CELLULAR BASIS OF ALBUMINURIA

Research output

Research output per year 2010 2011 2012 2013 2023

• 36 Article (Academic Journal)

Research output per year

Research output per year

Search results

• 2023

  A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome

  Kuzmuk, V., Pranke, I., Rollason, R., Butler, M., Ding, W. Y., Beesley, M., Waters, A. M., Coward, R. J., Sessions, R., Tuffin, J., Foster, R. R., Mollet, G., Antignac, C., Edelman, A., Welsh, G. I. & Saleem, M. A., 22 Nov 2023, (E-pub ahead of print) In: Kidney International.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Genetics 100%
  • Small Molecule 100%
  • Podocin 100%
  • Keratin 8 100%
  • Cell Membrane 25%
  3 Citations (Scopus)
• 2013

  Glycosaminoglycan Regulation by VEGFA and VEGFC of the Glomerular Microvascular Endothelial Cell Glycocalyx in Vitro

  Foster, R. R., Armstrong, L., Baker, S., Wong, D. W. L., Wylie, E. C., Ramnath, R., Jenkins, R., Singh, A., Steadman, R., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., Aug 2013, In: American Journal of Pathology. 183, 2, p. 604-16 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endothelial Cells 100%
  • Glycocalyx 100%
  • Hyaluronic Acid 100%
  • Glycosaminoglycan 100%
  • Chondroitin Sulfate 100%
  46 Citations (Scopus)

• HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor

  Chandel, N., Sharma, B., Husain, M., Salhan, D., Singh, T., Rai, P., Mathieson, P. W., Saleem, M. A., Malhotra, A. & Singhal, P. C., 1 Jun 2013, In: AJP - Renal Physiology. 304, 11, p. F1347-57

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cytoskeleton 100%
  • Human Immunodeficiency Virus 100%
  • Actin 100%
  • Downregulation 100%
  • Podocyte 100%
  31 Citations (Scopus)

• Insulin Directly Stimulates VEGF-A production in the Glomerular Podocyte

  Hale, L. J., Hurcombe, J., Lay, A. C., Santamaría, B., Valverde, A. M., Saleem, M. A., Mathieson, P. W., Welsh, G. I. & Coward, R. J. M., 22 May 2013, In: AJP - Renal Physiology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Vascular Endothelial Growth Factor A 100%
  • Insulin Receptor 25%
  • Mouse 16%
  • Wild Type 8%
  63 Citations (Scopus)

• Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse

  Hale, L. J., Welsh, G. I., Perks, C. M., Hurcombe, J. A., Moore, S. F., Hers, I., Saleem, M., Mathieson, P. W., Murphy, A., Jeansson, M., Holly, J. M. P., Hardouin, S. & Coward, R. J. M., May 2013, In: Journal of Pathology. 230, 1, p. 95-106 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Somatomedin B 100%
  • Podocyte 100%
  • Survival Factor 100%
  • Insulin-Like Growth Factor 2 100%
  • In Vitro 25%
  24 Citations (Scopus)

• Morphine induces albuminuria by compromising podocyte integrity

  Lan, X., Rai, P., Chandel, N., Cheng, K., Lederman, R., Saleem, M. A., Mathieson, P. W., Husain, M., Crosson, J. T., Gupta, K., Malhotra, A. & Singhal, P. C., 2013, In: PLoS ONE. 8, 3, p. e55748

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Albuminuria 100%
  • Morphine 100%
  • Diaphragm 50%
  • In Vitro Study 30%
  33 Citations (Scopus)

• mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN

  Rai, P., Plagov, A., Lan, X., Chandel, N., Singh, T., Lederman, R., Ayasolla, K. R., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A., Chander, P. N. & Singhal, P. C., 1 Aug 2013, In: AJP - Renal Physiology. 305, 3, p. F343-54

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • AIDS-Associated Nephropathy 100%
  21 Citations (Scopus)

• Nef interaction with actin compromises human podocyte actin cytoskeletal integrity

  Tan, R., Patni, H., Tandon, P., Luan, L., Sharma, B., Salhan, D., Saleem, M. A., Mathieson, P. W., Malhotra, A., Husain, M., Upadhya, P. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 51-7 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Actin 100%
  • Podocyte 100%
  • Cell Line 28%
  • Human Immunodeficiency Virus 1 28%
  • Filopodia 28%
  25 Citations (Scopus)

• Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN

  Rai, P., Plagov, A., Kumar, D., Pathak, S., Ayasolla, K. R., Chawla, A. K., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 255-61 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Sirolimus 100%
  • Genetic Transcription 100%
  • Human Immunodeficiency Virus 100%
  • Human Immunodeficiency Virus 1 25%
  • Podocyte 25%
  17 Citations (Scopus)

• Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN)

  Cheng, K., Rai, P., Plagov, A., Lan, X., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., 1 Aug 2013, In: Experimental Cell Research. 319, 13, p. 2073-80 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Sirolimus 100%
  • Human Immunodeficiency Virus 100%
  • Human Immunodeficiency Virus 1 28%
  • Podocyte 28%
  • Upregulation 14%
  12 Citations (Scopus)

• Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx

  Singh, A., Ramnath, R. D., Foster, R. R., Wylie, E. C., Fridén, V., Dasgupta, I., Haraldsson, B., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., 2013, In: PLoS ONE. 8, 2, p. e55852

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycocalyx 100%
  • Reactive Oxygen Metabolite 100%
  • Proteinuria 100%
  • Glycosaminoglycan 66%
  • Glomerulopathy 50%
  133 Citations (Scopus)

• Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes

  Ishimoto, T., Cara-Fuentes, G., Wang, H., Shimada, M., Wasserfall, C. H., Winter, W. E., Rivard, C. J., Araya, C. E., Saleem, M. A., Mathieson, P. W., Johnson, R. J. & Garin, E. H., Sept 2013, In: Pediatric Nephrology. 28, 9, p. 1803-12 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • CD80 100%
  • Podocyte 100%
  • Peripheral Blood Mononuclear Cell 40%
  • Cell Culture 20%
  • Supernatant 20%
  36 Citations (Scopus)
• 2012

  A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

  Roumenina, L. T., Frimat, M., Miller, E. C., Provot, F., Dragon-Durey, M.-A., Bordereau, P., Bigot, S., Hue, C., Satchell, S. C., Mathieson, P. W., Mousson, C., Noel, C., Sautes-Fridman, C., Halbwachs-Mecarelli, L., Atkinson, J. P., Lionet, A. & Fremeaux-Bacchi, V., 3 May 2012, In: Blood. 119, 18, p. 4182-91 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Classical Complement Pathway C3 C5 Convertase 100%
  • Atypical Hemolytic Uremic Syndrome 100%
  • C3-Convertase 100%
  • CD46 100%
  • Membrane Cofactor Protein 80%
  120 Citations (Scopus)

• Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes

  Slater, S. C., Ramnath, R. D., Uttridge, K., Saleem, M. A., Cahill, P. A., Mathieson, P. W., Welsh, G. I. & Satchell, S. C., 2012, In: International Journal of Biochemistry and Cell Biology. 44, 9, p. 1482-90 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endothelial Cell 100%
  • Long Term Exposure 100%
  • Podocyte 100%
  • Kruppel Like Factor 2 100%
  • Shear Stress 100%
  48 Citations (Scopus)

• Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) mutants lose the ability to activate transcription by nuclear hormone receptors

  Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, Y., Zhao, X., Saleem, M., Mathieson, P., Bruggerman, L. & Kao, H., Feb 2012, In: Journal of Biological Chemistry.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Transcription 100%
  • Nuclear Hormone Receptor 100%
  • Actinin 100%
  • Focal Segmental Glomerulosclerosis 100%
  • Transactivation 33%
  40 Citations (Scopus)

• Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4

  Hamer, R., Molostvov, G., Lowe, D., Satchell, S., Mathieson, P., Ilyas, R., Mitchell, D. A., Lam, F. T., Kashi, H., Tan, L. C., Imray, C., Fletcher, S., Briggs, D., Krishnan, N., Higgins, R. & Zehnder, D., 15 May 2012, In: Transplantation. 93, 9, p. 867-73 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Gamma Interferon 100%
  • Endothelial Cell 100%
  • Human Leukocyte Antigen 100%
  • Complement Factor 100%
  • Antibodies 100%
  16 Citations (Scopus)

• IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

  Rigothier, C., Auguste, P., Welsh, G. I., Lepreux, S., Deminière, C., Mathieson, P. W., Saleem, M. A., Ripoche, J. & Combe, C., 2012, In: PLoS ONE. 7, 5, p. e37695

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • IQGAP1 100%
  • Podocyte 100%
  • Diaphragm 100%
  • Cytoskeletal Protein 25%
  • Proximity Ligation Assay 18%
  35 Citations (Scopus)

• Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells

  Prabakaran, T., Nielsen, R., Satchell, S. C., Mathieson, P. W., Feldt-Rasmussen, U., Sørensen, S. S. & Christensen, E. I., 2012, In: PLoS ONE. 7, 6, p. e39975

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endothelial Cell 100%
  • Somatomedin B Receptor 100%
  • Endocytosis 100%
  • Sortilin 100%
  • Galactose 100%
  28 Citations (Scopus)

• MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation

  Asgeirsdóttir, S. A., van Solingen, C., Kurniati, N. F., Zwiers, P. J., Heeringa, P., van Meurs, M., Satchell, S. C., Saleem, M. A., Mathieson, P. W., Banas, B., Kamps, J. A. A. M., Rabelink, T. J., van Zonneveld, A. J. & Molema, G., 15 Jun 2012, In: AJP - Renal Physiology. 302, 12, p. F1630-9

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Protein Expression 100%
  • Serositis 100%
  • microRNA 126 100%
  • Vascular Cell Adhesion Molecule 1 100%
  • Acute Inflammation 100%
  100 Citations (Scopus)

• Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse

  Tanabe, K., Lanaspa, M. A., Kitagawa, W., Rivard, C. J., Miyazaki, M., Klawitter, J., Schreiner, G. F., Saleem, M. A., Mathieson, P. W., Makino, H., Johnson, R. J. & Nakagawa, T., 1 May 2012, In: AJP - Renal Physiology. 302, 9, p. F1151-F1160 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Diabetic Nephropathy 100%
  • Nicorandil 100%
  • Knockout Mouse 18%
  • Potassium Channel 18%
  • Adenosine Triphosphate 18%
  47 Citations (Scopus)

• Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

  Vashistha, H., Singhal, P. C., Malhotra, A., Husain, M., Mathieson, P., Saleem, M. A., Kuriakose, C., Seshan, S., Wilk, A., Delvalle, L., Peruzzi, F., Giorgio, M., Pelicci, P. G., Smithies, O., Kim, H.-S., Kakoki, M., Reiss, K. & Meggs, L. G., 15 Dec 2012, In: AJP - Renal Physiology. 303, 12, p. F1629-40

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Bradykinin Receptor B2 100%
  • Akita Mouse 100%
  • P53 75%
  • Oxidative Stress 50%
  • Metabolic Pathway 25%
  11 Citations (Scopus)

• Podocyte culture: tricks of the trade

  Ni, L., Saleem, M. & Mathieson, P. W., Aug 2012, In: Nephrology. 17, 6, p. 525-31 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • In Vitro 20%
  • Nephropathy 20%
  • Injury 20%
  • Epithelial Cell 20%
  76 Citations (Scopus)
• 2011

  Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia

  Zhao, S., Gu, Y., Coates, G., Groome, L., Saleem, M., Mathieson, P. & Wang, Y., Aug 2011, In: Reproductive Sciences. 18(8), p. 772 - 780 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Pre-Eclampsia 80%
  25 Citations (Scopus)

• Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

  Hu, N., Westra, J., Rutgers, A., Doornbos-Van der Meer, B., Huitema, M. G., Stegeman, C. A., Abdulahad, W. H., Satchell, S. C., Mathieson, P. W., Heeringa, P. & Kallenberg, C. G. M., Dec 2011, In: Arthritis Research and Therapy. 13, 6, p. R201 1 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Autoantibodies 100%
  • Neutrophil Granulocyte 100%
  • Neutrophil 100%
  • Vasculitis 100%
  • ANCA Associated Vasculitis 44%
  40 Citations (Scopus)

• Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

  van der Veen, B., Chen, M., Muller, R., van Timmeren, M., Petersen, A., Lee, P., Satchell, S., Mathieson, P., Saleem, M., Stegeman, C., Zwerina, J., Molema, G. & Heeringa, P., Feb 2011, In: Annals of the Rheumatic Diseases. 70(2), p. 356 - 365 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  35 Citations (Scopus)

• Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy

  Sanchez-Nino, M., Sanz, A., Carrasco, S., Saleem, M., Mathieson, P., Valdivielso, J., Ruiz-Ortega, M., Egido, J. & Ortiz, A., Jun 2011, In: Nephrology Dialysis Transplantation. 26(6), p. 1797 - 1802 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  166 Citations (Scopus)

• Monocyte- and Endothelial-Derived Microparticles Induce an Inflammatory Phenotype in Human Podocytes

  Eyre, J., Burton, J., Saleem, M., Mathieson, P., Topham, P. & Brunskill, N., Aug 2011, In: Nephron Experimental Nephrology. 18;119(3), p. e58 - e66 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Microparticle 100%
  • Proteinuria 30%
  • Secretion (Process) 20%
  • Glomerulus Basement Membrane 20%
  48 Citations (Scopus)

• Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

  O'Flynn, J., Flierman, R., van der Pol, P., Rops, A., Satchell, S., Mathieson, P., van Kooten, C., van der Vlag, J., Berden, J. & Daha, M., Aug 2011, In: Molecular Immunology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Endothelial Cell 100%
  • Complement Activation 100%
  • Complement Component C1q 100%
  • Autoantibodies 100%
  • Nucleosome 100%
  26 Citations (Scopus)

• Phenotypic expression of ADAMTS13 in glomerular endothelial cells

  Tati, R., Kristoffersson, A., Stahl, A., Morgelin, M., Motto, D., Satchell, S., Mathieson, P., Manea-Hedstrom, M. & Karpman, D., 24 Jun 2011, In: PLoS ONE. 6, 6, 11 p., e21587.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • mice 35%
  • shear stress 11%
  • ultrastructure 10%
  • Skin 7%
  20 Citations (Scopus)

  324 Downloads (Pure)

• The podocyte as a target for therapies-new and old

  Mathieson, P., Nov 2011, In: Nature Reviews Nephrology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Injury 100%
  • Podocyte 100%
  • Kidney Disease 66%
  • Drug Development 33%
  • Glucocorticoid 33%
  128 Citations (Scopus)

• Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-{kappa}B-dependent pathway

  Shimada, M., Ishimoto, T., Lee, P., Lanaspa, M., Rivard, C., Roncal-Jimenez, C., Wymer, D., Yarnabe, H., Mathieson, P., Saleem, M., Garin, E. & Johnson, R., May 2011, In: Nephrology Dialysis Transplantation.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  84 Citations (Scopus)
• 2010

  DC-specific ICAM-3-grabbing nonintegrin mediates internalization of HIV-1 into human podocytes

  Mikulak, J., Teichberg, S., Arora, S., kumar, D., Kumar, D., Yadav, A., Salhan, D., Pullagura, S., Mathieson, P., Saleem, M. & Singhal, P., Sept 2010, In: AJP - Renal Physiology. 299(3), p. F664 - F673 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Human Immunodeficiency Virus 1 100%
  • Podocyte 100%
  • Internalization 100%
  • DC-SIGN 100%
  • Small Interfering RNA 30%
  25 Citations (Scopus)

• Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

  Summers, S., van der Veen, B., O'Sullivan, K., Gan, P., Ooi, J., Heeringa, P., Satchell, S., Mathieson, P., Saleem, M., Visvanathan, K., Holdsworth, S. & Kitching, A., Dec 2010, In: Kidney International. 78(12), p. 1263 - 1274 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Leukocyte 100%
  • Neutrophil 100%
  • Glomerulonephritis 100%
  • Toll Like Receptor 4 100%
  • Injury 66%
  55 Citations (Scopus)

• PDGF-C Mediates Glomerular Capillary Repair

  Boor, P., van Roeyen, C., Kunter, U., Villa, L., Bucher, E., Hohenstein, B., Hugo, C., Eriksson, U., Satchell, S., Mathieson, P., Eitner, F. & Ostendorf, T., Jul 2010, In: American Journal of Pathology. 177(1), p. 58 - 69 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerular Capillary 100%
  • Platelet Derived Growth Factor C 100%
  • Endothelial Cell 72%
  • Diseases 27%
  • Infusion 27%
  35 Citations (Scopus)

• Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product

  Matsumoto, T., Hess, S., Kajiyama, H., Sakairi, T., Saleem, M., Mathieson, P., Nojima, Y. & Kopp, J., Oct 2010, In: AJP - Renal Physiology. 299(4), p. F776 - F784 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Insulin-Like Growth Factor-Binding Protein 100%
  • Proteomics 100%
  • Podocyte 100%
  • Synapsin I 100%
  • Proteome 40%
  14 Citations (Scopus)

• Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study

  Asgeirsdottir, S., Talman, E., de Graaf, I., Kamps, J., Satchell, S., Mathieson, P., Ruiters, M. & Molema, G., Jan 2010, In: Journal of Controlled Release. 25;141(2), p. 241 - 251 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • In Vitro Techniques 13%
  33 Citations (Scopus)