COMBINED EXPERIMENTAL AND COMPUTATIONAL INVESTIGATIONS OF A NUCLEOPHILLIC DISPLACEMENT REACTION WITH A HYDRIDE LEAVING GROUP

Status	Finished
Effective start/end date	1/04/09 → 1/04/12

A catalytic role for methionine revealed by a combination of computation and experiments on phosphite dehydrogenase
Ranaghan, K. E., Hung, J. E., Bartlett, G. J., Mooibroek, T. J., Harvey, J. N., Woolfson, D. N., van der Donk, W. A. & Mulholland, A. J., 2014, In: Chemical Science. 5, 6, p. 2191-2199 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
32 Citations (Scopus)
Analysis of chorismate mutase catalysis by QM/MM modelling of enzyme-catalysed and uncatalysed reactions
Claeyssens, F., Ranaghan, K. E., Lawan, N., Macrae, S. J., Manby, F. R., Harvey, J. N. & Mulholland, A. J., 2011, In: Organic and Biomolecular Chemistry. 9, 5, p. 1578-1590 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
54 Citations (Scopus)
Protein dynamics and enzyme catalysis: insights from simulations
McGeagh, J. D., Ranaghan, K. E. & Mulholland, A. J., Aug 2011, In: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1814, 8, p. 1077-92 16 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
74 Citations (Scopus)

Project Details