Projects per year
Neurones of the brain communicate with one another at specialised junctions, called synapses, through the process of synaptic transmission. Having hundreds or thousands of synapses on individual neurones provides for immense complexity in neuronal signalling. However, a further degree of complexity comes about because the communication between neurones is extremely plastic. This means that the strength of synaptic transmission is not fixed but can be increased or decreased (a process called synaptic plasticity) and this property of synaptic plasticity is one of the crucial processes that enables the brain to learn and to retain memories. Therefore, understanding how synaptic transmission occurs and how it can be regulated and modified is essential if we are to understand the workings of the central nervous system and to understand the processes of learning and memory.
Glutamate is the main transmitter at synapses in the brain and glutamate performs its functions by acting on a variety of different receptors; activation of each of these produces different effects at the synapse. The function of glutamate is also modified by other transmitters, such as acetylcholine. Teasing apart the different roles that these different receptors play and how these different receptors and transmitters interact with one another to produce synaptic plasticity is one of my main interests.
NMDA receptor subunit composition
One of the current projects in the lab is investigating how NMDA receptors differ in their subunit composition between different pathways (perforant path and Schaffer collaterals) that terminate onto CA1 pyramidal neurones in the hippocampus. We are interested in understanding whether differences in NMDA receptors confer different plastic properties on the synapses at the two input pathways to CA1 neurones
Mechanisms of plasticity and memory
To investigate synaptic transmission and plasticity we utilise a variety of in vitro techniques (molecular, electrophysiology, pharmacology) in the hippocampus, perirhinal and prefrontal cortex, depending on the precise questions. In collaboration with other groups we can then use this knowledge to investigate how mechanisms of plasticity are involved in learning and memory; see http://www.bristol.ac.uk/news/2008/212017945279.html for an example of how this multi-disciplinary approach works.
31/03/14 → 29/06/17
1/01/08 → 1/03/11
1/08/02 → 1/08/03
Using scalp EEG and intracranial EEG signals for predicting epileptic seizures: Review of available methodologiesUsman, S. M., Khalid, S., Akhtar, R., Bortolotto, Z., Bashir, Z. & Qiu, H., 1 Oct 2019, In: Seizure. 71, p. 258-269 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile10 Citations (Scopus)47 Downloads (Pure)
Pickford, J., Apps, R. & Bashir, Z., 16 Aug 2018, (E-pub ahead of print) In: Neurochemical Research. 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile248 Downloads (Pure)
Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal CortexSabec, M. H., Wonnacott, S., Warburton, E. C. & Bashir, Z. I., 27 Mar 2018, In: Cell Reports. 22, 13, p. 3409-3415 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile9 Citations (Scopus)237 Downloads (Pure)
Leverhulme Trust Senior Research Fellowship - The hippocampal-perirhinal-prefrontal cortex circuitry.
Zafar I Bashir (Recipient)1 Oct 2013 → 1 Oct 2014
Activity: Other activity types › Fellowship awarded competitively