COMBINED EXPERIMENTAL AND COMPUTATIONAL INVESTIGATIONS OF A NUCLEOPHILLIC DISPLACEMENT REACTION WITH A HYDRIDE LEAVING GROUP

Status	Finished
Effective start/end date	1/04/09 → 1/04/12

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases
Hoff, J. F., Goudar, K. E., Beer, M., Hinchliffe, P., Shaw, J. M., Tooke, C. L., Takebayashi, Y., Mulholland, A. J., Schofield, C. J. & Spencer, J., 30 Oct 2024, bioRxiv.org.
Research output: Working paper › Preprint

Open Access
A catalytic role for methionine revealed by a combination of computation and experiments on phosphite dehydrogenase
Ranaghan, K. E., Hung, J. E., Bartlett, G. J., Mooibroek, T. J., Harvey, J. N., Woolfson, D. N., van der Donk, W. A. & Mulholland, A. J., 2014, In: Chemical Science. 5, 6, p. 2191-2199 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
35 Citations (Scopus)
Analysis of chorismate mutase catalysis by QM/MM modelling of enzyme-catalysed and uncatalysed reactions
Claeyssens, F., Ranaghan, K. E., Lawan, N., Macrae, S. J., Manby, F. R., Harvey, J. N. & Mulholland, A. J., 2011, In: Organic and Biomolecular Chemistry. 9, 5, p. 1578-1590 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
62 Citations (Scopus)

Project Details