FRESCO: Efficient, Flexible Synthesis of Molecules with Tailored Shapes: from Photoswitchable Helices to anti-Cancer Compounds

Research output

Research output per year 2016 2017 2018 2019 2021

• 30 Article (Academic Journal)
• 2 Review article (Academic Journal)
• 1 Letter (Academic Journal)

Research output per year

Research output per year

Search results

• 2021

  Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains

  Guo, L., Dutton, O. J., Kucukdisli, M., Davy, M., Wagnières, O., Butts, C. P., Myers, E. L. & Aggarwal, V. K., 13 Oct 2021, In: Journal of the American Chemical Society. 143, 40, p. 16682-16692 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Side Chain 100%
  • Substituent 100%
  • Diamond 100%
  • Nuclear Magnetic Resonance 100%
  • Conformation 100%
  7 Citations (Scopus)

  74 Downloads (Pure)

• Divergent, Strain‐Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation

  Gregson, C. H. U., Noble, A. & Aggarwal, V. K., 22 Mar 2021, In: Angewandte Chemie - International Edition. 60, 13, p. 7360-7365 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Azetidine Derivative 100%
  • Methanol 100%
  • Azetidine 100%
  • formation 100%
  • Pharmaceutical Chemistry 50%
  38 Citations (Scopus)

  50 Downloads (Pure)
• 2020

  Decarboxylative Conjunctive Cross-coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis

  Mega, R. S., Duong, V. K., Noble, A. & Aggarwal, V. K., 9 Mar 2020, In: Angewandte Chemie - International Edition. 59, 11, p. 4375-4379 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Carboxylic Acid 100%
  • Radical Addition 50%
  • Amino Acid 50%
  117 Citations (Scopus)

  300 Downloads (Pure)

• Difunctionalization of C–C σ Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins

  Bennett, S., Fawcett, A., Denton, E., Biberger, T., Fasano, V., Winter, N. & Aggarwal, V. K., 4 Sept 2020, In: Journal of the American Chemical Society. 142, 39, p. 16766–16775 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Boronate 100%
  • Electrophile 100%
  • Diastereoselectivity 50%
  • Strain Energy 50%
  • Multi-Step Reaction 25%
  84 Citations (Scopus)

  227 Downloads (Pure)

• Odd–even alternations in helical propensity of a homologous series of hydrocarbons

  Pradeilles, J. A., Zhong, S., Baglyas, M., Tarczay, G., Butts, C. P., Myers, E. L. & Aggarwal, V. K., 2 Mar 2020, In: Nature Chemistry. 12, p. 475-480 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hydrophobic 100%
  • Odd Number 100%
  • Computational Analysis 100%
  • Soft Material 100%
  • Self-Assembled Monolayers 100%
  37 Citations (Scopus)

  434 Downloads (Pure)

• Stereospecific 1,2‐Migrations of Boronate Complexes Induced by Electrophiles

  Wang, H., Jing, C., Noble, A. & Aggarwal, V. K., 22 Jul 2020, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Boronate 100%
  • Electrophile 100%
  • Chemistry 20%
  • Coupling Reaction 20%
  • Asymmetric Synthesis 20%
  118 Citations (Scopus)

  162 Downloads (Pure)
• 2019

  1,2-Boron Shifts of β-Boryl Radicals Generated from Bis-boronic Esters Using Photoredox Catalysis

  Kaiser, D., Noble, A., Fasano, V. & Aggarwal, V. K., 11 Sept 2019, In: Journal of the American Chemical Society. 141, 36, p. 14104-14109 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Alkene 100%
  • Cyclization Reaction 100%
  • Cascade Reaction 100%
  • Photoredox 100%
  • Photoredox Catalysis 100%
  91 Citations (Scopus)

  199 Downloads (Pure)

• Carbopalladation of C–C σ-bonds enabled by strained boronate complexes

  Fawcett, A., Biberger, T. & Aggarwal, V. K., Feb 2019, In: Nature Chemistry. 11, 2, p. 117-122 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Palladium 100%
  • Boronate 100%
  • Reaction Step 66%
  • Cyclobutane 66%
  • Oxidative Addition 33%
  161 Citations (Scopus)

