MRC UoB UNITE Unit - programme 3 - Research Outputs

2020

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

Bell, J. A., Bull, C. J., Gunter, M. J., Carslake, D., Mahajan, A., Davey Smith, G., Timpson, N. J. & Vincent, E. E., 1 Jul 2020, In: Diabetes Care. dc192348.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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29 Citations (Scopus)

310 Downloads (Pure)

2019

Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

Haworth, S., Mitchell, R., Corbin, L., Wade, K., Dudding, T., Budu-Aggrey, A., Carslake, D., Hemani, G., Paternoster, L., Davey Smith, G., Davies, N., Lawson, D. & Timpson, N., 1 Dec 2019, In: Nature Communications. 10, 1, 9 p., 333.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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212 Citations (Scopus)

542 Downloads (Pure)

Association between fat mass through adolescence and arterial stiffness: a population-based study from The Avon Longitudinal Study of Parents and Children

Dangardt, F., Charakida, M., Georgiopoulos, G., Chiesa, S., Rapala, A., Wade, K., Hughes, A. D., Timpson, N., Pateras, K., Finer, N., Sattar, N., Davey Smith, G., Lawlor, D. & Deanfield, J., 1 Jul 2019, In: Lancet Child and Adolescent Health. 3, 7, p. 474-481 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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65 Citations (Scopus)

378 Downloads (Pure)

Combined Association of Body Mass Index and Alcohol Consumption with Biomarkers for Liver Injury and Incidence of Liver Disease: A Mendelian Randomization Study

Carter, A., Borges, C., Benn, M., Tybjaerg-Hansen, A., Davey Smith, G., Nordestgaard, B. & Lawlor, D., Mar 2019, In: JAMA Network Open. 2, 3, p. e190305 14 p., e190305.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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28 Citations (Scopus)

374 Downloads (Pure)

Is Population Structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Lawson, D., Davies, N., Haworth, S., Ashraf, B., Howe, L., Crawford, A., Hemani, G., Davey Smith, G. & Timpson, N., 27 Apr 2019, (E-pub ahead of print) In: Human Genetics. 19 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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73 Citations (Scopus)

358 Downloads (Pure)

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Haworth, S., Shapland, C. Y., Hayward, C., Prins, B. P., Felix, J. F., Medina-Gomez, C., Rivadeneira, F., Wang, C., Ahluwalia, T. S., Vrijheid, M., Guxens, M., Sunyer, J., Tachmazidou, I., Walter, K., Iotchkova, V., Jackson, A., Cleal, L., Huffmann, J., Min, J. L. & Sass, L. & 7 others, Timmers, P. R. H. J., UK10K Consortium, Davey Smith, G., Cole, T. J., Timpson, N., Zeggini, E. & St Pourcain, B., 21 Jan 2019, In: Nature Communications. 10, 16 p., 357.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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29 Citations (Scopus)

