Project Details
Description
Background
The incidence of head and neck cancer (HNC) is predicted to increase by 30% (over 1 million new cases annually) by 2030. Global five-year survival rates for HNC are known to average at 50%, but the availability of survival data beyond five years from deeply phenotyped longitudinal studies is limited. There is a lack of consensus on what constitutes good or poor long-term outcomes and consequently the determinants of such outcomes are unknown. The late effects of cancer treatment is an underserved research topic. It is difficult to provide patients with meaningful information about survival, disease recurrence, or physical side effects of treatment in the long term.
Aims
To describe, at 10-year follow-up, the late effects - including the frequency and severity of secondary physical morbidities - of treatment for head and neck cancer among 5511 participants of an NIHR-funded clinical cohort study of head and neck cancer.
To identify factors at baseline, 12 months, and 3 years that may determine survival and/or further cancer presentation in human papillomavirus-positive and negative cases at 10-years.
Methods
Using a questionnaire, we will follow up participants in the NIHR Head and Neck 5000 (HN5000) study at 10 years. We will assess the frequency and severity of secondary physical effects of cancer treatment 10 years after diagnosis. We will investigate whether factors measured at diagnosis, such as genetics, treatment modality, lifestyle factors and comorbidity can predict or influence these secondary physical effects. We will follow-up the whole HN5000 cohort, linking to available data held by NHS Digital, to identify further cancer diagnoses, date and cause of death and further health problems. We will identify if factors at baseline, 12 months, and 3 years determine survival and/or further cancer presentation at 10-years.
How the results of this research will be used.
This study will provide information about long term outcomes of treatment for HNC that is currently unavailable and/or poorly understood. The results will inform the development of interventions to improve long-term outcomes, and provide real world data to better educate patients about their long-term prognoses. The outputs will be published in peer-reviewed journals, presented at relevant scientific conferences and will have the potential to inform future policy and practice (e.g., via the UK Multidisciplinary Head and Neck Cancer
guidelines).
The incidence of head and neck cancer (HNC) is predicted to increase by 30% (over 1 million new cases annually) by 2030. Global five-year survival rates for HNC are known to average at 50%, but the availability of survival data beyond five years from deeply phenotyped longitudinal studies is limited. There is a lack of consensus on what constitutes good or poor long-term outcomes and consequently the determinants of such outcomes are unknown. The late effects of cancer treatment is an underserved research topic. It is difficult to provide patients with meaningful information about survival, disease recurrence, or physical side effects of treatment in the long term.
Aims
To describe, at 10-year follow-up, the late effects - including the frequency and severity of secondary physical morbidities - of treatment for head and neck cancer among 5511 participants of an NIHR-funded clinical cohort study of head and neck cancer.
To identify factors at baseline, 12 months, and 3 years that may determine survival and/or further cancer presentation in human papillomavirus-positive and negative cases at 10-years.
Methods
Using a questionnaire, we will follow up participants in the NIHR Head and Neck 5000 (HN5000) study at 10 years. We will assess the frequency and severity of secondary physical effects of cancer treatment 10 years after diagnosis. We will investigate whether factors measured at diagnosis, such as genetics, treatment modality, lifestyle factors and comorbidity can predict or influence these secondary physical effects. We will follow-up the whole HN5000 cohort, linking to available data held by NHS Digital, to identify further cancer diagnoses, date and cause of death and further health problems. We will identify if factors at baseline, 12 months, and 3 years determine survival and/or further cancer presentation at 10-years.
How the results of this research will be used.
This study will provide information about long term outcomes of treatment for HNC that is currently unavailable and/or poorly understood. The results will inform the development of interventions to improve long-term outcomes, and provide real world data to better educate patients about their long-term prognoses. The outputs will be published in peer-reviewed journals, presented at relevant scientific conferences and will have the potential to inform future policy and practice (e.g., via the UK Multidisciplinary Head and Neck Cancer
guidelines).
| Status | Active |
|---|---|
| Effective start/end date | 1/04/23 → 31/03/26 |
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