CELLULAR BASIS OF ALBUMINURIA

2023

A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome

Kuzmuk, V., Pranke, I., Rollason, R., Butler, M., Ding, W. Y., Beesley, M., Waters, A. M., Coward, R. J., Sessions, R., Tuffin, J., Foster, R. R., Mollet, G., Antignac, C., Edelman, A., Welsh, G. I. & Saleem, M. A., 22 Nov 2023, (E-pub ahead of print) In: Kidney International.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

6 Citations (Scopus)

2013

Glycosaminoglycan Regulation by VEGFA and VEGFC of the Glomerular Microvascular Endothelial Cell Glycocalyx in Vitro

Foster, R. R., Armstrong, L., Baker, S., Wong, D. W. L., Wylie, E. C., Ramnath, R., Jenkins, R., Singh, A., Steadman, R., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., Aug 2013, In: American Journal of Pathology. 183, 2, p. 604-16 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

49 Citations (Scopus)

HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor

Chandel, N., Sharma, B., Husain, M., Salhan, D., Singh, T., Rai, P., Mathieson, P. W., Saleem, M. A., Malhotra, A. & Singhal, P. C., 1 Jun 2013, In: AJP - Renal Physiology. 304, 11, p. F1347-57

Research output: Contribution to journal › Article (Academic Journal) › peer-review

31 Citations (Scopus)

Insulin Directly Stimulates VEGF-A production in the Glomerular Podocyte

Hale, L. J., Hurcombe, J., Lay, A. C., Santamaría, B., Valverde, A. M., Saleem, M. A., Mathieson, P. W., Welsh, G. I. & Coward, R. J. M., 22 May 2013, In: AJP - Renal Physiology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse

Hale, L. J., Welsh, G. I., Perks, C. M., Hurcombe, J. A., Moore, S. F., Hers, I., Saleem, M., Mathieson, P. W., Murphy, A., Jeansson, M., Holly, J. M. P., Hardouin, S. & Coward, R. J. M., May 2013, In: Journal of Pathology. 230, 1, p. 95-106 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

28 Citations (Scopus)

Morphine induces albuminuria by compromising podocyte integrity

Lan, X., Rai, P., Chandel, N., Cheng, K., Lederman, R., Saleem, M. A., Mathieson, P. W., Husain, M., Crosson, J. T., Gupta, K., Malhotra, A. & Singhal, P. C., 2013, In: PLOS ONE. 8, 3, p. e55748

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN

Rai, P., Plagov, A., Lan, X., Chandel, N., Singh, T., Lederman, R., Ayasolla, K. R., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A., Chander, P. N. & Singhal, P. C., 1 Aug 2013, In: AJP - Renal Physiology. 305, 3, p. F343-54

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

Nef interaction with actin compromises human podocyte actin cytoskeletal integrity

Tan, R., Patni, H., Tandon, P., Luan, L., Sharma, B., Salhan, D., Saleem, M. A., Mathieson, P. W., Malhotra, A., Husain, M., Upadhya, P. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 51-7 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

25 Citations (Scopus)

Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN

Rai, P., Plagov, A., Kumar, D., Pathak, S., Ayasolla, K. R., Chawla, A. K., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 255-61 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

18 Citations (Scopus)

Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN)

Cheng, K., Rai, P., Plagov, A., Lan, X., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., 1 Aug 2013, In: Experimental Cell Research. 319, 13, p. 2073-80 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx

Singh, A., Ramnath, R. D., Foster, R. R., Wylie, E. C., Fridén, V., Dasgupta, I., Haraldsson, B., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., 2013, In: PLOS ONE. 8, 2, p. e55852

Research output: Contribution to journal › Article (Academic Journal) › peer-review

144 Citations (Scopus)

Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes

Ishimoto, T., Cara-Fuentes, G., Wang, H., Shimada, M., Wasserfall, C. H., Winter, W. E., Rivard, C. J., Araya, C. E., Saleem, M. A., Mathieson, P. W., Johnson, R. J. & Garin, E. H., Sept 2013, In: Pediatric Nephrology. 28, 9, p. 1803-12 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

