CELLULAR BASIS OF ALBUMINURIA

Research output

Research output per year 2010 2011 2012 2013 2023

• 36 Article (Academic Journal)

Research output per year

Research output per year

Search results

• 2023

  A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome

  Kuzmuk, V., Pranke, I., Rollason, R., Butler, M., Ding, W. Y., Beesley, M., Waters, A. M., Coward, R. J., Sessions, R., Tuffin, J., Foster, R. R., Mollet, G., Antignac, C., Edelman, A., Welsh, G. I. & Saleem, M. A., 22 Nov 2023, (E-pub ahead of print) In: Kidney International.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Protein Misfolding Disorder 100%

  7 Citations (Scopus)

• 2013

  Glycosaminoglycan Regulation by VEGFA and VEGFC of the Glomerular Microvascular Endothelial Cell Glycocalyx in Vitro

  Foster, R. R., Armstrong, L., Baker, S., Wong, D. W. L., Wylie, E. C., Ramnath, R., Jenkins, R., Singh, A., Steadman, R., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., Aug 2013, In: American Journal of Pathology. 183, 2, p. 604-16 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycocalyx 100%
  • Restylane 100%
  • Glycosaminoglycan 100%
  • Chondroitin Sulfate 100%
  • Electric Resistance 33%

  49 Citations (Scopus)

• HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor

  Chandel, N., Sharma, B., Husain, M., Salhan, D., Singh, T., Rai, P., Mathieson, P. W., Saleem, M. A., Malhotra, A. & Singhal, P. C., 1 Jun 2013, In: American Journal of Physiology - Renal Physiology. 304, 11, p. F1347-57

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Downregulation 100%
  • Actin 100%
  • Cytoskeleton 100%
  • Human Immunodeficiency Virus 100%
  • Podocyte 100%

  31 Citations (Scopus)

• Insulin Directly Stimulates VEGF-A production in the Glomerular Podocyte

  Hale, L. J., Hurcombe, J., Lay, A. C., Santamaría, B., Valverde, A. M., Saleem, M. A., Mathieson, P. W., Welsh, G. I. & Coward, R. J. M., 22 May 2013, In: American Journal of Physiology - Renal Physiology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Vascular Endothelial Growth Factor A 100%
  • Insulin 100%
  • Insulin Receptor 25%
  • Wild Type 8%

  66 Citations (Scopus)

• Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse

  Hale, L. J., Welsh, G. I., Perks, C. M., Hurcombe, J. A., Moore, S. F., Hers, I., Saleem, M., Mathieson, P. W., Murphy, A., Jeansson, M., Holly, J. M. P., Hardouin, S. & Coward, R. J. M., May 2013, In: Journal of Pathology. 230, 1, p. 95-106 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Survival Factor 100%
  • Somatomedin B 100%
  • Mouse 100%
  • Insulin-Like Growth Factor 2 100%

  28 Citations (Scopus)

• Morphine induces albuminuria by compromising podocyte integrity

  Lan, X., Rai, P., Chandel, N., Cheng, K., Lederman, R., Saleem, M. A., Mathieson, P. W., Husain, M., Crosson, J. T., Gupta, K., Malhotra, A. & Singhal, P. C., 2013, In: PLOS ONE. 8, 3, p. e55748

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Albuminuria 100%
  • Morphine 100%
  • Podocyte 100%
  • In Vitro Study 30%
  • Glomerular Filtration Barrier 30%

  40 Citations (Scopus)

• mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN

  Rai, P., Plagov, A., Lan, X., Chandel, N., Singh, T., Lederman, R., Ayasolla, K. R., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A., Chander, P. N. & Singhal, P. C., 1 Aug 2013, In: American Journal of Physiology - Renal Physiology. 305, 3, p. F343-54

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • AIDS-Associated Nephropathy 100%

  21 Citations (Scopus)

• Nef interaction with actin compromises human podocyte actin cytoskeletal integrity

  Tan, R., Patni, H., Tandon, P., Luan, L., Sharma, B., Salhan, D., Saleem, M. A., Mathieson, P. W., Malhotra, A., Husain, M., Upadhya, P. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 51-7 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Actin 100%
  • Podocyte 100%
  • Human Immunodeficiency Virus 1 25%
  • Stable Cell 25%
  • Zyxin 25%

