Do biased agonists at the mu-opioid receptor induce different patterns of receptor phosphorylation?

Research output

Research output per year 2012 2013 2014 2015 2015

• 10 Article (Academic Journal)

Research output per year

Research output per year

Search results

• 2015

  Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine

  Hill, R., Lyndon, A., Withey, S., Roberts, J., Kershaw, Y., MacLachlan, J., Lingford-Hughes, A., Kelly, E., Bailey, C., Hickman, M. & Henderson, G., 9 Sep 2015, (E-pub ahead of print) In: Neuropsychopharmacology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Morphine 100%
  • Alcohol 90%
  • Opiate 63%
  • Opioid 63%
  • Respiration Depression 54%
  50 Citations (Scopus)

• Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

  Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., 26 May 2015, In: Molecular Pharmacology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Desensitization 100%
  • Agonist 40%
  • Receptor 20%
  • Guanine Nucleotide Binding Protein 20%
  • Opiate Receptor 20%
  56 Citations (Scopus)

• The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

  Alexander, S. P., Davenport, A. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Davies, J. A. & CGTP Collaborators, Dec 2015, In: British Journal of Pharmacology. 172, 24, p. 5744-869 126 p.

  Research output: Contribution to journal › Article (Academic Journal)

  • G Protein Coupled Receptor 100%
  • Drug 75%
  • Chemotherapeutic Agent 75%
  • Receptor 50%
  • Ligand 50%
  485 Citations (Scopus)
• 2014

  Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor

  Cooke, A. E., Oldfield, S., Krasel, C., Mundell, S. J., Henderson, G. & Kelly, E., 4 Apr 2014, In: British Journal of Pharmacology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Morphine 100%
  • Internalization 57%
  • Receptor 57%
  • Wild Type 42%
  • Aptitude 28%
  5 Citations (Scopus)

• The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours

  Kelly, E., Mundell, S. J., Sava, A., Roth, A. L., Felici, A., Maltby, K., Nathan, P. J., Bullmore, E. T. & Henderson, G., 29 Jun 2014, In: Psychopharmacology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Naloxone 100%
  • Naltrexone 100%
  • Inverse Agonism 60%
  • Antagonist 40%
  • Binding Assay 40%
  14 Citations (Scopus)
• 2013

  Efficacy and ligand bias at the μ-opioid receptor

  Kelly, E., Aug 2013, In: British Journal of Pharmacology. 169, 7, p. 1430-46 17 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Agonist 100%
  • Aptitude 50%
  • Receptor 50%
  • Ligand 50%
  • G Protein Coupled Receptor 50%
  100 Citations (Scopus)

• Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons

  Llorente, J., Withey, S., Rivero, G., Cunningham, M., Cooke, A., Saxena, K., McPherson, J., Oldfield, S., Dewey, W. L., Bailey, C. P., Kelly, E. & Henderson, G., Aug 2013, In: Molecular Pharmacology. 84, 2, p. 252-60 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Morphine 100%
  • Neuron 36%
  • Locus Coeruleus 36%
  • Protein Kinase C 18%
  • Dephosphorylation 9%
  11 Citations (Scopus)

• Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor

  Chen, Y-J., Oldfield, S., Butcher, A. J., Tobin, A. B., Saxena, K., Gurevich, V. V., Benovic, J. L., Henderson, G. & Kelly, E., Jan 2013, In: Journal of Neurochemistry. 124, 2, p. 189-199 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • C-Terminus 100%
  • Phosphorylation 83%
  • Fusion Protein 33%
  • Glutathione S-Transferase 33%
  • Regulatory Mechanism 33%
  36 Citations (Scopus)

• Ligand bias at the mu-opioid receptor

  Kelly, E., Feb 2013, In: Biochemical Society Transactions. 41, p. 218-224 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Ligand 100%
  • Agonist 80%
  • Mu Opiate Receptor 80%
  • μ-Opioid Receptor 80%
  • Drug 40%
  16 Citations (Scopus)
• 2012

  Endocytosis of G protein-coupled receptors is regulated by clathrin light chain phosphorylation

  Ferreira, F., Foley, M., Cooke, A., Cunningham, M., Smith, G., Woolley, R., Henderson, G., Kelly, E., Mundell, S. & Smythe, E., Aug 2012, In: Current Biology. 22, 15, p. 1361-70 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Clathrin Heavy Chains 23%
  37 Citations (Scopus)