 31, 22, p. 2761-2772 12 p.

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26 Citations (Scopus)

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the antiapoptotic function of BAG-1 protein in colorectal tumour cells: Rb increases nuclear localisation and function of BAG-1

Collard, T. J., Urban, B. C., Patsos, H. A., Hague, A., Paraskeva, C., Williams, A. C. & Townsend, P., 11 Oct 2012, In: Cell Death and Disease. 3, 9 p., e408.

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34 Citations (Scopus)

497 Downloads (Pure)

β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

Smartt, H. J. M., Greenhough, A., Ordóñez-Morán , P., Al Kharusi, M. R. A., Collard, T. J., Mariadason, J., Huelsken, J., Williams, A. C. & Paraskeva, C., 23 Oct 2012, In: British Journal of Cancer. 107, 9, p. 1514-1517

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10 Citations (Scopus)

2010

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Patsos, H., Greenhough, A., Hicks, D., Al kharusi, M., Collard, T., Lane, J., Paraskeva, C. & Williams, A., Jul 2010, In: International Journal of Oncology. 37 (5), p. 187 - 193 7 p.

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71 Citations (Scopus)

2008

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-κB activity

Clemo, N., Collard, T., Southern, S., Edwards, K., Moorghen, M., Packham, G., Hague, A., Paraskeva, C. & Williams, A., Apr 2008, In: Carcinogenesis. 29, 4, p. 849 - 857 9 p.

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51 Citations (Scopus)

2007

Insulin-like growth factor binding protein (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-κB

Williams, A., Smartt, H., H-Zadeh, A., MacFarlane, M., Paraskeva, C. & Collard, T., Jan 2007, In: Cell Death and Differentiation. 14 (1), p. 137 - 145 9 p.

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59 Citations (Scopus)

2006

Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells

H-Zadeh, A., Collard, T., Malik, K., Hicks, D., Paraskeva, C. & Williams, A., Nov 2006, In: International Journal of Oncology. 29 (5), p. 1279 - 1286 8 p.

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20 Citations (Scopus)

Miss Tracey J Collard

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