  26 Citations (Scopus)

• Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN

  Rai, P., Plagov, A., Kumar, D., Pathak, S., Ayasolla, K. R., Chawla, A. K., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 255-61 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Sirolimus 100%
  • Genetic Transcription 100%
  • Human Immunodeficiency Virus 100%
  • HIV 100%
  • HIV Associated Nephropathy 100%

  18 Citations (Scopus)

• Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN)

  Cheng, K., Rai, P., Plagov, A., Lan, X., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., 1 Aug 2013, In: Experimental Cell Research. 319, 13, p. 2073-80 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • MicroRNA 100%
  • Human Immunodeficiency Virus 100%
  • Sirolimus 100%
  • Human Immunodeficiency Virus 1 28%
  • Podocyte 28%

  12 Citations (Scopus)

• Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx

  Singh, A., Ramnath, R. D., Foster, R. R., Wylie, E. C., Fridén, V., Dasgupta, I., Haraldsson, B., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., 2013, In: PLOS ONE. 8, 2, p. e55852

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycocalyx 100%
  • Dioxygen 100%
  • Reactive Oxygen Metabolite 100%
  • Endothelial Cells 77%
  • Glycosaminoglycan 66%

  149 Citations (Scopus)

• Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes

  Ishimoto, T., Cara-Fuentes, G., Wang, H., Shimada, M., Wasserfall, C. H., Winter, W. E., Rivard, C. J., Araya, C. E., Saleem, M. A., Mathieson, P. W., Johnson, R. J. & Garin, E. H., Sept 2013, In: Pediatric Nephrology. 28, 9, p. 1803-12 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • CD80 100%
  • Minimal Change Disease 62%
  • Peripheral Blood Mononuclear Cell 50%
  • Cell Culture 25%

  38 Citations (Scopus)

• 2012

  A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

  Roumenina, L. T., Frimat, M., Miller, E. C., Provot, F., Dragon-Durey, M.-A., Bordereau, P., Bigot, S., Hue, C., Satchell, S. C., Mathieson, P. W., Mousson, C., Noel, C., Sautes-Fridman, C., Halbwachs-Mecarelli, L., Atkinson, J. P., Lionet, A. & Fremeaux-Bacchi, V., 3 May 2012, In: Blood. 119, 18, p. 4182-91 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • C3-Convertase 100%
  • CD46 100%
  • Factor H 75%
  • Haplotype 50%
  • Genetic Divergence 25%

  126 Citations (Scopus)

• Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes

  Slater, S. C., Ramnath, R. D., Uttridge, K., Saleem, M. A., Cahill, P. A., Mathieson, P. W., Welsh, G. I. & Satchell, S. C., 2012, In: International Journal of Biochemistry and Cell Biology. 44, 9, p. 1482-90 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Shear Stress 100%
  • Kruppel Like Factor 2 100%
  • Long Term Exposure 100%
  • Phosphotransferase 40%

  52 Citations (Scopus)

• Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) mutants lose the ability to activate transcription by nuclear hormone receptors

  Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, Y., Zhao, X., Saleem, M., Mathieson, P., Bruggerman, L. & Kao, H., Feb 2012, In: Journal of Biological Chemistry.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Transcription 100%
  • Nuclear Hormone Receptor 100%
  • Actinin 100%
  • Focal Segmental Glomerulosclerosis 100%
  • Transactivation 33%

  44 Citations (Scopus)

• Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4

  Hamer, R., Molostvov, G., Lowe, D., Satchell, S., Mathieson, P., Ilyas, R., Mitchell, D. A., Lam, F. T., Kashi, H., Tan, L. C., Imray, C., Fletcher, S., Briggs, D., Krishnan, N., Higgins, R. & Zehnder, D., 15 May 2012, In: Transplantation. 93, 9, p. 867-73 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Gamma Interferon 100%
  • Endothelial Cell 100%
  • Human Leukocyte Antigen 100%
  • Complement Factor 100%
  • Endothelium 100%

  17 Citations (Scopus)

• IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

  Rigothier, C., Auguste, P., Welsh, G. I., Lepreux, S., Deminière, C., Mathieson, P. W., Saleem, M. A., Ripoche, J. & Combe, C., 2012, In: PLOS ONE. 7, 5, p. e37695

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • IQGAP1 100%
  • Podocyte 100%
  • Cytoskeletal Proteins 25%
  • Immunoprecipitation 16%
  • Cytoskeleton 16%