280 Downloads (Pure)

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study

Johansson, M., Carreras-Torres, R., Scelo, G., Purdue, M. P., Mariosa, D., Muller, D. C., Timpson, N. J., Haycock, P. C., Brown, K. M., Wang, Z., Ye, Y., Hofmann, J. N., Foll, M., Gaborieau, V., Machiela, M. J., Colli, L. M., Li, P., Garnier, J.-G., Blanche, H. & Boland, A. & 93 others, Burdette, L., Prokhortchouk, E., Skryabin, K. G., Yeager, M., Radojevic-Skodric, S., Ognjanovic, S., Foretova, L., Holcatova, I., Janout, V., Mates, D., Mukeriya, A., Rascu, S., Zaridze, D., Bencko, V., Cybulski, C., Fabianova, E., Jinga, V., Lissowska, J., Lubinski, J., Navratilova, M., Rudnai, P., Benhamou, S., Cancel-Tassin, G., Cussenot, O., Weiderpass, E., Ljungberg, B., Tumkur Sitaram, R., Häggström, C., Bruinsma, F., Jordan, S. J., Severi, G., Winship, I., Hveem, K., Vatten, L. J., Fletcher, T., Larsson, S. C., Wolk, A., Banks, R. E., Selby, P. J., Easton, D. F., Andreotti, G., Beane Freeman, L. E., Koutros, S., Männistö, S., Weinstein, S., Clark, P. E., Edwards, T. L., Lipworth, L., Gapstur, S. M., Stevens, V. L., Carol, H., Freedman, M. L., Pomerantz, M. M., Cho, E., Wilson, K. M., Gaziano, J. M., Sesso, H. D., Freedman, N. D., Parker, A. S., Eckel-Passow, J. E., Huang, W.-Y., Kahnoski, R. J., Lane, B. R., Noyes, S. L., Petillo, D., Teh, B. T., Peters, U., White, E., Anderson, G. L., Johnson, L., Luo, J., Buring, J., Lee, I.-M., Chow, W.-H., Moore, L. E., Eisen, T., Henrion, M., Larkin, J., Barman, P., Leibovich, B. C., Choueiri, T. K., Lathrop, G. M., Deleuze, J.-F., Gunter, M., McKay, J. D., Wu, X., Houlston, R. S., Chanock, S. J., Relton, C., Richards, J. B., Martin, R. M., Davey Smith, G. & Brennan, P., Jan 2019, In: PLOS Medicine. 16, 1, p. e1002724 e1002724.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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73 Citations (Scopus)

325 Downloads (Pure)

Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis

Wade, K. H., Carslake, D., Tynelius, P., Davey Smith, G. & Martin, R. M., 9 Aug 2019, In: PLOS Medicine. 16, 8, 15 p., e1002868.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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15 Citations (Scopus)

219 Downloads (Pure)

2018

Assessing the causal association between 25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization

Dudding, T., Johansson, M., Thomas, S. J., Brennan, P., Martin, R. M. & Timpson, N. J., 1 Sept 2018, In: International Journal of Cancer. 143, 5, p. 1029-1036 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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25 Citations (Scopus)

369 Downloads (Pure)

Associations of body mass and fat indexes with cardiometabolic traits

Bell, J., Carslake, D., O'Keeffe, L., Frysz, M., Howe, L., Hamer, M., Wade, K., Timpson, N. & Davey Smith, G., 18 Dec 2018, In: Journal of the American College of Cardiology. 72, 24, p. 3142-3154 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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98 Citations (Scopus)

332 Downloads (Pure)

Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study

Bell, J., Hamer, M., Richmond, R., Timpson, N., Carslake, D. & Davey Smith, G., 11 Sept 2018, In: PLOS Medicine. 15, 9, 26 p., 1002649.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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39 Citations (Scopus)

348 Downloads (Pure)

Circulating selenium and prostate cancer risk: A mendelian randomization analysis

Yarmolinsky, J., Bonilla, C., Haycock, P., Langdon, R., Lotta, L. A., Langenberg, C., Relton, C., Lewis, S., Evans, D., Davey Smith, G. & Martin, R., Sept 2018, In: Journal of the National Cancer Institute. 110, 9, p. 1035-1038 4 p.

Research output: Contribution to journal › Article (Academic Journal)

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92 Citations (Scopus)

397 Downloads (Pure)

Consortium-based genome-wide meta-analysis for childhood dental caries traits

Haworth, S., Shungin, D., van der Tas, J. T., Vucic, S., Medina-Gomez, C., Yakimov, V., Feenstra, B., Shaffer, J. R., Lee, M. K., Standl, M., Thiering, E., Wang, C., Bønnelykke, K., Waage, J., Eyrich Jessen, L., Nørrisgaard, P. E., Joro, R., Seppälä, I., Raitakari, O. & Dudding, T. & 23 others, Grgic, O., Ongkosuwito, E., Vierola, A., Eloranta, A.-M., West, N. X., Thomas, S. J., McNeil, D. W., Levy, S. M., Slayton, R., Nohr, E. A., Lehtimäki, T., Lakka, T., Bisgaard, H., Pennell, C., Kühnisch, J., Marazita, M. L., Melbye, M., Geller, F., Rivadeneira, F., Wolvius, E. B., Franks, P. W., Johansson, I. & Timpson, N. J., 20 Jun 2018, (E-pub ahead of print) In: Human Molecular Genetics. 15 p., ddy237.

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36 Citations (Scopus)

1494 Downloads (Pure)

Epigenetic gestational age acceleration: A prospective cohort study investigating associations with familial, sociodemographic and birth characteristics

Khouja, J. N., Simpkin, A. J., O'Keeffe, L. M., Wade, K. H., Houtepen, L. C., Relton, C. L., Suderman, M. & Howe, L. D., 27 Jun 2018, In: Clinical Epigenetics. 10, 2 p., 86.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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49 Citations (Scopus)

319 Downloads (Pure)

Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study

Wootton, R., Lawn, R., Millard, L., Davies, N., Taylor, A., Munafo, M., Timpson, N., Davis, O. S. P., Davey Smith, G. & Haworth, C., 25 Sept 2018, In: BMJ. 362, 11 p., k3788.

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125 Citations (Scopus)

453 Downloads (Pure)

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K. H., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O'Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C. N. A., Pearson, E. R., Scott, R. A. & Van Heel, D. A. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In: Nature Communications. 9, 1, 11 p., 711.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

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52 Citations (Scopus)

349 Downloads (Pure)

Genetic architecture: The shape of the genetic contribution to human traits and disease

Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J. & Richards, J. B., 1 Feb 2018, In: Nature Reviews Genetics. 19, 2, p. 110-124 15 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

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298 Citations (Scopus)

1712 Downloads (Pure)

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study

Bell, J., Carslake, D., Wade, K., Richmond, R., Langdon, R., Vincent, E., Holmes, M., Timpson, N. & Davey Smith, G., 28 Aug 2018, In: PLOS Medicine. 15, 8, 25 p., e1002641.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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92 Citations (Scopus)

379 Downloads (Pure)

Reassessing the association between circulating Vitamin D and IGFBP-3: observational and Mendelian randomization estimates from independent sources

Tan, V., Biernacka, K., Dudding, T., Bonilla, C., Gilbert, B., Kaplan, R. C., Qi, Q., Teumer, A., Martin, R., Perks, C., the PRACTICAL Consortium, Timpson, N. & Holly, J. M. P., 2 Aug 2018, (E-pub ahead of print) In: Cancer Epidemiology, Biomarkers and Prevention. 30 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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8 Citations (Scopus)

214 Downloads (Pure)

Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis

O'Keeffe, L., Taylor, G., Huxley, R., Mitchell, P., Woodward, M. & Peters, S. A., 3 Oct 2018, In: BMJ Open. 8, 12 p., e021611.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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252 Citations (Scopus)

383 Downloads (Pure)

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

Richardson, T. G., Haycock, P. C., Zheng, J., Timpson, N. J., Gaunt, T. R., Smith, G. D., Relton, C. L. & Hemani, G., Sept 2018, In: Human Molecular Genetics. 27, 18, p. 3293-3304 12 p.

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42 Citations (Scopus)

322 Downloads (Pure)

The ethics conundrum in Recall by Genotype (RbG) research: perspectives from birth cohort participants

Minion, J. T., Butcher, F., Timpson, N. & Murtagh, M. J., 16 Aug 2018, In: PLOS ONE. 13, 8, 14 p., e0202502.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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11 Citations (Scopus)

314 Downloads (Pure)

Tooth loss is a complex measure of oral disease: determinants and methodological considerations

Haworth, S., Shungin, D., Kwak, S.-Y., Kim, H.-Y., West, N., Thomas, S., Franks, P. W., Timpson, N., Shin, M.-J. & Johansson, I., 29 Jun 2018, (E-pub ahead of print) In: Community Dentistry and Oral Epidemiology. 8 p.

