Understanding the mechanisms underlying basic functions of the brain, such as synaptic transmission and plasticity. These represent fundamental functions and abilities of the brain that affect its output activities. These also forms the molecular basis of the brain activity which are involved in neurological conditions affecting learning and memory and/or implicated in Alzheimer's disease and epilepsy. We are investigating the roles different receptor systems in the control of synaptic plasticity and epileptiform activity in the hippocampus.