Exploiting the inhibition of vascular smooth muscle cell proliferation and intimal thickening

Project Details

Description

The build-up of fatty deposits in arteries causes narrowing of blood vessels, restricted blood flow and deprivation of oxygen, leading to heart and circulatory diseases. Conventional treatment for the narrowing of arteries is to implant a stent in the vessel or to conduct bypass surgery to redirect blood flow around the blockage. However, it is common following both procedures for the vessel to re-narrow – a process called restenosis. This is caused by the growth and movement of vascular smooth muscle cells (VSMCs) following damage to the blood vessel. Although stents that release certain drugs can prevent this regrowth and thickening of tissue, they also prevent normal blood vessel repair.

My research project will determine whether a modified protein could be used as a treatment to halt the overgrowth of VSMCs following treatment. The results could lead to urgently-needed better treatment options for people with coronary artery disease.
StatusFinished
Effective start/end date2/10/172/10/20