Identifying the role of NMDA receptors in STP through investigation of synaptic plasticity and discovery of novel subtype-specific antagonists

Jane, David E (Principal Investigator)

6 Article (Academic Journal)
2 Review article (Academic Journal)

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2019
Positive and Negative Allosteric Modulators of N-Methyl- d -aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action
Burnell, E. S., Irvine, M., Fang, G., Sapkota, K., Jane, D. E. & Monaghan, D. T., 10 Jan 2019, In: Journal of Medicinal Chemistry. 62, 1, p. 3-23 21 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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53 Citations (Scopus)

416 Downloads (Pure)
2017
A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
Chopra, D. A., Sapkota, K., Irvine, M. W., Fang, G., Jane, D. E., Monaghan, D. T. & Dravid, S. M., 31 Jul 2017, In: Scientific Reports. 7, 11 p., 6933.
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9 Citations (Scopus)

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Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives
Sapkota, K., Irvine, M. W., Fang, G., Burnell, E. S., Bannister, N., Volianskis, A., Culley, G. R., Dravid, S. M., Collingridge, G. L., Jane, D. E. & Monaghan, D. T., Oct 2017, In: Neuropharmacology. 125, p. 64-79 16 p.
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16 Citations (Scopus)

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Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus
France, G., Fernández-Fernández, D., Burnell, E. S., Irvine, M. W., Monaghan, D. T., Jane, D. E., Bortolotto, Z. A., Collingridge, G. L. & Volianskis, A., 1 Jan 2017, In: Neuropharmacology. 112, A, p. 76-83 8 p.
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33 Citations (Scopus)

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2015
An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo
Wallis, J., Irvine, M., Jane, D., Lodge, D., Collingridge, G. & Bortolotto, Z., 23 Oct 2015, In: Hippocampus. 25, 11, p. 1407-1417 10 p.
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7 Citations (Scopus)

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Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators
Irvine, M. W., Fang, G., Eaves, R., Mayo-Martin, M. B., Burnell, E. S., Costa, B. M., Culley, G. R., Volianskis, A., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., Jun 2015, In: Synthesis (Germany). 47, 11, p. 1593-1610 18 p., ss-2014-t0697-op.
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10 Citations (Scopus)

375 Downloads (Pure)

Identifying the role of NMDA receptors in STP through investigation of synaptic plasticity and discovery of novel subtype-specific antagonists

Research output

Search results

Positive and Negative Allosteric Modulators of N-Methyl- d -aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo

Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators