Health Technology Assessment for NIHR 2010-2012: The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomized, double-blind, placebo-controlled, parallel study (MENDS).

  • Allport, Tom D (Principal Investigator)
  • Emond, Alan M (Co-Investigator)
  • Ellis, Matthew E (Co-Investigator)
  • Appleton, Richard (Principal Investigator)
  • Gringras, Paul (Principal Investigator)

Project Details


Multi-centre HTA-funded evaluation: co-applicant and local PI

Key findings

Study found that melatonin increases total sleep time in children with neurodevelopmental delay but that the increase is not clinically worthwhile and that melatonin is effective in reducing sleep-onset latency in children with neurodevelopmental delay and that the reduction is both clinically important and statistically significant.
Effective start/end date1/05/071/10/12


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