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81 Citations (Scopus)

264 Downloads (Pure)

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications

Erzurumluoglu, A. M., Baird, D., Richardson, T. G., Timpson, N. J. & Rodriguez, S., Jan 2018, In: Genes. 9, 1, 11 p., 45.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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9 Citations (Scopus)

501 Downloads (Pure)

2017

AHRR (cg05575921) hypomethylation marks smoking behavior, morbidity and mortality

Bojesen, S. E., Timpson, N., Relton, C., Davey Smith, G. & Nordestgaard, B. G., 16 Jun 2017, In: Thorax. 72, 7, p. 646-653 8 p.

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139 Citations (Scopus)

320 Downloads (Pure)

A Pathway-centric Approach to Rare Variant Association Analysis

Richardson, T., Timpson, N., Campbell, C. & Gaunt, T., Jan 2017, In: European Journal of Human Genetics. 25, 1, p. 123-129 7 p.

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13 Citations (Scopus)

358 Downloads (Pure)

Association between Polygenic Risk Scores for Attention-Deficit Hyperactivity Disorder and Educational and Cognitive Outcomes in the General Population

Stergiakouli, E., Martin, J., Hamshere, M., Heron, J. E., St Pourcain, B., Timpson, N., Thapar, A. & Davey Smith, G., Apr 2017, In: International Journal of Epidemiology. 46, 2, p. 421–428 8 p.

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48 Citations (Scopus)

604 Downloads (Pure)

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study

Haycock, P. C., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., Willeit, P., Aviv, A., Gaunt, T. R., Hemani, G., Mangino, M., Ellis, H. P., Kurian, K. M., Pooley, K. A., Eeles, R. A., Lee, J. E. & Fang, S. & 31 others, Chen, W. V., Law, M. H., Bowdler, L. M., Iles, M. M., Yang, Q., Worrall, B. B., Markus, H. S., Hung, R. J., Amos, C. I., Spurdle, A. B., Thompson, D. J., O'Mara, T. A., Wolpin, B., Amundadottir, L., Stolzenberg-Solomon, R., Trichopoulou, A., Onland-Moret, N. C., Lund, E., Duell, E. J., Canzian, F., Severi, G., Overvad, K., Gunter, M. J., Tumino, R., Brennan, P., Paternoster, L., Soranzo, N., Relton, C. L., Martin, R. M., Davey Smith, G. & Telomeres Mendelian Randomization Collaboration, May 2017, In: JAMA Oncology. 3, 5, p. 636-651 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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442 Citations (Scopus)

411 Downloads (Pure)

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J. & Snieder, H. & 31 others, Kato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Tobin, M. D., Wain, L. V. & International Consortium of Blood Pressure (ICBP) 1000G Analyses, Mar 2017, In: Nature Genetics. 49, 3, p. 403-415 13 p.

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450 Citations (Scopus)

301 Downloads (Pure)

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Day, F. R., et al. & Perry, J. R. B., Jun 2017, In: Nature Genetics. 49, 6, p. 834-841 11 p.

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468 Citations (Scopus)

600 Downloads (Pure)

Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization

Gage, S. H., Jones, H. J., Taylor, A. E., Burgess, S., Zammit, S. & Munafò, M. R., 19 Jan 2017, In: Scientific Reports. 7, 8 p., 40653.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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46 Citations (Scopus)

367 Downloads (Pure)

Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis

Taylor, A., Martin, R., Geybels, M., Stanford, J. L., Shui, I., Eeles, R., Easton, D., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Wiklund, F., Grönberg, H., Haiman, C. A., Schleutker, J., Nordestgaard, B. G., Travis, R. C., Neal, D. E. & Pashayan, N. & 16 others, Tee Khaw, K., Blot, W. J., Thibodeau, S., Maier, C., Kibel, A. S., Cybulski, C., Cannon-Albright, L., Brenner, H., Park, J., Kaneva, R., Batra, J., Teixeira, M. R., Pandha, H., The PRACTICAL, C., Donovan, J. & Munafo, M., 15 Jan 2017, In: International Journal of Cancer. 140, 2, p. 322-328 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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19 Citations (Scopus)