  539 Downloads (Pure)

• Catalyst-Free Deaminative Functionalizations of Primary Amines via Photoinduced Single-Electron Transfer

  Wu, J., Grant, P. S., Li, X., Noble, A. & Aggarwal, V. K., 16 Apr 2019, In: Angewandte Chemie - International Edition. 58, 17, p. 5697-5701 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Primary Amine 100%
  • Electron Transport 100%
  • Alkynylation 100%
  • Allylation 100%
  • Alkylation 100%
  279 Citations (Scopus)

  186 Downloads (Pure)

• Complex Boron-Containing Molecules through a 1,2-Metalate Rearrangement/anti-S _N 2′ Elimination/Cycloaddition Reaction Sequence

  Tillin, C., Bigler, R., Calo-lapido, R., Collins, B., Noble, A. & Aggarwal, V., 1 Jan 2019, In: SYNLETT. 30, 4, p. 449-453 5 p.

  Research output: Contribution to journal › Letter (Academic Journal) › peer-review

  Open Access

  File

  • Cycloaddition 97%
  7 Citations (Scopus)

  517 Downloads (Pure)

• Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-S_N2′ Elimination/Rearomatizing Allylic Suzuki–Miyaura Reaction Sequence

  Rubial, B., Collins, B. S. L., Bigler, R., Aichhorn, S., Noble, A. & Aggarwal, V. K., 28 Jan 2019, In: Angewandte Chemie - International Edition. 58, 5, p. 1366-1370 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Elimination 100%
  • Benzylamine Derivative 100%
  • Benzylamine 100%
  • Palladium 33%
  • Boronate 33%
  16 Citations (Scopus)

  392 Downloads (Pure)

• Photoinduced Deoxygenative Borylations of Aliphatic Alcohols

  Wu, J., Baer, R., Guo, L., Noble, A. & Aggarwal, V. K., 15 Oct 2019, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Aliphatic Alcohol 100%
  • Borylation 100%
  • Deoxygenation 50%
  • Diboron 50%
  • Photocatalyst 50%
  120 Citations (Scopus)

  440 Downloads (Pure)

• Photoredox-Catalyzed Cyclobutane Synthesis by a Deboronative Radical Addition–Polar Cyclization Cascade

  Shu, C., Noble, A. & Aggarwal, V. K., 18 Mar 2019, In: Angewandte Chemie - International Edition. 58, 12, p. 3870-3874 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Alkene 100%
  • Photoredox 100%
  • Radical Addition 100%
  • Cyclobutane 100%
  • Halide 50%
  119 Citations (Scopus)

  354 Downloads (Pure)

• Strain-Release-Driven Homologation of Boronic Esters: Application to the Modular Synthesis of Azetidines

  Fawcett, A., Murtaza, A., Gregson, C. H. U. & Aggarwal, V. K., 20 Mar 2019, In: Journal of the American Chemical Society. 141, 11, p. 4573–4578 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Azetidine 100%
  • Chemistry 25%
  • Stereoselective Synthesis 25%
  • Boronate 25%
  • Lithium 25%
  123 Citations (Scopus)

  475 Downloads (Pure)

• Strain Release of Donor–Acceptor Cyclopropyl Boronate Complexes

  Gregson, C. H. U., Ganesh, V. & Aggarwal, V. K., 3 May 2019, In: Organic Letters. 21, 9, p. 3412-3416 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Boronate 100%
  • Ring Opening Reaction 33%
  • Lewis Acid 33%
  • Cyclopropane 33%
  • Alkylation 33%
  28 Citations (Scopus)

  193 Downloads (Pure)
• 2018

  Chiral Aniline Synthesis via Stereospecific C(sp3)–C(sp2) Coupling of Boronic Esters with Aryl Hydrazines

  Ganesh, V., Noble, A. & Aggarwal, V. K., 5 Oct 2018, In: Organic Letters. 20, 19, p. 6144-6147 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Substituted Aniline 100%
  • Hydrazinyl 100%
  • Transition Metal 100%
  • Acylation 100%
  8 Citations (Scopus)

