Molecular and functional characterisation of the neuronal specific de-ubiquitinase UCH-L1 and its role in neuronal polarity and axonal outgrowth

Search results

• 2017

  Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity

  Luo, J., Henley, J., Gurung, S., Guo, C., Wilkinson, K. & Lee, L., 26 Jul 2017, In: Journal of Toxicological Sciences. 42, 5, p. 529-538 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cytotoxicity 100%
  • Sumoylation 100%
  • Caspase 100%
  • SENP3 100%
  • Caspase 3 100%

  16 Citations (Scopus)

  362 Downloads (Pure)

• SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

  Rocca, D., Wilkinson, K. & Henley, J., 13 Apr 2017, In: Scientific Reports. 7, 1, 12 p., 877.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Morphogenesis 100%
  • Sumoylation 100%
  • FOXP1 100%
  • Neuronal Activity 12%
  • Transcriptional Repressor 12%

  39 Citations (Scopus)

  447 Downloads (Pure)

• 2016

  Ubiquitin C-terminal hydrolase L1 (UCH-L1): Structure, distribution and roles in brain function and dysfunction

  Bishop, P., Rocca, D. & Henley, J., Aug 2016, In: Biochemical Journal. 473, 16, p. 2453-2462 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • C-Terminus 100%
  • Brain Function 100%
  • Ubiquitin C 100%
  • Hydrolase 100%
  • Neurodegenerative Disorder 14%

  251 Citations (Scopus)

  793 Downloads (Pure)

• 2014

  The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons

  Bishop, P., Rubin, P., Thomson, A. R., Rocca, D. & Henley, J. M., 26 Dec 2014, In: Journal of Biological Chemistry. 289, 52, p. 36140-9 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • C-Terminus 100%
  • Ubiquitin C 100%
  • Protein Stability 100%
  • Hydrolase 100%
  • Parkinson's Disease 7%

  35 Citations (Scopus)

• 2013

  In vivo characterization of the properties of SUM01-specific monobodies

  Berndt, A., Wilkinson, K. A., Heimann, M. J., Bishop, P. & Henley, J. M., 15 Dec 2013, In: Biochemical Journal. 456, p. 385-395 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • SUMO2 100%
  • Sumoylation 66%
  • Enzyme 33%
  • Ubiquitin 33%
  • Recombinant Protein 33%

  5 Citations (Scopus)

• Receptor trafficking and the regulation of synaptic plasticity by SUMO

  Luo, J., Ashikaga, E., Rubin, P. P., Heimann, M. J., Hildick, K. L., Bishop, P., Girach, F., Josa-Prado, F., Tang, L. T. H., Carmichael, R. E., Henley, J. M. & Wilkinson, K. A., Dec 2013, In: NeuroMolecular Medicine. 15, 4, p. 692-706 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Synapses 51%
  • Ubiquitin 18%
  • Learning 13%

  33 Citations (Scopus)

• RIM1α SUMOylation is required for fast synaptic vesicle exocytosis

  Girach, F., Craig, T. J., Henley, J. M. & Henley, J. M., Nov 2013, In: Cell Reports.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Synaptic Vesicle 100%
  • Sumoylation 100%
  • Exocytosis 100%
  • Neurotransmitter 33%
  • Lysine 33%

  48 Citations (Scopus)

• SUMOylation Is Required for Glycine-Induced Increases in AMPA Receptor Surface Expression (ChemLTP) in Hippocampal Neurons

  Jaafari, N., Konopacki, F. A., Kantamneni, S., Rubin, P., Craig, T. J., Wilkinson, K. A. & Henley, J. M., 11 Jan 2013, In: PLOS ONE. 8, 1, 9 p., 52345.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • AMPA Receptor 100%
  • Sumoylation 100%
  • SUMO 1 Protein 60%
  • Messenger RNA 60%
  • Receptor Trafficking 40%

  56 Citations (Scopus)