Multi-scale enzyme modelling for SynBio: optimizing biocatalysts for selective synthesis of bioactive compounds

Status	Finished
Effective start/end date	1/12/15 → 31/05/21
Links	http://gtr.rcuk.ac.uk/projects?ref=BB/M026280/1

Access Project

Antibiotic Origami: Selective Formation of Spirotetronates in Abyssomicin Biosynthesis
Mbatha, S. Z., Back, C., Devine, A. J., Mulliner, H. M., Johns, S. T., Lewin, H., Cheung, K. A., Zorn, K., Stach, J. E. M., Hayes, M. A., Van der Kamp, M. W., Race, P. R. & Willis, C. L., 12 Aug 2024, (E-pub ahead of print) In: Chemical Science. 15, 34, p. 14009-14015 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
Delineation of the Complete Reaction Cycle of a Natural Diels-Alderase
Maschio, L., Back, C., Al Nawah, J., Bowen, J. I., Johns, S. T., Mbatha, S. Z., Han, L.-C., Lees, N. R., Zorn, K., Stach, J. E. M., Hayes, M., Van der Kamp, M. W., Pudney, C. R., Burston, S. G., Willis, C. L. & Race, P. R., 24 Jun 2024, (E-pub ahead of print) In: Chemical Science. 15, 29, p. 11572-11583 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
1 Citation (Scopus)
Simulation-Guided Engineering Enables a Functional Switch in Selinadiene Synthase toward Hydroxylation
Srivastava, P., Johns, S. T., Voice, A., Morley, K., Escorcia Cabrera, A. M., Miller , D. J., Allemann, R. K. & Van der Kamp, M. W., 19 Jul 2024, In: ACS Catalysis. 14, 14, p. 11034-11043 10 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
2 Citations (Scopus)