2012

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

Roumenina, L. T., Frimat, M., Miller, E. C., Provot, F., Dragon-Durey, M.-A., Bordereau, P., Bigot, S., Hue, C., Satchell, S. C., Mathieson, P. W., Mousson, C., Noel, C., Sautes-Fridman, C., Halbwachs-Mecarelli, L., Atkinson, J. P., Lionet, A. & Fremeaux-Bacchi, V., 3 May 2012, In: Blood. 119, 18, p. 4182-91 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

123 Citations (Scopus)

Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes

Slater, S. C., Ramnath, R. D., Uttridge, K., Saleem, M. A., Cahill, P. A., Mathieson, P. W., Welsh, G. I. & Satchell, S. C., 2012, In: International Journal of Biochemistry and Cell Biology. 44, 9, p. 1482-90 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

48 Citations (Scopus)

Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) mutants lose the ability to activate transcription by nuclear hormone receptors

Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, Y., Zhao, X., Saleem, M., Mathieson, P., Bruggerman, L. & Kao, H., Feb 2012, In: Journal of Biological Chemistry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

43 Citations (Scopus)

Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4

Hamer, R., Molostvov, G., Lowe, D., Satchell, S., Mathieson, P., Ilyas, R., Mitchell, D. A., Lam, F. T., Kashi, H., Tan, L. C., Imray, C., Fletcher, S., Briggs, D., Krishnan, N., Higgins, R. & Zehnder, D., 15 May 2012, In: Transplantation. 93, 9, p. 867-73 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

17 Citations (Scopus)

IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

Rigothier, C., Auguste, P., Welsh, G. I., Lepreux, S., Deminière, C., Mathieson, P. W., Saleem, M. A., Ripoche, J. & Combe, C., 2012, In: PLOS ONE. 7, 5, p. e37695

Research output: Contribution to journal › Article (Academic Journal) › peer-review

36 Citations (Scopus)

Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells

Prabakaran, T., Nielsen, R., Satchell, S. C., Mathieson, P. W., Feldt-Rasmussen, U., Sørensen, S. S. & Christensen, E. I., 2012, In: PLOS ONE. 7, 6, p. e39975

Research output: Contribution to journal › Article (Academic Journal) › peer-review

29 Citations (Scopus)

MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation

Asgeirsdóttir, S. A., van Solingen, C., Kurniati, N. F., Zwiers, P. J., Heeringa, P., van Meurs, M., Satchell, S. C., Saleem, M. A., Mathieson, P. W., Banas, B., Kamps, J. A. A. M., Rabelink, T. J., van Zonneveld, A. J. & Molema, G., 15 Jun 2012, In: AJP - Renal Physiology. 302, 12, p. F1630-9

Research output: Contribution to journal › Article (Academic Journal) › peer-review

103 Citations (Scopus)

Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse

Tanabe, K., Lanaspa, M. A., Kitagawa, W., Rivard, C. J., Miyazaki, M., Klawitter, J., Schreiner, G. F., Saleem, M. A., Mathieson, P. W., Makino, H., Johnson, R. J. & Nakagawa, T., 1 May 2012, In: AJP - Renal Physiology. 302, 9, p. F1151-F1160 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

48 Citations (Scopus)

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

Vashistha, H., Singhal, P. C., Malhotra, A., Husain, M., Mathieson, P., Saleem, M. A., Kuriakose, C., Seshan, S., Wilk, A., Delvalle, L., Peruzzi, F., Giorgio, M., Pelicci, P. G., Smithies, O., Kim, H.-S., Kakoki, M., Reiss, K. & Meggs, L. G., 15 Dec 2012, In: AJP - Renal Physiology. 303, 12, p. F1629-40

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Podocyte culture: tricks of the trade

Ni, L., Saleem, M. & Mathieson, P. W., Aug 2012, In: Nephrology. 17, 6, p. 525-31 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

86 Citations (Scopus)

2011

Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia

Zhao, S., Gu, Y., Coates, G., Groome, L., Saleem, M., Mathieson, P. & Wang, Y., Aug 2011, In: Reproductive Sciences. 18(8), p. 772 - 780 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

25 Citations (Scopus)

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

Hu, N., Westra, J., Rutgers, A., Doornbos-Van der Meer, B., Huitema, M. G., Stegeman, C. A., Abdulahad, W. H., Satchell, S. C., Mathieson, P. W., Heeringa, P. & Kallenberg, C. G. M., Dec 2011, In: Arthritis Research and Therapy. 13, 6, p. R201 1 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

