Feasibility Study of the Cumulus Neuroscience Platform for In Home Data Collection

The study will investigate whether in-home measurement of neurocognitive function is feasible using a novel cloud-based neuroscience platform, ‘Cumulus’. If successful, this study will provide evidence supporting the use of Cumulus as a more sensitive research tool in clinical trials. The study will collect data using Cumulus and compare this data against standard measurement tools
typically used within the research setting.

Cumulus has been designed to measure brain function, including domains of neurophysiology, speech, cognition, sleep and mood. Each separate assessment of these domains has been extensively field tested or validated or is substantially similar to a validated assessment. However, this is the first time that these assessments have been brought together for frequent sampling in a real-world setting. People with early stage (also known as mild) dementia and a matched cohort of healthy adults will be asked to use the platform, at home, over the course of one year to assess the feasibility of this approach. The matched cohort of healthy adults are included to provide control data for comparison and provide a proxy for our targeted application to measure group-level
differences between a more rapidly declining group (e.g. those on placebo) and a more slowly declining group (e.g. those on an effective new therapy).

The Cumulus platform consists of the Cumulus electroencephalography (EEG) headset, a tablet based Cumulus application (app) to present game-like tasks, a second EEG headset (the Dreem headband) for intermittent use overnight to measure patterns and stages of sleep, and a cloud infrastructure that securely collects the research data.

Study still in data collection phase - no formal data analysis yet.