Project Details
Description
Developing novel biocompatible and antimicrobial coatings for orthopaedic implants
This multidisciplinary study is aimed at tackling the problem of antimicrobial resistance by developing 'smart' coatings for orthopaedic implants that promotes biointegration and are capable of eliminating bacterial infections before, during and long after implementation.
Up to 18 million hip and knee arthroplasties take place worldwide each year, with an estimated 100 million procedures undertaken for orthopaedic fixation and dental implants. Bacterial infections (commonly caused by Staphylococcus aureus) leading to orthopaedic implant failure occur in around 5% of cases, resulting in many millions of implants requiring revision due to infections each year.
Arthroplasty revision for infection usually involves two operations, separated by a course of local and systemic antibiotic for up to 3 months.
This project is aimed at developing a novel photocatalytic titanium dioxide (TiO2) based antimicrobial surface for use in orthopaedic implants capable of in situ decontamination without the need for revision surgery or the use of antibiotics which reduces antibiotic prescribing and the risk of developing antibiotic resistant strains of S. aureus.
This multidisciplinary study is aimed at tackling the problem of antimicrobial resistance by developing 'smart' coatings for orthopaedic implants that promotes biointegration and are capable of eliminating bacterial infections before, during and long after implementation.
Up to 18 million hip and knee arthroplasties take place worldwide each year, with an estimated 100 million procedures undertaken for orthopaedic fixation and dental implants. Bacterial infections (commonly caused by Staphylococcus aureus) leading to orthopaedic implant failure occur in around 5% of cases, resulting in many millions of implants requiring revision due to infections each year.
Arthroplasty revision for infection usually involves two operations, separated by a course of local and systemic antibiotic for up to 3 months.
This project is aimed at developing a novel photocatalytic titanium dioxide (TiO2) based antimicrobial surface for use in orthopaedic implants capable of in situ decontamination without the need for revision surgery or the use of antibiotics which reduces antibiotic prescribing and the risk of developing antibiotic resistant strains of S. aureus.
| Status | Active |
|---|---|
| Effective start/end date | 1/08/16 → … |
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