Research output per year
Research output per year
- 21 results
Search results
-
2018
Therapeutic approaches to CFTR dysfunction: from discovery to drug development
Li, H., Pesce, E., Sheppard, D. N., Singh, A. K. & Pedemonte, N., 1 Mar 2018, In: Journal of Cystic Fibrosis. 17, 2, p. S14-S21 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile37 Citations (Scopus)407 Downloads (Pure) -
2017
Bypassing CFTR dysfunction in cystic fibrosis with alternative pathways for anion transport
Li, H., Salomon, J. J., Sheppard, D. N., Mall, M. A. & Galietta, L. J., 2017, In: Current Opinion in Pharmacology. 34, p. 91-97 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile61 Citations (Scopus)641 Downloads (Pure) -
2016
Efficient, non‐toxic anion transport by synthetic carriers in cells and epithelia
Li, H., Valkenier, H., Judd, L. W., Brotherhood, P. R., Hussain, S., Cooper, J. A., Jurček, O., Sparkes, H. A., Sheppard, D. N. & Davis, A. P., Jan 2016, In: Nature Chemistry. 8, 1, p. 24-32 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile137 Citations (Scopus)533 Downloads (Pure) -
Nonprotonophoric electrogenic Cl− transport mediated by valinomycin-like carriers
Wu, X., Judd, L., Howe, E. N. W., Withecombe, A. M., Soto-Cerrato, V., Li, H., Busschaert, N., Valkenier-Van Dijk, H., Pérez-Tomás, R., Sheppard, D., Jiang, Y.-B., Davis, A. & Gale, P. A., 7 Jul 2016, In: Chem. 1, 1, p. 127-146 20 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile129 Citations (Scopus)409 Downloads (Pure) -
Targeted anion transporter delivery by coiled-coil driven membrane fusion
Mora, N. L., Bahreman, A., Valkenier, H., Li, H., Sharp, T. H., Sheppard, D. N., Davis, A. P. & Kros, A., 1 Mar 2016, In: Chemical Science. 7, 3, p. 1768-1772 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile44 Citations (Scopus)296 Downloads (Pure) -
Tilting and Tumbling in Transmembrane Anion Carriers: Activity Tuning through n-Alkyl Substitution
Edwards, S. J., Marques, I., Dias, C. M., Tromans, R. A., Lees, N. R., Félix, V., Valkenier, H. & Davis, A. P., 25 Jan 2016, In: Chemistry - A European Journal. 22, 6, p. 2004-2011 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile24 Citations (Scopus)375 Downloads (Pure) -
2015
Biotin[6]uril Esters: Chloride-selective transmembrane anion carriers employing C-H···anion interactions
Lisbjerg, M., Valkenier, H., Jessen, B. M., Al-Kerdi, H., Davis, A. P. & Pittelkow, M., 8 Apr 2015, In: Journal of the American Chemical Society. 137, 15, p. 4948-4951 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
120 Citations (Scopus) -
Exploiting species differences to understand the CFTR Cl- channel
Bose, S., Scott-Ward, T., Cai, Z. & Sheppard, D., 1 Oct 2015, In: Biochemical Society Transactions. 43, 5, p. 975-982 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile12 Citations (Scopus)459 Downloads (Pure) -
High-Affinity Anion Binding by Steroidal Squaramide Receptors
Edwards, S. J., Valkenier, H., Busschaert, N., Gale, P. A. & Davis, A. P., 7 Apr 2015, In: Angewandte Chemie - International Edition. 54, 15, p. 4592-4596 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
109 Citations (Scopus) -
Sterically geared tris-thioureas; transmembrane chloride transporters with unusual activity and accessibility
Valkenier, H., Dias, C. M., Porter Goff, K. L., Jurček, O., Puttreddy, R., Rissanen, K. & Davis, A. P., 30 Jul 2015, In: Chemical Communications. 51, 75, p. 14235-14238 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
31 Citations (Scopus) -
Visualization and quantification of transmembrane ion transport into giant unilamellar vesicles
Valkenier, H., López Mora, N., Kros, A. & Davis, A. P., 9 Feb 2015, In: Angewandte Chemie - International Edition. 54, 7, p. 2137-2141 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
37 Citations (Scopus) -
2014
A flexible solution to anion transport: Powerful anionophores based on a cyclohexane scaffold
Cooper, J. A., Street, S. T. G. & Davis, A. P., 26 May 2014, In: Angewandte Chemie - International Edition. 53, 22, p. 5609-5613 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
50 Citations (Scopus) -
CFTR potentiators partially restore channel function to A561E, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR
Wang, Y., Liu, J., Loizidou, A., Bugeja, L. A., Warner, R., Hawley, B. R., Cai, Z., Toye, A. M., Sheppard, D. N. & Li, H., 5 Jun 2014, In: British Journal of Pharmacology.Research output: Contribution to journal › Article (Academic Journal) › peer-review
23 Citations (Scopus) -
Lipophilic balance - a new design principle for transmembrane anion carriers
Valkenier, H., Haynes, C. J. E., Herniman, J., Gale, P. A. & Davis, A. P., Mar 2014, In: Chemical Science. 5, 3, p. 1128-1134 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
70 Citations (Scopus) -
Preorganized bis-thioureas as powerful anion carriers: Chloride transport by single molecules in large unilamellar vesicles
Valkenier, H., Judd, L. W., Li, H., Hussain, S., Sheppard, D. N. & Davis, A. P., 3 Sept 2014, In: Journal of the American Chemical Society. 136, 35, p. 12507-12512 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
85 Citations (Scopus) -
Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models
Wang, Y., Wrennall, J. A., Cai, Z., Li, H. & Sheppard, D. N., Jul 2014, In: International Journal of Biochemistry and Cell Biology. 52, p. 47-57 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
94 Citations (Scopus) -
2013
Making a Match for Valinomycin: Steroidal Scaffolds in the Design of Electroneutral, Electrogenic Anion Carriers
Valkenier, H. & Davis, A. P., 17 Dec 2013, In: Accounts of Chemical Research. 46, 12, p. 2898-2909 12 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
97 Citations (Scopus) -
2011
Diaxial diureido decalins as compact, efficient, and tunable anion transporters
Hussain, S., Brotherhood, P., Judd, L. & Davis, A., 2011, In: Journal of the American Chemical Society. 133, p. 1614 - 1617Research output: Contribution to journal › Article (Academic Journal) › peer-review
80 Citations (Scopus) -
Thiourea isosteres as anion receptors and transmembrane transporters
Wenzel, M., Light, M. E., Davis, A. P. & Gale, P. A., 2011, In: Chemical Communications. 47, 27, p. 7641-7643 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
43 Citations (Scopus) -
2010
From cholapod to cholaphane transmembrane anion carriers: accelerated transport through binding site enclosure
Judd, L. W. & Davis, A. P., 2010, In: Chemical Communications. 46, 13, p. 2227-2229 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
54 Citations (Scopus) -
Steroid-based anion receptors and transporters
Brotherhood, P. R. & Davis, A. P., 2010, In: Chemical Society Reviews. 39, 10, p. 3633-3647 15 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
165 Citations (Scopus)