  38 Citations (Scopus)

• Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells

  Prabakaran, T., Nielsen, R., Satchell, S. C., Mathieson, P. W., Feldt-Rasmussen, U., Sørensen, S. S. & Christensen, E. I., 2012, In: PLOS ONE. 7, 6, p. e39975

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Galactose 100%
  • Sortilin 100%
  • Somatomedin B Receptor 100%
  • Galactosidase 100%
  • Receptor 44%

  30 Citations (Scopus)

• MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation

  Asgeirsdóttir, S. A., van Solingen, C., Kurniati, N. F., Zwiers, P. J., Heeringa, P., van Meurs, M., Satchell, S. C., Saleem, M. A., Mathieson, P. W., Banas, B., Kamps, J. A. A. M., Rabelink, T. J., van Zonneveld, A. J. & Molema, G., 15 Jun 2012, In: American Journal of Physiology - Renal Physiology. 302, 12, p. F1630-9

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Protein Expression 100%
  • Serositis 100%
  • microRNA 126 100%
  • Vascular Cell Adhesion Molecule 1 100%
  • Acute Inflammation 100%

  105 Citations (Scopus)

• Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse

  Tanabe, K., Lanaspa, M. A., Kitagawa, W., Rivard, C. J., Miyazaki, M., Klawitter, J., Schreiner, G. F., Saleem, M. A., Mathieson, P. W., Makino, H., Johnson, R. J. & Nakagawa, T., 1 May 2012, In: American Journal of Physiology - Renal Physiology. 302, 9, p. F1151-F1160 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Diabetic Nephropathy 100%
  • Nicorandil 100%
  • Knockout Mouse 18%
  • Potassium Channel 18%
  • Adenosine Triphosphate 18%

  49 Citations (Scopus)

• Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

  Vashistha, H., Singhal, P. C., Malhotra, A., Husain, M., Mathieson, P., Saleem, M. A., Kuriakose, C., Seshan, S., Wilk, A., Delvalle, L., Peruzzi, F., Giorgio, M., Pelicci, P. G., Smithies, O., Kim, H.-S., Kakoki, M., Reiss, K. & Meggs, L. G., 15 Dec 2012, In: American Journal of Physiology - Renal Physiology. 303, 12, p. F1629-40

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Bradykinin Receptor B2 100%
  • Akita Mouse 100%
  • P53 75%
  • Oxidative Stress 50%
  • Programmed Cell Death 50%

  12 Citations (Scopus)

• Podocyte culture: tricks of the trade

  Ni, L., Saleem, M. & Mathieson, P. W., Aug 2012, In: Nephrology. 17, 6, p. 525-31 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Diseases 20%
  • In Vitro 20%

  90 Citations (Scopus)

• 2011

  Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia

  Zhao, S., Gu, Y., Coates, G., Groome, L., Saleem, M., Mathieson, P. & Wang, Y., Aug 2011, In: Reproductive Sciences. 18(8), p. 772 - 780 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Pre-Eclampsia 80%

  25 Citations (Scopus)

• Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

  Hu, N., Westra, J., Rutgers, A., Doornbos-Van der Meer, B., Huitema, M. G., Stegeman, C. A., Abdulahad, W. H., Satchell, S. C., Mathieson, P. W., Heeringa, P. & Kallenberg, C. G. M., Dec 2011, In: Arthritis Research and Therapy. 13, 6, p. R201 1 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Autoantibodies 100%
  • Neutrophil 100%
  • Vasculitis 100%
  • ANCA Associated Vasculitis 22%
  • Interleukin 8 16%

  43 Citations (Scopus)

• Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

  van der Veen, B., Chen, M., Muller, R., van Timmeren, M., Petersen, A., Lee, P., Satchell, S., Mathieson, P., Saleem, M., Stegeman, C., Zwerina, J., Molema, G. & Heeringa, P., Feb 2011, In: Annals of the Rheumatic Diseases. 70(2), p. 356 - 365 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  39 Citations (Scopus)

• Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy

  Sanchez-Nino, M., Sanz, A., Carrasco, S., Saleem, M., Mathieson, P., Valdivielso, J., Ruiz-Ortega, M., Egido, J. & Ortiz, A., Jun 2011, In: Nephrology Dialysis Transplantation. 26(6), p. 1797 - 1802 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  178 Citations (Scopus)

• Monocyte- and Endothelial-Derived Microparticles Induce an Inflammatory Phenotype in Human Podocytes