1028 Downloads (Pure)

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

Manousaki, D., Dudding, T., Haworth, S., Hsu, Y.-H., Liu, C.-T., Medina-Gómez, C., Voortman, T., van der Velde, N., Melhus, H., Robinson-Cohen, C., Cousminer, D. L., Nethander, M., Vandenput, L., Noordam, R., Forgetta, V., Greenwood, C. M. T., Biggs, M. L., Psaty, B. M., Rotter, J. I. & Zemel, B. S. & 33 others, Mitchell, J. A., Taylor, B., Lorentzon, M., Karlsson, M., Jaddoe, V. V. W., Tiemeier, H., Campos-Obando, N., Franco, O. H., Utterlinden, A. G., Broer, L., van Schoor, N. M., Ham, A. C., Ikram, M. A., Karasik, D., de Mutsert, R., Rosendaal, F. R., den Heijer, M., Wang, T. J., Lind, L., Orwoll, E. S., Mook-Kanamori, D. O., Michaëlsson, K., Kestenbaum, B., Ohlsson, C., Mellström, D., de Groot, L. C. P. G. M., Grant, S. F. A., Kiel, D. P., Zillikens, M. C., Rivadeneira, F., Sawcer, S., Timpson, N. J. & Richards, J. B., 3 Aug 2017, In: American Journal of Human Genetics. 101, 2, p. 227-238 12 p.

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110 Citations (Scopus)

353 Downloads (Pure)

Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study

Taylor, P. N., Sayers, A., Okosieme, O., Das, G., Draman, M. S., Tabasum, A., Abusahmin, H., Rahman, M., Stevenson, K., Groom, A., Northstone, K., Woltersdorf, W. W., Taylor, A., Ring, S., Lazarus, J. H., Gregory, J. W., Rees, A., Timpson, N. & Dayan, C. M., 1 Jul 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2508–2515 8 p.

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40 Citations (Scopus)

366 Downloads (Pure)

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk

Richardson, T., Zheng, J., Davey Smith, G., Timpson, N., Gaunt, T., Relton, C. & Hemani, G., 5 Oct 2017, In: American Journal of Human Genetics. 101, 4, p. 590-602 13 p., 2443.

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55 Citations (Scopus)

328 Downloads (Pure)

Rare and low-frequency coding variants alter human adult height

Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T. & Karaderi, T. & 31 others, Locke, A. E., Masca, N. G. D., Ng, M. C. Y., Mudgal, P., Rivas, M. A., Vedantam, S., Mahajan, A., Guo, X., Abecasis, G., Aben, K. K., Adair, L. S., Alam, D. S., Albrecht, E., Allin, K. H., Allison, M., Amouyel, P., Appel, E. V., Arveiler, D., Chambers, J. C., Drenos, F., Mitchell, P., Palmer, C. N. A., Scott, R. A., Smith, J. A., Tansey, K. E., Walker, M., Warren, H. R., Wilson, J. G., Woods, M. O., Zhou, W. & EPIC InterAct Consortium, 9 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

482 Citations (Scopus)

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

Kreiner-Moller, E., Waage, J., Standl, M., Brix, S., Pers, T. H., Alves, A. C., Warrington, N. M., Tiesler, C. M. T., Fuertes, E., Franke, L., Hirschhorn, J. N., James, A., Simpson, A., Tung, J. Y., Koppelman, G. H., Postma, D. S., Pennell, C. E., Jarvelin, M.-R., Custovic, A. & Timpson, N. & 6 others, Ferreira, M. A., Strachan, D. P., Henderson, J., Hinds, D. A., Bisgaard, H. & Bønnelykke, K., 8 Feb 2017, (E-pub ahead of print) In: Journal of Allergy and Clinical Immunology. 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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62 Citations (Scopus)

642 Downloads (Pure)

Smoking and caffeine consumption: a genetic analysis of their association

Treur, J. L., Taylor, A. E., Ware, J. J., Nivard, M., Neale, M., McMahon, G., Hottenga, J. J., Baselmans, B. M. L., Boomsma, D. I., Munafo, M. R. & Vink, J., Jul 2017, In: Addiction Biology. 22, 4, p. 1090-1102 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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28 Citations (Scopus)

379 Downloads (Pure)

Ten years on: is dental general anaesthesia in childhood a risk factor for caries and anxiety?

