Varinder K Aggarwal

2025

A Simple NMR-Based Rule for Stereochemical Assignment of 1,5-Diols in Polyketides

Deering, M. W., George, M. R. P., Butts, C. P. & Aggarwal, V. K., 12 Mar 2025, (E-pub ahead of print) In: Chemistry Europe. 6 p., e202500044.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Iridium-Catalyzed Stereocontrolled C(sp 3)–C(sp3) Cross-Coupling of Boronic Esters and Allylic Carbonates Enabled by Boron-to-Zinc Transmetalation

Shen, H.-C. & Aggarwal, V. K., 6 Feb 2025, In: Journal of the American Chemical Society. 147, 7, p. 5583-5589 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A

George, M. R. P., Deering, M. W., Fiorito, D., Solomon, K., Tridgewell, K., Noble, A., Butts, C. P. & Aggarwal, V. K., 13 Mar 2025, (E-pub ahead of print) In: Nature Synthesis.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2024

Difluorinated thromboxane A₂ reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

Allen, M. F., Hutchinson, J. L., Keith, M. R. W., Mallah, S., Corey, R. A., Trory, J. S., Jing, C., Fang, H., Wei, L., Bennett, S. H., Aggarwal, V. K., Mundell, S. J. & Hers, I., 5 Jun 2024, (E-pub ahead of print) In: British Journal of Pharmacology. 181, 19, p. 3685-3699 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Merging Organocatalysis with 1,2-Boronate Rearrangement: A Lewis Base-Catalyzed Asymmetric Multicomponent Reaction

Shen, H.-C. & Aggarwal, V. K., 9 Oct 2024, In: Journal of the American Chemical Society. 146, 40, p. 27305-27311 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Platinum‐catalyzed regio‐ and enantioselective diboration of unactivated alkenes with (pin)B−B(dan)

Fang, H., Manoj, N., Popescu, M., Noble, A., Paton, R. & Aggarwal, V. K., 14 Aug 2024, (E-pub ahead of print) In: Angewandte Chemie International Edition. 64, 1, e202413504.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Simultaneous Stereoinvertive and Stereoselective C(sp3)–C(sp3) Cross-Coupling of Boronic Esters and Allylic Carbonates

Shen, H.-C., Wang, Z.-S., Noble, A. & Aggarwal, V. K., 22 May 2024, In: Journal of the American Chemical Society. 146, 20, p. 13719-13726 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

5 Citations (Scopus)

Synthesis of 1‐azabicyclo[2.1.1]hexanes via formal single electron reduction of azabicyclo[1.1.0]butanes under photochemical conditions

Zanini, M., Noble, A. & Aggarwal, V. K., 23 Oct 2024, In: Angewandte Chemie International Edition. 63, 44, e202410207.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

6 Citations (Scopus)

9 Downloads (Pure)

2023

Application of Enantioselective Sulfur Ylide Epoxidation to a Short Asymmetric Synthesis of Bedaquiline, a Potent Anti-Tuberculosis Drug

Bashir, M., Arshad, M., Begum, R. & Aggarwal, V. K., 16 Jun 2023, In: Organic Letters. 25, 23, p. 4281–4285 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Conformationally Controlled sp3‐Hydrocarbon‐Based α‐Helix Mimetics

Dewis, L. I., Madhavachary, R., Williams, C., Chiarparin, E., Myers, E. L., Butts, C. P. & Aggarwal, V. K., 24 May 2023, In: Angewandte Chemie - International Edition. 62, 23, e202301209.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Convergent Deboronative and Decarboxylative Phosphonylation Enabled by the Phosphite Radical Trap “BecaP”

Pagire, S. K., Shu, C., Reich, D., Noble, A. & Aggarwal, V. K., 23 Aug 2023, In: Journal of the American Chemical Society. 145, 33, p. 18649-18657 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

27 Citations (Scopus)

Copper-Mediated Dehydrogenative C(sp3)–H Borylation of Alkanes

Sang, R., Han, W., Zhang, H., Saunders, C. M., Noble, A. & Aggarwal, V. K., 19 Jul 2023, In: Journal of the American Chemical Society. 145, 28, p. 15207–15217 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

39 Citations (Scopus)

De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost

Wang, Z.-S., Bennett, S. H., Kicin, B., Jing, C., Pradeilles, J. A., Thai, K., Smith, J. R., Bacoş, P. D., Fasano, V., Saunders, C. M. & Aggarwal, V. K., 28 Jun 2023, In: Journal of the American Chemical Society. 145, 25, p. 14124–14132 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

6 Citations (Scopus)

Iridium-Catalyzed Asymmetric Difunctionalization of C–C σ-Bonds Enabled by Ring-Strained Boronate Complexes

Shen, H.-C., Popescu, M. V., Wang, Z.-S., De lescure, L., Noble, A., Paton, R. S. & Aggarwal, V. K., 2 Aug 2023, In: Journal of the American Chemical Society. 145, 30, p. 16508–16516 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

37 Citations (Scopus)

Photoredox‐Catalyzed Decarboxylative Bromination, Chlorination and Thiocyanation Using Inorganic Salts

Wu, J., Shu, C., Li, Z., Noble, A. & Aggarwal, V. K., 14 Sept 2023, In: Angewandte Chemie - International Edition. 62, 38, e202309684.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

26 Citations (Scopus)

Stereospecific Conversion of Boronic Esters into Enones using Methoxyallene: Application in the Total Synthesis of 10‐Deoxymethynolide

Chambers, K. J., Sanghong, P., Martos, D. C., Casoni, G., Mykura, R. C., Hari, D. P., Noble, A. & Aggarwal, V. K., 25 Oct 2023, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 62, 50, e202312054.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Strain‐Release Driven Epoxidation and Aziridination of Bicyclo[1.1.0]butanes via Palladium Catalyzed σ‐Bond Nucleopalladation

Wölfl, B., Winter, N., Li, J., Noble, A. & Aggarwal, V. K., 6 Feb 2023, In: Angewandte Chemie - International Edition. 62, 7, 6 p., e202217064.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

33 Citations (Scopus)

Synthesis and Applications of Bicyclo[1.1.0]butyl and Azabicyclo[1.1.0]butyl Organometallics

Tyler, J. & Aggarwal, V. K., 22 May 2023, In: Chemistry - A European Journal. 29, 29, e202300008.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

42 Citations (Scopus)

Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines

Abell, J. C., Bold, C. P., Vicens, L., Jentsch, T., Velasco, N., Tyler, J. L., Straker, R. N., Noble, A. & Aggarwal, V. K., 10 Jan 2023, (E-pub ahead of print) In: Organic Letters. 25, 2, p. 400-404 5 p.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

105 Downloads (Pure)

2022

Application of Lithiation–Borylation to the Total Synthesis of (−)-Rakicidin F

Bold, C. P., Yeung, K., Pape, F., Kaiser, D. & Aggarwal, V. K., 30 Dec 2022, In: Organic Letters. 24, 51, p. 9398-9402

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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5 Citations (Scopus)

23 Downloads (Pure)

Automated stereocontrolled assembly-line synthesis of organic molecules

Fasano, V., Mykura, R. C., Fordham, J. M., Rogers, J. J., Banecki, B., Noble, A. & Aggarwal, V. K., 27 Oct 2022, (E-pub ahead of print) In: Nature Synthesis. 1, p. 902–907

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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28 Citations (Scopus)

133 Downloads (Pure)

Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function

Trory, J. S., Munkacsi, A., Sledz, K., Goudswaard, L., Jackson, M. L., Heesom, K. J., Moore, S. F., Poole, A. W., Nabet, B., Aggarwal, V. K. & Hers, I., 7 Nov 2022, (E-pub ahead of print) In: Blood Advances.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Diastereodivergent Synthesis of Cyclopentyl Boronic Esters Bearing Contiguous Fully Substituted Stereocenters

Fairchild, M., Noble, A. & Aggarwal, V. K., 26 Aug 2022, In: Angewandte Chemie - International Edition. 61, 35, 5 p., e202205816.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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19 Citations (Scopus)

107 Downloads (Pure)

Dual‐Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis

Losacco, G. L., Bennett, R., Ahmad, I. A. H., Barrientos, R. C., Dasilva, J. O., Dong, Y., Schuppe, A. W., Wang, Z., Aiken, S., Mangion, I., Aggarwal, V. K. & Regalado, E. L., 16 Sept 2022, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 61, 45, e202208854.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

18 Citations (Scopus)

Dual Nickel/Photoredox‐Catalyzed Site‐Selective Cross‐Coupling of 1,2‐Bis‐Boronic Esters Enabled by 1,2‐Boron Shifts

Wang, H., Han, W., Noble, A. & Aggarwal, V. K., 2 Jul 2022, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 8 p., e202207988.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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32 Citations (Scopus)

