Proteomic identification of serum biomarkers for dengue disease severity.

Dengue is the most important arthropod-borne viral disease of humans and endemic in the Philippines, where it is a leading cause of morbidity. Dengue has a wide spectrum of clinical presentations, but there is no diagnostic test to determine whether a patient will progress to the potentially fatal dengue haemorrhagic fever, leading to unnecessary hospitalisation of patients with milder disease. The project aims to analyse serum samples from Filipino patients with varying grades of dengue, using high-throughput proteomics, to identify potential biomarkers to predict disease severity. The project will build on an existing collaboration between UK and Filipino partners.

Dengue is the most important arthropod-borne viral disease of humans and endemic in the Philippines, where it is a leading cause of morbidity. Dengue has a wide spectrum of clinical presentations, but there is no diagnostic test to determine whether a patient will progress to the potentially fatal dengue haemorrhagic fever, leading to unnecessary hospitalisation of patients with milder disease. The project aims to analyse serum samples from Filipino patients with varying grades of dengue, using high-throughput proteomics, to identify potential biomarkers to predict disease severity. The project will build on an existing collaboration between UK and Filipino partners.

In progress