Haworth, S., Dudding, T., Waylen, A., Thomas, S. & Timpson, N., Feb 2017, In: British Dental Journal. 222, 4, p. 299-304 6 p.

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36 Citations (Scopus)

475 Downloads (Pure)

The Association of Cigarette Smoking with Depression and Anxiety: A Systematic Review

Fluharty, M. E., Taylor, A. E., Grabski, M. & Munafò, M. R., 1 Jan 2017, In: Nicotine and Tobacco Research. 19, 1, p. 3-13 11 p.

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986 Citations (Scopus)

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Using genetic variation to explore the causal effect of maternal pregnancy adiposity on future offspring adiposity: a Mendelian randomization study

Richmond, R., Timpson, N., Felix, J. F., Palmer, T. M., Gaillard, R., McMahon, G., Davey Smith, G., Jaddoe, V. W. V. & Lawlor, D., 24 Jan 2017, In: PLOS Medicine. 14, 1, 17 p., e1002221.

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69 Citations (Scopus)

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Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

Tachmazidou, I., Süveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., McCarthy, S., Crawford, A. A., Bombieri, C., Cocca, M., Farmaki, A.-E., Gaunt, T. R., Jousilahti, P., Kooijman, M. N., Lehne, B. & Malerba, G. & 84 others, Männistö, S., Matchan, A., Medina-Gomez, C., Metrustry, S. J., Nag, A., Ntalla, I., Paternoster, L., Rayner, N. W., Sala, C., Scott, W. R., Shihab, H. A., Southam, L., St Pourcain, B., Traglia, M., Trajanoska, K., Zaza, G., Zhang, W., Artigas, M. S., Bansal, N., Benn, M., Chen, Z., Danecek, P., Lin, W.-Y., Locke, A., Luan, J., Manning, A. K., Mulas, A., Sidore, C., Tybjaerg-Hansen, A., Varbo, A., Zoledziewska, M., Finan, C., Hatzikotoulas, K., Hendricks, A. E., Kemp, J. P., Moayyeri, A., Panoutsopoulou, K., Szpak, M., Wilson, S. G., Boehnke, M., Cucca, F., Di Angelantonio, E., Langenberg, C., Lindgren, C., McCarthy, M. I., Morris, A. P., Nordestgaard, B. G., Scott, R. A., Tobin, M. D., Wareham, N. J., Burton, P., Chambers, J. C., Smith, G. D., Dedoussis, G., Felix, J. F., Franco, O. H., Gambaro, G., Gasparini, P., Hammond, C. J., Hofman, A., Jaddoe, V. W. V., Kleber, M., Kooner, J. S., Perola, M., Relton, C., Ring, S. M., Rivadeneira, F., Salomaa, V., Spector, T. D., Stegle, O., Toniolo, D., Uitterlinden, A. G., Barroso, I., Greenwood, C. M. T., Perry, J. R. B., Walker, B. R., Butterworth, A. S., Xue, Y., Durbin, R., Small, K. S., Soranzo, N., Timpson, N. J., Zeggini, E. & Bansal, N., 1 Jun 2017, In: American Journal of Human Genetics. 100, 6, p. 865-884 20 p.

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2016

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Paediatric Cohorts

Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Groen-Blokhuis, M. M., St. Pourcain, B., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., Vilor-Tejedor, N., Bacelis, J., Ebejer, J. L., Zhao, H., Davies, G. E., Ehli, E. A., Evans, D. M., Fedko, I. O., Guxens, M. & Hottenga, J.-J. & 31 others, Hudziak, J. J., Jugessur, A., Kemp, J. P., Krapohl, E., Martin, N. G., Murcia, M., Myhre, R., Ormel, J., Ring, S. M., Standl, M., Stergiakouli, E., Stoltenberg, C., Thiering, E., Timpson, N. J., Trzaskowski, M., van der Most, P. J., Wang, C., Nyholt, D. R., Medland, S. E., Neale, B., Jacobsson, B., Sunyer, J., Hartman, C. A., Whitehouse, A. J. O., Pennell, C. E., Heinrich, J., Plomin, R., Smith, G. D., Tiemeier, H., Posthuma, D. & Boomsma, D. I., Oct 2016, In: Journal of the American Academy of Child and Adolescent Psychiatry. 55, 10, p. 896-905.e6 16 p.

