New pathogenic mechanisms in the long QT syndrome: KCNE1 modulation of hERG.

Hancox, Jules C (Principal Investigator)

School of Physiology, Pharmacology & Neuroscience

Status	Finished
Effective start/end date	29/03/15 → 28/09/17

4 Article (Academic Journal)
1 Letter (Academic Journal)

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide
Dawidowski, M., Król, M., Szulczyk, B., Chodkowski, A., Podsadni, P., Konopelski, P., Ufnal, M., Szuberski, P., Wróbel, M. Z., Zhang, Y., El Harchi, A., Hancox, J. C., Jarkovska, D., Mistrova, E., Sviglerova, J., Štengl, M., Popowicz, G. M. & Turło, J., 1 May 2020, In: Bioorganic chemistry. 98, 14 p., 103717.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
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1 Citation (Scopus)

67 Downloads (Pure)
Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker
Helliwell, M. V., Zhang, Y., El Harchi, A., Du, C., Hancox, J. C. & Dempsey, C. E., 4 May 2018, In: Journal of Biological Chemistry. 293, 18, p. 7040-7057 38 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access
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34 Citations (Scopus)

281 Downloads (Pure)
The basis for low-affinity hERG potassium channel block by sotalol
Zhang, Y., Dempsey, C. & Hancox, J., 27 Sept 2017, In: Journal of Pharmacology and Pharmacotherapeutics. 8, 3, p. 130-131 2 p.
Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access
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6 Citations (Scopus)

110 Downloads (Pure)