Personal profile
Research interests
I am a Post-doctoral Research Associate in Applied Genetic Epidemiology in the Cancer Research UK (CRUK) programme based in the School of Social and Community Medicine. I am currently working on the design and undertaking of Recall by Genotype (RbG) studies under the supervision of Dr Nicholas Timpson. The RbG studies involve the recruitment of a subset of participants or their biosamples from an existing cohort for more detailed phenotypic analysis. The aim of my research is to understand biological mechanisms underlying cancer risk and progression by undertaking the RbG studies.
I did a cross-disciplinary Ph.D. in Cell Biology and Clinical Epidemiology. My Ph.D. research involved using a unique combination of cell biology and epidemiological approaches to better understand the regulation of fascin-1 in cancer and the translational potential of fascin-1, as well as its regulators, as potential cancer biomarkers.
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Collaborations and top research areas from the last five years
Research output
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Adiposity, metabolites and endometrial cancer risk: Inference from combinations of Mendelian randomization and Observational analyses
Tan, Y., Lee, M., Pournaras, D., Wang, S., Gunter, M., Dossus, L., Wade, K. H., Corbin, L. J. & Timpson, N. J., 21 Oct 2025, In: BMC Cancer. 25, 1, 15 p., 1619.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
A Genome-Wide Association Study Using the Bacillus Calmette-Guerin Scar to Elucidate the Genetic Basis of Scarring in a European Population
Collins, I., Canadas Garre, M., Peña, O., Tan, Y., Martin, P. B., Timpson, N. J. & al , E., 1 Oct 2025, p. 21-22. 2 p.Research output: Contribution to conference › Conference Abstract
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The Effect of Circulating Proteins and Their Role in Mediating Adiposity's Effect on Endometrial Cancer Risk: Mendelian Randomization and Colocalization Analyses
Wang, S. E., Tan, V. Y., Yarmolinsky, J., Zheng, Y., O'Mara, T. A., Timpson, N. J., Gunter, M. J., Dossus, L. & Lee, M. A., 1 Sept 2025, In: Cancer Epidemiology Biomarkers and Prevention. 34, 9, p. 1534-1543 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access
Projects
- 1 Active
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Role of directly measured metabolic profile as an intermediate between adiposity and endometrial cancer: triangulation of evidence from independent sources
Timpson, N. J. (Principal Investigator) & Tan, Y. (Co-Principal Investigator)
1/05/23 → 1/05/26
Project: Research
Datasets
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Additional file 2 of Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis
Hazelwood, E. (Creator), Sanderson, E. (Creator), Tan, V. Y. (Creator), Ruth, K. S. (Creator), Frayling, T. M. (Creator), Dimou, N. (Creator), Gunter, M. J. (Creator), Dossus, L. (Creator), Newton, C. (Creator), Ryan, N. (Creator), Pournaras, D. J. (Creator), O’Mara, T. A. (Creator), Davey Smith, G. (Creator), Martin, R. M. (Creator) & Yarmolinsky, J. (Creator), figshare, 19 Apr 2022
DOI: 10.6084/m9.figshare.19613752, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Identifying_molecular_mediators_of_the_relationship_between_body_mass_index_and_endometrial_cancer_risk_a_Mendelian_randomization_analysis/19613752
Dataset
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Genome-wide Association Study of Cancer Risk in UK Biobank
Burrows, K. (Creator), Haycock, P. (Creator), Bull, C. (Contributor), Dudding, T. (Contributor), Gormley, M. (Contributor), Robinson, T. (Contributor), Tan, V. (Contributor) & Yarmolinsky, J. (Contributor), University of Bristol, 23 Nov 2021
DOI: 10.5523/bris.aed0u12w0ede20olb0m77p4b9, http://data.bris.ac.uk/data/dataset/aed0u12w0ede20olb0m77p4b9
Dataset
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Metabolite summary statistics for Mendelian randomization analyses
Langenberg, C. (Creator), Stewart, I. (Creator), Butterworth, A. (Creator), Surendran, P. (Creator), Tan, V. (Creator), Corbin, L. (Creator) & Timpson, N. (Creator), University of Bristol, 9 Sept 2021
DOI: 10.5523/bris.33bq35s9lbos026r1xukxijoqu, http://data.bris.ac.uk/data/dataset/33bq35s9lbos026r1xukxijoqu and one more link, https://data.bris.ac.uk/data/dataset/33bq35s9lbos026r1xukxijoqu (show fewer)
Dataset