Research output per year
Research output per year
Research output
- 21 results
Search results
-
2022
Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG
Zhang, Y. H., Grimwood, A., Hancox, J. C., Harmer, S. C. & Dempsey, C. E., 20 Oct 2022, In: Frontiers in Pharmacology. 13, 24 p., 1010119.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)84 Downloads (Pure) -
The PhanSST global database of Phanerozoic sea surface temperature proxy data
Judd, E. J., Tierney, J. E., Huber, B. T., Wing, S. L., Lunt, D. J., Ford, H. L., Inglis, G. N., McClymont, E. L., O’Brien, C. L., Rattanasriampaipong, R., Si, W., Staitis, M. L., Thirumalai, K., Anagnostou, E., Cramwinckel, M. J., Dawson, R. R., Evans, D., Gray, W. R., Grossman, E. L. & Henehan, M. J. & 6 others, , Dec 2022, In: Scientific Data. 9, 1, 753.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access19 Citations (Scopus) -
2020
An update on the structure of hERG
Butler, A., Helliwell, M. V., Zhang, Y., Hancox, J. C. & Dempsey, C. E., 24 Jan 2020, In: Frontiers in Pharmacology. 10, 13 p., 1572.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile65 Citations (Scopus)237 Downloads (Pure) -
Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment
Al-Moubarak, E., Zhang, Y., Dempsey, C. E., Zhang, H., Harmer, S. C. & Hancox, J. C., 11 Jun 2020, In: Biochemical and Biophysical Research Communications. 526, 4, p. 1085-1091 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile8 Citations (Scopus)165 Downloads (Pure) -
2018
Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome
Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., Sept 2018, In: Physiological Reports. 6, 17, 14 p., e13845.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile10 Citations (Scopus)323 Downloads (Pure) -
An exploration of interactions between the antiarrhythmic drug dronedarone and the hERG potassium channel pore
Zhang, Y. H., Colenso, C., Dempsey, C. & Hancox, J., 31 Aug 2018, In: Journal of Integrative Cardiology. 1, 1, p. 1-9 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile329 Downloads (Pure) -
2016
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
Zhang, Y. H., Colenso, C. K., Harchi, A. E., Cheng, H., Witchel, H. J., Dempsey, C. E. & Hancox, J. C., 1 Aug 2016, In: Biochemical Pharmacology. 113, p. 24-35 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile40 Citations (Scopus)489 Downloads (Pure) -
2015
Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sept 2015, In: Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile51 Citations (Scopus)363 Downloads (Pure) -
2014
Inverstigating Stereoselectivity of Pharmacological Inhibition of Herg Channels
Zhang, Y. H., Harchi, A. E. I., Dempsey, C. E. & Hancox, J. C., 28 Jan 2014, In: Biophysical Journal. 106, 2, p. 139A-139A 1 p.Research output: Contribution to journal › Article (Academic Journal)
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Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants
Du, C., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sept 2014, In: Journal of Molecular and Cellular Cardiology. 74, p. 220-230 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile44 Citations (Scopus)586 Downloads (Pure) -
2013
Interactions between voltage sensor and pore domains in a hERG K(+) channel model from molecular simulations, and the effects of a voltage sensor mutation
Colenso, C. K., Sessions, R. B., Zhang, Y. H., Hancox, J. & Dempsey, C. E., 14 May 2013, In: Journal of Chemical Information and Modeling. 53, p. 1358-1370 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
21 Citations (Scopus) -
2012
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel
El Harchi, A., Melgari, D., Zhang, Y. H., Zhang, H. & Hancox, J. C., 2012, In: PLoS ONE. 7, 12, p. e52451Research output: Contribution to journal › Article (Academic Journal) › peer-review
22 Citations (Scopus) -
High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943
Cheng, H., Zhang, Y., Du, C., Dempsey, C. & Hancox, J., Apr 2012, In: British Journal of Pharmacology. 165, 7, p. 2260 - 2273 14 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
19 Citations (Scopus) -
Molecular determinants of hERG potassium channel inhibition by disopyramide
El Harchi, A., Zhang, Y., Hussein, L., Dempsey, C. & Hancox, J., Jan 2012, In: Journal of Molecular and Cellular Cardiology. 52, 1, p. 185 - 195 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
30 Citations (Scopus) -
2011
Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis
Du, C., El Harchi, A., Zhang, Y., Orchard, C. & Hancox, J., 2011, In: Journal of Cardiovascular Electrophysiology. p. in pressResearch output: Contribution to journal › Article (Academic Journal) › peer-review
35 Citations (Scopus) -
The hERG K(+) channel S4 domain L532P mutation: Characterization at 37°C
Zhang, Y., Colenso, C., Sessions, R., Dempsey, C. & Hancox, J., Oct 2011, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (10), p. 2477 - 2487Research output: Contribution to journal › Article (Academic Journal) › peer-review
35 Citations (Scopus) -
2010
Acidosis Impairs the Protective Role of hERG K(+) Channels Against Premature Stimulation
Du, C., Adeniran, I., Cheng, H., Zhang, Y., El Harchi, A., McPate, M., Zhang, H., Orchard, C. & Hancox, J., 2010, In: Journal of Cardiovascular Electrophysiology. 21, p. 1160 - 1169Research output: Contribution to journal › Article (Academic Journal) › peer-review
26 Citations (Scopus) -
Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation
El Harchi, A., McPate, M., Zhang, Y. & Hancox, J., 2010, In: Journal of Physiology and Pharmacology. 61, p. 123 - 131Research output: Contribution to journal › Article (Academic Journal) › peer-review
23 Citations (Scopus) -
Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone
Zhang, Y., Cheng, H., Alexeenko, V., Dempsey, C. & Hancox, J., 2010, In: Journal of Electrocardiology. 43, p. 440 - 448Research output: Contribution to journal › Article (Academic Journal) › peer-review
25 Citations (Scopus) -
2009
Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
El Harchi, A., McPate, M., Zhang, Y., Zhang, H. & Hancox, J., 2009, In: Journal of Molecular and Cellular Cardiology. 47, p. 743 - 747Research output: Contribution to journal › Article (Academic Journal) › peer-review
36 Citations (Scopus) -
2008
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
Hancox, J., McPate, M., El Harchi, A. & Zhang, Y., Aug 2008, In: Pharmacology and Therapeutics. 119, 2, p. 118 - 132 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
253 Citations (Scopus)