Multi-scale enzyme modelling for SynBio: optimizing biocatalysts for selective synthesis of bioactive compounds

Van der Kamp, Marc W (Principal Investigator)

School of Biochemistry

Status	Finished
Effective start/end date	1/12/15 → 31/05/21
Links	http://gtr.rcuk.ac.uk/projects?ref=BB/M026280/1

Research Groups and Themes

BcompB
BCS and TECS CDTs
Bristol BioDesign Institute
BrisSynBio
Organic & Biological
Physical & Theoretical

Access Project

Project entry on Gateway to Research

16 Article (Academic Journal)
1 Letter (Academic Journal)

Antibiotic Origami: Selective Formation of Spirotetronates in Abyssomicin Biosynthesis
Mbatha, S. Z., Back, C., Devine, A. J., Mulliner, H. M., Johns, S. T., Lewin, H., Cheung, K. A., Zorn, K., Stach, J. E. M., Hayes, M. A., Van der Kamp, M. W., Race, P. R. & Willis, C. L., 14 Sept 2024, In: Chemical Science. 15, 34, p. 14009-14015 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
2 Citations (Scopus)
Delineation of the Complete Reaction Cycle of a Natural Diels-Alderase
Maschio, L., Back, C., Al Nawah, J., Bowen, J. I., Johns, S. T., Mbatha, S. Z., Han, L.-C., Lees, N. R., Zorn, K., Stach, J. E. M., Hayes, M., Van der Kamp, M. W., Pudney, C. R., Burston, S. G., Willis, C. L. & Race, P. R., 24 Jun 2024, (E-pub ahead of print) In: Chemical Science. 15, 29, p. 11572-11583 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
4 Citations (Scopus)
Simulation-Guided Engineering Enables a Functional Switch in Selinadiene Synthase toward Hydroxylation
Srivastava, P., Johns, S. T., Voice, A., Morley, K., Escorcia Cabrera, A. M., Miller , D. J., Allemann, R. K. & Van der Kamp, M. W., 19 Jul 2024, In: ACS Catalysis. 14, 14, p. 11034-11043 10 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
11 Citations (Scopus)