  Eyre, J., Burton, J., Saleem, M., Mathieson, P., Topham, P. & Brunskill, N., Aug 2011, In: Nephron Experimental Nephrology. 18;119(3), p. e58 - e66 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Monocyte 100%
  • Podocyte 100%
  • Mediator 20%
  • Secretion (Process) 20%
  • Endocytosis 20%

  48 Citations (Scopus)

• Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

  O'Flynn, J., Flierman, R., van der Pol, P., Rops, A., Satchell, S., Mathieson, P., van Kooten, C., van der Vlag, J., Berden, J. & Daha, M., Aug 2011, In: Molecular Immunology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Autoantibodies 100%
  • Nucleosome 100%
  • Complement Component C1q 100%
  • Complement Activation 100%
  • Endothelial Cells 100%

  28 Citations (Scopus)

• Phenotypic expression of ADAMTS13 in glomerular endothelial cells

  Tati, R., Kristoffersson, A., Stahl, A., Morgelin, M., Motto, D., Satchell, S., Mathieson, P., Manea-Hedstrom, M. & Karpman, D., 24 Jun 2011, In: PLOS ONE. 6, 6, 11 p., e21587.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • mice 35%
  • shear stress 11%
  • ultrastructure 10%
  • Skin 7%

  22 Citations (Scopus)

  350 Downloads (Pure)

• The podocyte as a target for therapies-new and old

  Mathieson, P., Nov 2011, In: Nature Reviews Nephrology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Kidney Disease 100%
  • Drug Development 50%
  • Glucocorticoid 50%
  • Adverse Event 50%
  • Actin 50%

  136 Citations (Scopus)

• Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-{kappa}B-dependent pathway

  Shimada, M., Ishimoto, T., Lee, P., Lanaspa, M., Rivard, C., Roncal-Jimenez, C., Wymer, D., Yarnabe, H., Mathieson, P., Saleem, M., Garin, E. & Johnson, R., May 2011, In: Nephrology Dialysis Transplantation.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  91 Citations (Scopus)

• 2010

  DC-specific ICAM-3-grabbing nonintegrin mediates internalization of HIV-1 into human podocytes

  Mikulak, J., Teichberg, S., Arora, S., kumar, D., Kumar, D., Yadav, A., Salhan, D., Pullagura, S., Mathieson, P., Saleem, M. & Singhal, P., Sept 2010, In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 299(3), p. F664 - F673 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Human Immunodeficiency Virus 1 100%
  • Internalization 100%
  • Podocyte 100%
  • DC-SIGN 100%
  • Genetic Transfection 20%

  25 Citations (Scopus)

• Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

  Summers, S., van der Veen, B., O'Sullivan, K., Gan, P., Ooi, J., Heeringa, P., Satchell, S., Mathieson, P., Saleem, M., Visvanathan, K., Holdsworth, S. & Kitching, A., Dec 2010, In: Kidney International. 78(12), p. 1263 - 1274 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • TLR4 100%
  • Neutrophil 100%
  • Leukocyte 100%
  • Glomerulonephritis 100%
  • Endothelial Cells 50%

  60 Citations (Scopus)

• PDGF-C Mediates Glomerular Capillary Repair

  Boor, P., van Roeyen, C., Kunter, U., Villa, L., Bucher, E., Hohenstein, B., Hugo, C., Eriksson, U., Satchell, S., Mathieson, P., Eitner, F. & Ostendorf, T., Jul 2010, In: American Journal of Pathology. 177(1), p. 58 - 69 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerular Capillary 100%
  • Platelet Derived Growth Factor C 100%
  • Endothelial Cell 72%
  • Infusion 27%
  • Thrombotic Thrombocytopenic Purpura 27%

  36 Citations (Scopus)

• Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product

  Matsumoto, T., Hess, S., Kajiyama, H., Sakairi, T., Saleem, M., Mathieson, P., Nojima, Y. & Kopp, J., Oct 2010, In: AJP - Renal Physiology. 299(4), p. F776 - F784 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Insulin-Like Growth Factor-Binding Protein 100%
  • Podocyte 100%
  • Synapsin I 100%
  • Proteomics 100%
  • Proteome 40%

  15 Citations (Scopus)

• Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study

  Asgeirsdottir, S., Talman, E., de Graaf, I., Kamps, J., Satchell, S., Mathieson, P., Ruiters, M. & Molema, G., Jan 2010, In: Journal of Controlled Release. 25;141(2), p. 241 - 251 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • In Vitro Techniques 13%

  35 Citations (Scopus)