  333 Downloads (Pure)

• Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides

  Zhurakovskyi, O., Türkmen, Y. E., Löffler, L. E., Moorthie, V. A., Chen, C. C., Shaw, M. A., Crimmin, M. R., Ferrara, M., Ahmad, M., Ostovar, M., Matlock, J. V. & Aggarwal, V. K., 22 Jan 2018, In: Angewandte Chemie - International Edition. 57, 5, p. 1346–1350 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Sulfur Ylide 100%
  • Cyclopiazonic Acid 100%
  • Alkene 50%
  • Aziridine 50%
  • Natural Product 50%
  39 Citations (Scopus)

  397 Downloads (Pure)

• Enantiospecific Three-Component Alkylation of Furan and Indole

  Silvi, M., Schrof, R., Noble, A. & Aggarwal, V. K., 20 Mar 2018, In: Chemistry - A European Journal. 24, 17, p. 4279-4282 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Boronate 100%
  • Indole 100%
  • Furan 100%
  • Alkylation 100%
  • Excited State 25%
  38 Citations (Scopus)

  342 Downloads (Pure)

• Photoinduced Deaminative Borylation of Alkylamines

  Wu, J., He, L., Noble, A. & Aggarwal, V. K., 29 Aug 2018, In: Journal of the American Chemical Society. 140, 34, p. 10700-10704 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Borylation 100%
  • Alkylamine 100%
  • Aliphatic Amine 100%
  • Electron Donor 33%
  • Diboron 33%
  317 Citations (Scopus)

  623 Downloads (Pure)

• Stereo- and Regiocontrolled Methylboration of Terminal Alkynes

  Zhurakovskyi, O., Dias, R. M. P., Noble, A. & Aggarwal, V. K., 18 May 2018, In: Organic Letters. 20, 10, p. 3136-3139 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Alkyne 100%
  • Regioselectivity 50%
  • Transmetalation 50%
  • Stereoselectivity 50%
  17 Citations (Scopus)

  421 Downloads (Pure)

• Synthesis of Functionalized Cyclopropanes from Carboxylic Acids via a Radical Addition-Polar Cyclization Cascade

  Shu, C., Mega, R. S., Andreassen, B. J., Noble, A. & Aggarwal, V. K., 19 Nov 2018, In: Angewandte Chemie - International Edition. 57, 47, p. 15430-15434 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Alkene 100%
  • Radical Addition 100%
  • Cyclopropane 100%
  • Carboxylic Acid 100%
  • Photocatalyst 33%
  143 Citations (Scopus)

  327 Downloads (Pure)
• 2017

  50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling

  Armstrong, R. J. & Aggarwal, V. K., 1 Aug 2017, In: Synthesis (Germany). 49, 15, p. 3323-3336 14 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Transition Metal 100%
  • olefination 100%
  • Transition-Metal Catalyst 12%
  • Alkene 12%
  • Borane 12%
  164 Citations (Scopus)

  687 Downloads (Pure)

• Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

  Collins, B. S. L., Wilson, C. M., Myers, E. L. & Aggarwal, V. K., 18 Sept 2017, In: Angewandte Chemie - International Edition. 56, 39, p. 11700-11733 34 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Asymmetric Synthesis 100%
  • Stereoselective Synthesis 33%
  • Hydroboration 33%
  • Halide 33%
  • Brown 33%
  242 Citations (Scopus)

  931 Downloads (Pure)

• Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

  Smith, J. R., Collins, B. S. L., Hesse, M. J., Graham, M. A., Myers, E. L. & Aggarwal, V. K., 30 Jun 2017, In: Journal of the American Chemical Society. 139, 27, p. 9148-9151 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Alkene 100%
  • Hydroboration 100%
  • Rhodium 100%
  • Diboron 33%
  101 Citations (Scopus)

  411 Downloads (Pure)

• Enantiospecific sp²–sp³ Coupling of ortho- and para-Phenols with Secondary and Tertiary Boronic Esters