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A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways

Bustamante, M., Standl, M., Bassat, Q., Vilor-Tejedor, N., Medina-Gomez, C., Bonilla, C., Ahluwalia, T. S., Bacelis, J., Bradfield, J. P., Tiesler, C. M. T., Rivadeneira, F., Ring, S., Vissing, N. H., Fink, N. R., Jugessur, A., Mentch, F. D., Ballester, F., Kriebel, J., Kiefte-de Jong, J. C. & Wolsk, H. M. & 19 others, Llop, S., Thiering, E., Beth, S. A., Timpson, N. J., Andersen, J., Schulz, H., Jaddoe, V. W. V., Evans, D. M., Waage, J., Hakonarson, H., Grant, S. F. A., Jacobsson, B., Bønnelykke, K., Bisgaard, H., Smith, G. D., Moll, H. A., Heinrich, J., Estivill, X. & Sunyer, J., 15 Sept 2016, In: Human Molecular Genetics. 25, 18, p. 4127-4142 16 p.

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39 Citations (Scopus)

A protein domain and family based approach to rare variant association analysis

Richardson, T., Shihab, H., Rivas, M. A., McCarthy, M. I., Campbell, C., Timpson, N. & Gaunt, T., 29 Apr 2016, In: PLOS ONE. 11, 4, 12 p., e0153803.

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5 Citations (Scopus)

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A reference panel of 64,976 haplotypes for genotype imputation

McCarthy, S., Das, S., Kretzschmar, W., Delaneau, O., Wood, A. R., Teumer, A., Kang, H. M., Fuchsberger, C., Danecek, P., Sharp, K., Luo, Y., Sidore, C., Kwong, A., Timpson, N., Koskinen, S., Vrieze, S., Scott, L. J., Zhang, H., Mahajan, A. & Veldink, J. & 31 others, Peters, U., Pato, C., van Duijn, C. M., Gillies, C. E., Gandin, I., Mezzavilla, M., Gilly, A., Cocca, M., Traglia, M., Angius, A., Barrett, J. C., Boomsma, D., Branham, K., Breen, G., Brummett, C. M., Busonero, F., Campbell, H., Chan, A., Chen, S., Chew, E., Collins, F. S., Corbin, L. J., Smith, G. D., Dedoussis, G., Dorr, M., Farmaki, A.-E., Ferrucci, L., Forer, L., Min, J. L., Soranzo, N. & Haplotype Reference Consortium, Oct 2016, In: Nature Genetics. 48, 10, p. 1279-1283 5 p.

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Associations between smoking and caffeine consumption in two European cohorts

Treur, J. L., Taylor, A. E., Ware, J. J., McMahon, G., Hottenga, J.-J., Baselmans, B. M. L., Willemsen, G., Boomsma, D. I., Munafò, M. R. & Vink, J. M., 9 May 2016, In: Addiction. 111, 6, p. 1059-1068 10 p.

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80 Citations (Scopus)

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Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

Haycock, P. C., Burgess, S., Wade, K. H., Bowden, J., Relton, C. L. & Davey Smith, G., 1 Apr 2016, In: American Journal of Clinical Nutrition. 103, 4, p. 965-978 14 p.

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505 Citations (Scopus)

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BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization

Corbin, L. J., Richmond, R., Wade, K. H., Burgess, S., Bowden, J., Davey Smith, G. & Timpson, N., Oct 2016, In: Diabetes. 65, 10, p. 3002-3007 7 p.

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140 Citations (Scopus)

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Body mass index: Has epidemiology started to break down causal contributions to health and disease?

Corbin, L. J. & Timpson, N. J., Aug 2016, In: Obesity. 24, 8, p. 1630-1638 9 p.

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19 Citations (Scopus)

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