142 Downloads (Pure)

Facile Conversion of α-Amino Acids into α-Amino Phosphonates by Decarboxylative Phosphorylation using Visible-Light Photocatalysis

Reich, D., Noble, A. & Aggarwal, V. K., 5 Sept 2022, In: Angewandte Chemie - International Edition. 61, 37, e202207063.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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34 Citations (Scopus)

176 Downloads (Pure)

Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines

Tyler, J., Noble, A. & Aggarwal, V. K., 14 Dec 2022, In: Angewandte Chemie - International Edition. 61, 52, e202214049.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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24 Citations (Scopus)

60 Downloads (Pure)

Lithiation–borylation methodology in the total synthesis of natural products

Yeung, K., Mykura, R. C. & Aggarwal, V. K., 7 Feb 2022, In: Nature Synthesis. 1, p. 117–126

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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52 Citations (Scopus)

519 Downloads (Pure)

Selective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visible-Light Activation of Electron Donor-Acceptor Complexes

Wang, H., Wu, J., Noble, A. & Aggarwal, V. K., 25 Feb 2022, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 61, 18, e202202061.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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48 Citations (Scopus)

268 Downloads (Pure)

Sequential Photocatalytic Reactions for the Diastereoselective Synthesis of Cyclobutane Scaffolds

Deeprose, M. J., Lowe, M., Noble, A., Booker-milburn, K. I. & Aggarwal, V. K., 14 Jan 2022, In: Organic Letters. 24, 1, p. 137-141 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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19 Citations (Scopus)

123 Downloads (Pure)

Stereocontrolled Total Synthesis of Bastimolide B Using Iterative Homologation of Boronic Esters

Fiorito, D., Keskin, S., Bateman, J. M., George, M., Noble, A. & Aggarwal, V. K., 11 May 2022, In: Journal of the American Chemical Society. 144, 18, p. 7995−8001 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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30 Citations (Scopus)

173 Downloads (Pure)

Strain‐Release‐Driven Friedel‐Crafts Spirocyclization of Azabicyclo[1.1.0]butanes

Tyler, J. L., Noble, A. & Aggarwal, V. K., 17 Jan 2022, In: Angewandte Chemie - International Edition. 61, 3, 7 p., e202114235.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

169 Downloads (Pure)

2021

Chiral Benzothiophene Synthesis via Enantiospecific Coupling of Benzothiophene S‐Oxides with Boronic Esters

Sang, R., Noble, A. & Aggarwal, V. K., 15 Nov 2021, In: Angewandte Chemie - International Edition. 60, 48, p. 25313-25317 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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11 Citations (Scopus)

23 Downloads (Pure)

Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains

Guo, L., Dutton, O. J., Kucukdisli, M., Davy, M., Wagnières, O., Butts, C. P., Myers, E. L. & Aggarwal, V. K., 13 Oct 2021, In: Journal of the American Chemical Society. 143, 40, p. 16682-16692 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

64 Downloads (Pure)

Corrigendum: How Big is the Pinacol Boronic Ester as a Substituent? (Angewandte Chemie International Edition, (2020), 59, 50, (22403-22407), 10.1002/anie.202007776)

Fasano, V., McFord, A. W., Butts, C. P., Collins, B. S. L., Fey, N., Alder, R. W. & Aggarwal, V. K., 6 Sept 2021, In: Angewandte Chemie - International Edition. 60, 37, p. 20087 1 p.

Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review

1 Citation (Scopus)

Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

White, D. H., Noble, A., Booker-Milburn, K. I. & Aggarwal, V. K., 16 Apr 2021, In: Organic Letters. 23, 8, p. 3038-3042 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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37 Citations (Scopus)

115 Downloads (Pure)

Direct Observation of Reactive Intermediates by Time-Resolved Spectroscopy Unravels the Mechanism of a Radical-Induced 1,2-Metalate Rearrangement

Lewis-Borrell, L. J., Sneha, M., Clark, I. P., Fasano, V., Noble, A., Aggarwal, V. K. & Orr-Ewing, A. J., 20 Oct 2021, In: Journal of the American Chemical Society. 143, 41, p. 17191 - 17199 9 p.

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27 Citations (Scopus)

169 Downloads (Pure)

Divergent, Strain‐Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation

Gregson, C. H. U., Noble, A. & Aggarwal, V. K., 22 Mar 2021, In: Angewandte Chemie - International Edition. 60, 13, p. 7360-7365 6 p.