  Wilson, C. M., Ganesh, V., Noble, A. & Aggarwal, V. K., 18 Dec 2017, In: Angewandte Chemie - International Edition. 56, 51, p. 16318-16322 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Oxygen 20%
  27 Citations (Scopus)

  332 Downloads (Pure)

• Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence

  Aichhorn, S., Bigler, R., Myers, E. L. & Aggarwal, V. K., 29 Jun 2017, (E-pub ahead of print) In: Journal of the American Chemical Society. 139, 28, p. 9519-9522 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Benzylamine 100%
  • Coupling Reaction 33%
  • Boronate 33%
  • Lewis Acid 33%
  36 Citations (Scopus)

  460 Downloads (Pure)

• Iterative assembly line synthesis of polypropionates with full stereocontrol

  Bootwicha, T., Feilner, J. M., Myers, E. L. & Aggarwal, V. K., 1 Sept 2017, In: Nature Chemistry. 9, 9, p. 896-902 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Polyketide 100%
  • Natural Product 100%
  • Methanol 50%
  • Stereochemistry 50%
  • Stereoisomer 50%
  77 Citations (Scopus)

  534 Downloads (Pure)

• Photoinduced decarboxylative borylation of carboxylic acids

  Fawcett, A., Pradeilles, J., Wang, Y., Mutsuga, T., Myers, E. L. & Aggarwal, V. K., 21 Jul 2017, In: Science. 357, 6348, p. 283-286 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Borylation 100%
  • Carboxylic Acid 100%
  • Diboron 40%
  • Ambient Reaction Temperature 20%
  • Pinacol 20%
  568 Citations (Scopus)

  878 Downloads (Pure)

• Selective uni- and bidirectional homologation of diborylmethane

  Blair, D. J., Tanini, D., Bateman, J. M., Scott, H. K., Myers, E. L. & Aggarwal, V. K., 1 Apr 2017, In: Chemical Science. 8, 4, p. 2898-2903 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Alkene 100%
  • Purity 50%
  • Enantioselectivity 50%
  • Diastereoselectivity 50%
  • Steric Hindrance 50%
  65 Citations (Scopus)

  417 Downloads (Pure)

• Stereospecific Allylic Functionalization: The Reactions of Allylboronate Complexes with Electrophiles

  García-Ruiz, C., Chen, J. L. Y., Sandford, C., Feeney, K. M. J., Lorenzo, P., Berionni, G., Mayr, H. & Aggarwal, V. K., 13 Oct 2017, In: Journal of the American Chemical Society. 139, 43, p. 15324-15327 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Electrophile 100%
  • Fluorine 25%
  • Nucleophilicity 25%
  • Trifluoromethyl Group 25%
  • Imine 25%
  53 Citations (Scopus)

  389 Downloads (Pure)

• Stereospecific functionalizations and transformations of secondary and tertiary boronic esters

  Sandford, C. & Aggarwal, V. K., 29 Mar 2017, (E-pub ahead of print) In: Chemical Communications. 53, 40, p. 5481-5494 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • formation 100%
  • Catalytic Method 50%
  • Hydrogen Bond 50%
  468 Citations (Scopus)

  562 Downloads (Pure)

• Synergy of synthesis, computation and NMR reveals correct baulamycin structures

  Wu, J., Lorenzo, P., Zhong, S., Ali, M., Butts, C. P., Myers, E. L. & Aggarwal, V. K., 27 Jul 2017, In: Nature. 547, 7664, p. 436-440 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • NMR Spectroscopy 100%
  • Natural Product 100%
  • Magnetism 100%
  • Nuclear Magnetic Resonance 100%
  • Density Functional Theory 50%
  114 Citations (Scopus)

  863 Downloads (Pure)
• 2016

  Full chirality transfer in the synthesis of hindered tertiary boronic esters under in situ lithiation–borylation conditions

  Blair, D., Zhong, S., Hesse, M., Zabaleta, N., Myers, E. & Aggarwal, V., 18 Apr 2016, In: Chemical Communications. 52, 30, p. 5289-5292 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Chirality 100%
  • Enantiopurity 50%
  • Carbamates 50%
  8 Citations (Scopus)

  318 Downloads (Pure)