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Dr Wael Kafienah leads a team focused on understanding the molecular biology of stem cells for applications in skeletal tissue engineering. He has many years of experience in the UK and US developing methods for cartilage tissue engineering using stem cells. That work lead to significant public (see BBC news story “New hope for arthritis sufferers”) and scientific interest (Arthritis and Rheumatism Journal) and earned him the prestigious Garrod Prize 2008 awarded by the British Society of Rheumatology. The team is building on this work by investigating the more versatile pluripotent stem cells. Dr Kafienah holds 3 patents that resulted recently in a University of Bristol spin-out company (Azellon Cell Therapeutics). He was an executive committee member of the British Society for Matrix Biology.
Specific research interests
- Pharmacological regulation of adult and pluripotent stem cells for cartilage repair and heart disease
- Cartilage tissue engineering using pluripotent stem cells
- Novel biomaterials for tissue engineering and drug delivery
- Endogenous repair of damaged cartilage
- Bacterial-stem cell interactions in osteomyelitis
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- 1 Finished
An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrixCuahtecontzi Delint, R., Day, G. J., Macalester, W. J. P., Kafienah, W., Xiao, W. & Perriman, A. W., Sep 2021, In: Biomaterials. 276, p. 120996 120996.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile2 Citations (Scopus)69 Downloads (Pure)
Chondroinduction of Mesenchymal Stem Cells on Cellulose-Silk Composite nanofibrous Substrates: The Role of Substrate ElasticityBegum, R., Perriman, A., Su, B., Scarpa, F. & Kafienah, W., 19 Mar 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 197.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Citations (Scopus)96 Downloads (Pure)
Bioreactor manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studiesVukasovic, A., Asnaghi, M. A., Kostesic, P., Quasnichka, H. L., Cozzolino, C., Pusic, M., Hails, L., Trainor, N., Krause, C., Figallo, E., Filardo, G., Kon, E., Wixmerten, A., Maticic, D., Pellegrini, G., Kafienah, W., Hudetz, D., Smith, T., Martin, I., Ivkovic, A. & 1 others, , 6 Sep 2019, In: Cell Proliferation. 14 p., e12653.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile7 Citations (Scopus)174 Downloads (Pure)
An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix