CELLULAR BASIS OF ALBUMINURIA

Research output

Research output per year 2010 2011 2012 2013 2013

• 35 Article (Academic Journal)

Research output per year

Research output per year

Search results

• 2013

  Glycosaminoglycan Regulation by VEGFA and VEGFC of the Glomerular Microvascular Endothelial Cell Glycocalyx in Vitro

  Foster, R. R., Armstrong, L., Baker, S., Wong, D. W. L., Wylie, E. C., Ramnath, R., Jenkins, R., Singh, A., Steadman, R., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., Aug 2013, In: American Journal of Pathology. 183, 2, p. 604-16 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Chondroitin Sulfate 100%
  • Glycocalyx 66%
  • Glycosaminoglycan 50%
  • Shedding 50%
  • Synthesis 33%
  41 Citations (Scopus)

• HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor

  Chandel, N., Sharma, B., Husain, M., Salhan, D., Singh, T., Rai, P., Mathieson, P. W., Saleem, M. A., Malhotra, A. & Singhal, P. C., 1 Jun 2013, In: AJP - Renal Physiology. 304, 11, p. F1347-57

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Human Immunodeficiency Virus 78%
  • HIV 78%
  • Actin 31%
  • Cytoskeleton 26%
  31 Citations (Scopus)

• Insulin Directly Stimulates VEGF-A production in the Glomerular Podocyte

  Hale, L. J., Hurcombe, J., Lay, A. C., Santamaría, B., Valverde, A. M., Saleem, M. A., Mathieson, P. W., Welsh, G. I. & Coward, R. J. M., 22 May 2013, In: AJP - Renal Physiology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Insulin 58%
  • Vasculotropin A 58%
  • Vascular Endothelial Growth Factor A 58%
  • Insulin Receptor 25%
  55 Citations (Scopus)

• Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse

  Hale, L. J., Welsh, G. I., Perks, C. M., Hurcombe, J. A., Moore, S. F., Hers, I., Saleem, M., Mathieson, P. W., Murphy, AJ., Jeansson, M., Holly, J. M. P., Hardouin, SN. & Coward, R. J. M., May 2013, In: Journal of Pathology. 230, 1, p. 95-106 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Somatomedin B 100%
  • Insulin-Like Growth Factor II 100%
  • Insulin-Like Growth Factor 2 100%
  • Podocyte 75%
  • Man 25%
  19 Citations (Scopus)

• Morphine induces albuminuria by compromising podocyte integrity

  Lan, X., Rai, P., Chandel, N., Cheng, K., Lederman, R., Saleem, M. A., Mathieson, P. W., Husain, M., Crosson, J. T., Gupta, K., Malhotra, A. & Singhal, P. C., 2013, In: PLoS ONE. 8, 3, p. e55748

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Morphine 100%
  • Podocyte 83%
  • Diaphragm 50%
  • Western Blot 33%
  • Molecule 33%
  26 Citations (Scopus)

• mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN

  Rai, P., Plagov, A., Lan, X., Chandel, N., Singh, T., Lederman, R., Ayasolla, K. R., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A., Chander, P. N. & Singhal, P. C., 1 Aug 2013, In: AJP - Renal Physiology. 305, 3, p. F343-54

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • AIDS-Associated Nephropathy 100%
  19 Citations (Scopus)

• Nef interaction with actin compromises human podocyte actin cytoskeletal integrity

  Tan, R., Patni, H., Tandon, P., Luan, L., Sharma, B., Salhan, D., Saleem, M. A., Mathieson, P. W., Malhotra, A., Husain, M., Upadhya, P. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 51-7 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Zyxin 100%
  • Two-Hybrid Screening 100%
  • Stable Cell 100%
  • Filamin 50%
  • Nef Protein 50%
  23 Citations (Scopus)

• Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN

  Rai, P., Plagov, A., Kumar, D., Pathak, S., Ayasolla, K. R., Chawla, A. K., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., Feb 2013, In: Experimental and Molecular Pathology. 94, 1, p. 255-61 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Human Immunodeficiency Virus 100%
  • Rapamycin 73%
  • HIV 66%
  • HIV-associated Nephropathy 33%
  • HIV Associated Nephropathy 33%
  16 Citations (Scopus)

• Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN)

  Cheng, K., Rai, P., Plagov, A., Lan, X., Mathieson, P. W., Saleem, M. A., Husain, M., Malhotra, A. & Singhal, P. C., 1 Aug 2013, In: Experimental Cell Research. 319, 13, p. 2073-80 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • microRNA 100%
  • Human Immunodeficiency Virus 88%
  • Rapamycin 77%
  • Sirolimus 77%
  • HIV-associated Nephropathy 55%
  11 Citations (Scopus)

• Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx

  Singh, A., Ramnath, R. D., Foster, R. R., Wylie, E. C., Fridén, V., Dasgupta, I., Haraldsson, B., Welsh, G. I., Mathieson, P. W. & Satchell, S. C., 2013, In: PLoS ONE. 8, 2, p. e55852

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Reactive Oxygen Species 100%
  • Species 100%
  • Oxygen 100%
  • Endothelial Cell 77%
  • Cells 77%
  118 Citations (Scopus)

• Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes

  Ishimoto, T., Cara-Fuentes, G., Wang, H., Shimada, M., Wasserfall, C. H., Winter, W. E., Rivard, C. J., Araya, C. E., Saleem, M. A., Mathieson, P. W., Johnson, R. J. & Garin, E. H., Sep 2013, In: Pediatric Nephrology. 28, 9, p. 1803-12 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • CD80 100%
  • Podocyte 80%
  • Patient 69%
  • Serum 69%
  • Minimal Change Disease 50%
  31 Citations (Scopus)
• 2012

  A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

  Roumenina, L. T., Frimat, M., Miller, E. C., Provot, F., Dragon-Durey, M-A., Bordereau, P., Bigot, S., Hue, C., Satchell, S. C., Mathieson, P. W., Mousson, C., Noel, C., Sautes-Fridman, C., Halbwachs-Mecarelli, L., Atkinson, J. P., Lionet, A. & Fremeaux-Bacchi, V., 3 May 2012, In: Blood. 119, 18, p. 4182-91 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Atypical Hemolytic Uremic Syndrome 100%
  • Patient 80%
  • Complement Factor H 60%
  • Serum 40%
  • Gene 40%
  109 Citations (Scopus)

• Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes

  Slater, S. C., Ramnath, R. D., Uttridge, K., Saleem, M. A., Cahill, P. A., Mathieson, P. W., Welsh, G. I. & Satchell, S. C., 2012, In: International Journal of Biochemistry and Cell Biology. 44, 9, p. 1482-90 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Shear Stress 100%
  • Endothelial Cell 55%
  • Kruppel Like Factor 2 55%
  • Podocyte 33%
  • Phosphorylation 22%
  46 Citations (Scopus)

• Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) mutants lose the ability to activate transcription by nuclear hormone receptors

  Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, YT., Zhao, X., Saleem, MA., Mathieson, PW., Bruggerman, LA. & Kao, HY., Feb 2012, In: Journal of Biological Chemistry.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Actinin 100%
  • Mutant 75%
  • Focal Segmental Glomerulosclerosis 75%
  • Mutants 75%
  • Transcription Initiation 37%
  37 Citations (Scopus)

• Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4

  Hamer, R., Molostvov, G., Lowe, D., Satchell, S., Mathieson, P., Ilyas, R., Mitchell, D. A., Lam, F. T., Kashi, H., Tan, L. C., Imray, C., Fletcher, S., Briggs, D., Krishnan, N., Higgins, R. & Zehnder, D., 15 May 2012, In: Transplantation. 93, 9, p. 867-73 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Synthesis 100%
  • Western Blot 80%
  • Cells 60%
  • Monospecific Antibody 60%
  • Endothelium 60%
  15 Citations (Scopus)

• IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

  Rigothier, C., Auguste, P., Welsh, G. I., Lepreux, S., Deminière, C., Mathieson, P. W., Saleem, M. A., Ripoche, J. & Combe, C., 2012, In: PLoS ONE. 7, 5, p. e37695

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • IQGAP1 100%
  • Podocyte 91%
  • Diaphragm 50%
  • Protein 25%
  • Cytoskeleton Protein 25%
  32 Citations (Scopus)

• Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells

  Prabakaran, T., Nielsen, R., Satchell, S. C., Mathieson, P. W., Feldt-Rasmussen, U., Sørensen, S. S. & Christensen, E. I., 2012, In: PLoS ONE. 7, 6, p. e39975

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Somatomedin B Receptor 100%
  • Mannose 6-Phosphate Receptor 100%
  • Galactose 100%
  • Endothelial Cell 88%
  • Sortilin 88%
  24 Citations (Scopus)

• MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation

  Asgeirsdóttir, S. A., van Solingen, C., Kurniati, N. F., Zwiers, P. J., Heeringa, P., van Meurs, M., Satchell, S. C., Saleem, M. A., Mathieson, P. W., Banas, B., Kamps, J. A. A. M., Rabelink, T. J., van Zonneveld, A. J. & Molema, G., 15 Jun 2012, In: AJP - Renal Physiology. 302, 12, p. F1630-9

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • VCAM-1 100%
  • Vascular Cell Adhesion Molecule 1 100%
  • Glomerulus 57%
  • Cells 42%
  • Protein Expression 42%
  89 Citations (Scopus)

• Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse

  Tanabe, K., Lanaspa, M. A., Kitagawa, W., Rivard, C. J., Miyazaki, M., Klawitter, J., Schreiner, G. F., Saleem, M. A., Mathieson, P. W., Makino, H., Johnson, R. J. & Nakagawa, T., 1 May 2012, In: AJP - Renal Physiology. 302, 9, p. F1151-F1160 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Nicorandil 100%
  • Podocyte 54%
  • Diabetic Nephropathy 45%
  • Potassium Channels 36%
  • Mouse 27%
  40 Citations (Scopus)

• Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

  Vashistha, H., Singhal, P. C., Malhotra, A., Husain, M., Mathieson, P., Saleem, M. A., Kuriakose, C., Seshan, S., Wilk, A., Delvalle, L., Peruzzi, F., Giorgio, M., Pelicci, P. G., Smithies, O., Kim, H-S., Kakoki, M., Reiss, K. & Meggs, L. G., 15 Dec 2012, In: AJP - Renal Physiology. 303, 12, p. F1629-40

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Phenotype 100%
  • Kidney 66%
  • Akita Mouse 66%
  • Protein P53 50%
  • Gene 50%
  10 Citations (Scopus)

• Podocyte culture: tricks of the trade

  Ni, L., Saleem, M. & Mathieson, P. W., Aug 2012, In: Nephrology. 17, 6, p. 525-31 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Cells 40%
  • Urinary System 40%
  • Glomerular Capillary 40%
  • Humans 40%
  59 Citations (Scopus)
• 2011

  Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia

  Zhao, S., Gu, Y., Coates, G., Groome, LJ., Saleem, MA., Mathieson, PW. & Wang, Y., Aug 2011, In: Reproductive Sciences. 18(8), p. 772 - 780 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Pre-Eclampsia 80%
  23 Citations (Scopus)

• Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

  Hu, N., Westra, J., Rutgers, A., Doornbos-Van der Meer, B., Huitema, M. G., Stegeman, C. A., Abdulahad, W. H., Satchell, S. C., Mathieson, P. W., Heeringa, P. & Kallenberg, C. G. M., Dec 2011, In: Arthritis Research and Therapy. 13, 6, p. R201 1 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Adhesion 100%
  • ANCA Associated Vasculitis 79%
  • Autoantibody 59%
  • Tumor Necrosis Factor 59%
  • Interleukin 8 59%
  34 Citations (Scopus)

• Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

  van der Veen, BS., Chen, MZ., Muller, R., van Timmeren, MM., Petersen, AH., Lee, PA., Satchell, SC., Mathieson, PW., Saleem, MA., Stegeman, CA., Zwerina, J., Molema, G. & Heeringa, P., Feb 2011, In: Annals of the Rheumatic Diseases. 70(2), p. 356 - 365 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  33 Citations (Scopus)

• Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy

  Sanchez-Nino, MD., Sanz, AB., Carrasco, S., Saleem, MA., Mathieson, PW., Valdivielso, JM., Ruiz-Ortega, M., Egido, J. & Ortiz, A., Jun 2011, In: Nephrology Dialysis Transplantation. 26(6), p. 1797 - 1802 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  144 Citations (Scopus)

• Monocyte- and Endothelial-Derived Microparticles Induce an Inflammatory Phenotype in Human Podocytes

  Eyre, J., Burton, JO., Saleem, MA., Mathieson, PW., Topham, PS. & Brunskill, NJ., Aug 2011, In: Nephron Experimental Nephrology. 18;119(3), p. e58 - e66 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Microparticle 100%
  • Podocyte 71%
  • Monocyte 28%
  • Tumor Necrosis Factor 28%
  • Kidneys 21%
  45 Citations (Scopus)

• Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

  O'Flynn, J., Flierman, R., van der Pol, P., Rops, A., Satchell, SC., Mathieson, PW., van Kooten, C., van der Vlag, J., Berden, JH. & Daha, MR., Aug 2011, In: Molecular Immunology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Nucleosome 100%
  • Complement Component C1q 87%
  • Autoantibodies 75%
  • Complement Activation 25%
  • Lupus Nephritis 25%
  23 Citations (Scopus)

• Phenotypic expression of ADAMTS13 in glomerular endothelial cells

  Tati, R., Kristoffersson, AC., Stahl, AL., Morgelin, M., Motto, D., Satchell, SC., Mathieson, PW., Manea-Hedstrom, M. & Karpman, D., 24 Jun 2011, In: PLoS ONE. 6, 6, 11 p., e21587.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • mice 35%
  • shear stress 11%
  • ultrastructure 10%
  • Skin 7%
  18 Citations (Scopus)

  287 Downloads (Pure)

• The podocyte as a target for therapies-new and old

  Mathieson, PW., Nov 2011, In: Nature Reviews Nephrology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Combination Therapy 54%
  • Injury 27%
  • Kidney 27%
  • Kidneys 27%
  109 Citations (Scopus)

• Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-{kappa}B-dependent pathway

  Shimada, M., Ishimoto, T., Lee, P., Lanaspa, MA., Rivard, CJ., Roncal-Jimenez, CA., Wymer, DT., Yarnabe, H., Mathieson, PW., Saleem, MA., Garin, EH. & Johnson, RJ., May 2011, In: Nephrology Dialysis Transplantation.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  77 Citations (Scopus)
• 2010

  DC-specific ICAM-3-grabbing nonintegrin mediates internalization of HIV-1 into human podocytes

  Mikulak, J., Teichberg, S., Arora, S., kumar, D., Kumar, D., Yadav, A., Salhan, D., Pullagura, S., Mathieson, PW., Saleem, MA. & Singhal, P., Sep 2010, In: AJP - Renal Physiology. 299(3), p. F664 - F673 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Human Immunodeficiency Virus 1 100%
  • Podocyte 80%
  • Internalization 40%
  • CD209 Antigen 40%
  • DC-SIGN 40%
  23 Citations (Scopus)

• Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

  Summers, SA., van der Veen, BS., O'Sullivan, KM., Gan, PY., Ooi, JD., Heeringa, P., Satchell, SC., Mathieson, PW., Saleem, MA., Visvanathan, K., Holdsworth, SR. & Kitching, AR., Dec 2010, In: Kidney International. 78(12), p. 1263 - 1274 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Neutrophil 100%
  • Toll Like Receptor 4 100%
  • TLR4 100%
  • Injury 66%
  • Diseases 50%
  49 Citations (Scopus)

• PDGF-C Mediates Glomerular Capillary Repair

  Boor, P., van Roeyen, CR., Kunter, U., Villa, L., Bucher, E., Hohenstein, B., Hugo, CP., Eriksson, U., Satchell, SC., Mathieson, PW., Eitner, F. & Ostendorf, T., Jul 2010, In: American Journal of Pathology. 177(1), p. 58 - 69 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Platelet Derived Growth Factor C 100%
  • Endothelial Cells 72%
  • Area 27%
  • Thrombotic Thrombocytopenic Purpura 27%
  • Rats 18%
  35 Citations (Scopus)

• Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product

  Matsumoto, T., Hess, S., Kajiyama, H., Sakairi, T., Saleem, MA., Mathieson, PW., Nojima, Y. & Kopp, JB., Oct 2010, In: AJP - Renal Physiology. 299(4), p. F776 - F784 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocyte 100%
  • Cytochromes 60%
  • Epithelial Cells 40%
  • Proteome 40%
  • Humans 20%
  14 Citations (Scopus)

• Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study

  Asgeirsdottir, SA., Talman, EG., de Graaf, IA., Kamps, JA., Satchell, SC., Mathieson, PW., Ruiters, MH. & Molema, G., Jan 2010, In: Journal of Controlled Release. 25;141(2), p. 241 - 251 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • In Vitro Techniques 13%
  32 Citations (Scopus)