Remote Evaluation of Sleep To enhance understanding of Early Dementia

The RESTED Study has four major aims. Firstly to improve the characterisation of sleep disturbance and biological rhythms in cognitive impairment / dementia, secondly to understand more about the variability of cognitive performance in relation to sleep, thirdly to enhance remote delivery of sleep research and finally to understand more about the role of dopamine in sleep and memory.

The study is an observational cohort design recruiting into four separate groups; participants with early Alzheimer’s Dementia (AD) or Mild Cognitive Impairment (MCI) secondary to AD, participants with Lewy Body Dementia / Dementia with Lewy Bodies Mild Cognitive Impairment / Parkinson’s Disease Mild Cognitive Impairment, Healthy Older Adults and participants with Dopa Responsive Dystonia.

The first three groups will wear a wrist actigraph monitoring sleep over an 8 week period. For one of these eight weeks they will also wear a headband which monitors EEG signals and complete cognitive tests. These devices will be worn entirely at home. During the week of wearing the headband, participants in these first three groups will also be asked to collect a saliva sample from home. This is in order to quantify levels of melatonin and cortisol, hormones related to circadian rhythm.