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35 Citations (Scopus)

57 Downloads (Pure)

Highly Diastereoselective Strain-Increase Allylborations: Rapid Access to Alkylidenecyclopropanes and Alkylidenecyclobutanes

Hari, D. P., Madhavachary, R., Fasano, V., Haire, J. & Aggarwal, V. K., 19 May 2021, In: Journal of the American Chemical Society. 143, 19, p. 7462-7470 9 p., 19.

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25 Citations (Scopus)

90 Downloads (Pure)

Origin of stereocontrol in the Matteson reaction: Importance of attractive electrostatic interactions

Fasano, V. & Aggarwal, V. K., 8 Jan 2021, In: Tetrahedron. 78, 4 p., 131810.

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8 Citations (Scopus)

122 Downloads (Pure)

Strain‐Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones

Tyler, J. L., Noble, A. & Aggarwal, V. K., 17 May 2021, In: Angewandte Chemie - International Edition. 60, 21, p. 11824-11829 6 p.

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23 Citations (Scopus)

108 Downloads (Pure)

Studies on the lithiation, borylation, and 1,2‐metalate rearrangement of O‐cycloalkyl 2,4,6‐triisopropylbenzoates

Mykura, R. C., Songara, P., Luc, E., Rogers, J., Stammers, E. & Aggarwal, V. K., 3 May 2021, In: Angewandte Chemie - International Edition. 60, 20, p. 11436-11441 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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11 Citations (Scopus)

108 Downloads (Pure)

Synthesis of Dysoxylactam A Using Iterative Homologation of Boronic Esters

Rogers, J. J. & Aggarwal, V. K., Sept 2021, In: Asian Journal of Organic Chemistry. 10, 9, p. 2338-2341 4 p.

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8 Citations (Scopus)

160 Downloads (Pure)

2020

1,3-Difunctionalizations of [1.1.1]Propellane via 1,2-Metallate Rearrangements of Boronate Complexes

Yu, S., Jing, C., Noble, A. & Aggarwal, V. K., 2 Mar 2020, In: Angewandte Chemie - International Edition. 59, 10, p. 3917-3921 6 p.

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97 Citations (Scopus)

157 Downloads (Pure)

Decarboxylative Conjunctive Cross-coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis

Mega, R. S., Duong, V. K., Noble, A. & Aggarwal, V. K., 9 Mar 2020, In: Angewandte Chemie - International Edition. 59, 11, p. 4375-4379 5 p.

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115 Citations (Scopus)

290 Downloads (Pure)

Difunctionalization of C–C σ Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins

Bennett, S., Fawcett, A., Denton, E., Biberger, T., Fasano, V., Winter, N. & Aggarwal, V. K., 4 Sept 2020, In: Journal of the American Chemical Society. 142, 39, p. 16766–16775 10 p.

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78 Citations (Scopus)

216 Downloads (Pure)

Divergent, stereospecific mono- and difluoromethylation of boronic esters

Fasano, V., Winter, N., Noble, A. & Aggarwal, V. K., 25 May 2020, In: Angewandte Chemie - International Edition. 6 p.

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41 Citations (Scopus)

243 Downloads (Pure)

Enantioselective Total Synthesis of (‐)‐Finerenone using Asymmetric Transfer Hydrogenation

Aggarwal, V. K., Lerchen, A., Gandhamsetty, N., Farrar, E., Winter, N., Platzek, J. & Grayson, M., 23 Nov 2020, In: Angewandte Chemie - International Edition. (2020) 59, 51, p. 23107–23111 5 p.

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11 Citations (Scopus)

181 Downloads (Pure)

How big is the pinacol boronic ester as a substituent?

Aggarwal, V. K., Fasano, V., McFord, A. W., Butts, C. P., Collins, B. S. L., Fey, N. & Alder, R. W., 31 Aug 2020, (E-pub ahead of print) In: Angewandte Chemie - International Edition.

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35 Citations (Scopus)

204 Downloads (Pure)

Iridium-Catalyzed Enantioselective Synthesis of α-Chiral Bicyclo[1.1.1]pentanes by 1,3-Difunctionalization of [1.1.1]Propellane

Yu, S., Jing, C., Noble, A. & Aggarwal, V. K., 17 Jul 2020, In: Organic Letters. 22, 14, p. 5650-5655 6 p.

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27 Citations (Scopus)

150 Downloads (Pure)

Professor Varinder K Aggarwal

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