42 Citations (Scopus)

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

van der Veen, B., Chen, M., Muller, R., van Timmeren, M., Petersen, A., Lee, P., Satchell, S., Mathieson, P., Saleem, M., Stegeman, C., Zwerina, J., Molema, G. & Heeringa, P., Feb 2011, In: Annals of the Rheumatic Diseases. 70(2), p. 356 - 365 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy

Sanchez-Nino, M., Sanz, A., Carrasco, S., Saleem, M., Mathieson, P., Valdivielso, J., Ruiz-Ortega, M., Egido, J. & Ortiz, A., Jun 2011, In: Nephrology Dialysis Transplantation. 26(6), p. 1797 - 1802 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

173 Citations (Scopus)

Monocyte- and Endothelial-Derived Microparticles Induce an Inflammatory Phenotype in Human Podocytes

Eyre, J., Burton, J., Saleem, M., Mathieson, P., Topham, P. & Brunskill, N., Aug 2011, In: Nephron Experimental Nephrology. 18;119(3), p. e58 - e66 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

48 Citations (Scopus)

Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

O'Flynn, J., Flierman, R., van der Pol, P., Rops, A., Satchell, S., Mathieson, P., van Kooten, C., van der Vlag, J., Berden, J. & Daha, M., Aug 2011, In: Molecular Immunology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

27 Citations (Scopus)

Phenotypic expression of ADAMTS13 in glomerular endothelial cells

Tati, R., Kristoffersson, A., Stahl, A., Morgelin, M., Motto, D., Satchell, S., Mathieson, P., Manea-Hedstrom, M. & Karpman, D., 24 Jun 2011, In: PLOS ONE. 6, 6, 11 p., e21587.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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22 Citations (Scopus)

334 Downloads (Pure)

The podocyte as a target for therapies-new and old

Mathieson, P., Nov 2011, In: Nature Reviews Nephrology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

132 Citations (Scopus)

Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-{kappa}B-dependent pathway

Shimada, M., Ishimoto, T., Lee, P., Lanaspa, M., Rivard, C., Roncal-Jimenez, C., Wymer, D., Yarnabe, H., Mathieson, P., Saleem, M., Garin, E. & Johnson, R., May 2011, In: Nephrology Dialysis Transplantation.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

90 Citations (Scopus)

2010

DC-specific ICAM-3-grabbing nonintegrin mediates internalization of HIV-1 into human podocytes

Mikulak, J., Teichberg, S., Arora, S., kumar, D., Kumar, D., Yadav, A., Salhan, D., Pullagura, S., Mathieson, P., Saleem, M. & Singhal, P., Sept 2010, In: AJP - Renal Physiology. 299(3), p. F664 - F673 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

25 Citations (Scopus)

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

Summers, S., van der Veen, B., O'Sullivan, K., Gan, P., Ooi, J., Heeringa, P., Satchell, S., Mathieson, P., Saleem, M., Visvanathan, K., Holdsworth, S. & Kitching, A., Dec 2010, In: Kidney International. 78(12), p. 1263 - 1274 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

59 Citations (Scopus)

PDGF-C Mediates Glomerular Capillary Repair

Boor, P., van Roeyen, C., Kunter, U., Villa, L., Bucher, E., Hohenstein, B., Hugo, C., Eriksson, U., Satchell, S., Mathieson, P., Eitner, F. & Ostendorf, T., Jul 2010, In: American Journal of Pathology. 177(1), p. 58 - 69 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

36 Citations (Scopus)

Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product

Matsumoto, T., Hess, S., Kajiyama, H., Sakairi, T., Saleem, M., Mathieson, P., Nojima, Y. & Kopp, J., Oct 2010, In: AJP - Renal Physiology. 299(4), p. F776 - F784 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

15 Citations (Scopus)

Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study

Asgeirsdottir, S., Talman, E., de Graaf, I., Kamps, J., Satchell, S., Mathieson, P., Ruiters, M. & Molema, G., Jan 2010, In: Journal of Controlled Release. 25;141(2), p. 241 - 251 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

33 Citations (Scopus)

CELLULAR BASIS OF ALBUMINURIA

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2023

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2012

2011

2010