Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach

Research output

Research output per year 2013 2014 2015 2016 2017 2018 2018

• 21 Article (Academic Journal)
• 1 Review article (Academic Journal)

Research output per year

Research output per year

Search results

• 2018

  Anion recognition by a bioactive diureidodecalin anionophore: solid-state, solution, and computational studies

  Jurček, O., Valkenier, H., Puttreddy, R., Novák, M., Sparkes, H. A., Marek, R., Rissanen, K. & Davis, A. P., 7 Jun 2018, In: Chemistry - A European Journal. 24, 32, p. 8178-8185 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Strength 100%
  • Development 100%
  • Solution and Solubility 100%
  • Binding Site 100%
  • Crystal Structure 100%
  8 Citations (Scopus)

  259 Downloads (Pure)

• Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes

  Dias, C. M., Li, H., Valkenier, H., Karagiannidis, L. E., Gale, P. A., Sheppard, D. N. & Davis, A. P., 21 Feb 2018, In: Organic and Biomolecular Chemistry. 16, 7, p. 1083-1087 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Urea 100%
  • Halide 50%
  • Yellow Fluorescent Protein 50%
  37 Citations (Scopus)

  280 Downloads (Pure)

• Anthracene Bisureas as Powerful and Accessible Anion Carriers

  Dias, C. M., Valkenier, H. & Davis, A. P., 20 Apr 2018, In: Chemistry - A European Journal. 24, 23, p. 6262-6268 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Anion 100%
  • Anthracene 50%
  • Transporters 33%
  • Application 16%
  • Potential 16%
  21 Citations (Scopus)

  226 Downloads (Pure)

• Therapeutic approaches to CFTR dysfunction: from discovery to drug development

  Li, H., Pesce, E., Sheppard, D. N., Singh, A. K. & Pedemonte, N., 1 Mar 2018, In: Journal of Cystic Fibrosis. 17, 2, p. S14-S21 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Cystic Fibrosis 62%
  • Regulator Protein 37%
  • Adenosine Triphosphate 12%
  • Drug Development 12%
  30 Citations (Scopus)

  347 Downloads (Pure)
• 2017

  A folding decalin tetra-urea for transmembrane anion transport

  Valkenier, H., Dias, C. M., Butts, C. P. & Davis, A. P., 17 Aug 2017, In: Tetrahedron. 73, 33, p. 4955-4962 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Anion 100%
  • Urea 50%
  • Decalin 50%
  • NMR Spectroscopy 16%
  • Hydrogen Bonding 16%
  11 Citations (Scopus)

  393 Downloads (Pure)

• Bypassing CFTR dysfunction in cystic fibrosis with alternative pathways for anion transport

  Li, H., Salomon, J. J., Sheppard, D. N., Mall, M. A. & Galietta, L. J., 2017, In: Current Opinion in Pharmacology. 34, p. 91-97 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Cystic Fibrosis 60%
  • Chloride Channel 60%
  • Lung Disease 20%
  • Solute Carrier Protein 20%
  51 Citations (Scopus)

  537 Downloads (Pure)

• Two Small Molecules Restore Stability to a Sub-population of the Cystic Fibrosis Transmembrane conductance Regulator with the Predominant Disease-causing Mutation

  Meng, X., Wang, Y., Wang, X., Wrennall, J., Rimington, T., Li, H., Cai, Z., Ford, R. C. & Sheppard, D., 3 Mar 2017, In: Journal of Biological Chemistry. 292, 9, p. 3706-3719 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Cystic Fibrosis 20%
  • Lumacaftor 20%
  • Chloride Channel 20%
  • Length 15%
  35 Citations (Scopus)

  373 Downloads (Pure)
• 2016

  Efficient, non‐toxic anion transport by synthetic carriers in cells and epithelia

  Li, H., Valkenier, H., Judd, L. W., Brotherhood, P. R., Hussain, S., Cooper, J. A., Jurček, O., Sparkes, H. A., Sheppard, D. N. & Davis, A. P., Jan 2016, In: Nature Chemistry. 8, 1, p. 24-32 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Anion Channel 100%
  • Biological Product 100%
  • Cystic Fibrosis 100%
  • Toxicity 50%
  • Biological Activity 50%
  115 Citations (Scopus)

  449 Downloads (Pure)

• Nonprotonophoric electrogenic Cl− transport mediated by valinomycin-like carriers

  Wu, X., Judd, L., Howe, E. N. W., Withecombe, A. M., Soto-Cerrato, V., Li, H., Busschaert, N., Valkenier-Van Dijk, H., Pérez-Tomás, R., Sheppard, D., Jiang, Y-B., Davis, A. & Gale, P. A., 7 Jul 2016, In: Chem. 1, 1, p. 127-146 20 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Anion 100%
  • Valinomycin 100%
  • Correlation 66%
  • Acidity 66%
  • Liposome 66%
  111 Citations (Scopus)

  350 Downloads (Pure)

• Targeted anion transporter delivery by coiled-coil driven membrane fusion

  Mora, N. L., Bahreman, A., Valkenier, H., Li, H., Sharp, T. H., Sheppard, D. N., Davis, A. P. & Kros, A., 1 Mar 2016, In: Chemical Science. 7, 3, p. 1768-1772 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cell Membrane 100%
  • Coiled Coil 100%
  • Target Cell 66%
  • Membrane Fusion 66%
  • Fluorescence Microscopy 66%
  37 Citations (Scopus)

  263 Downloads (Pure)

• Tilting and Tumbling in Transmembrane Anion Carriers: Activity Tuning through n-Alkyl Substitution

  Edwards, S. J., Marques, I., Dias, C. M., Tromans, R. A., Lees, N. R., Félix, V., Valkenier, H. & Davis, A. P., 25 Jan 2016, In: Chemistry - A European Journal. 22, 6, p. 2004-2011 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Chloride 100%
  • Alkyl Group 100%
  • Binding Site 33%
  • Carbon 33%
  • Cystic Fibrosis 33%
  21 Citations (Scopus)

  330 Downloads (Pure)
• 2015

  Biotin[6]uril Esters: Chloride-selective transmembrane anion carriers employing C-H···anion interactions

  Lisbjerg, M., Valkenier, H., Jessen, B. M., Al-Kerdi, H., Davis, A. P. & Pittelkow, M., 8 Apr 2015, In: Journal of the American Chemical Society. 137, 15, p. 4948-4951 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Anion 100%
  • Chloride 28%
  • Biotin 28%
  • Hydrophilicity 14%
  • Reaction Selectivity 14%
  107 Citations (Scopus)

• Exploiting species differences to understand the CFTR Cl^- channel

  Bose, S., Scott-Ward, T., Cai, Z. & Sheppard, D., 1 Oct 2015, In: Biochemical Society Transactions. 43, 5, p. 975-982 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Cystic Fibrosis 25%
  • ABC Transporter 25%
  • Species 12%
  • Protein 12%
  12 Citations (Scopus)

  397 Downloads (Pure)

• High-Affinity Anion Binding by Steroidal Squaramide Receptors

  Edwards, S. J., Valkenier, H., Busschaert, N., Gale, P. A. & Davis, A. P., 7 Apr 2015, In: Angewandte Chemie - International Edition. 54, 15, p. 4592-4596 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Anion 100%
  • Group 25%
  • Receptor 25%
  • Strength 8%
  • Tetraethylammonium 8%
  90 Citations (Scopus)

• Sterically geared tris-thioureas; transmembrane chloride transporters with unusual activity and accessibility

  Valkenier, H., Dias, C. M., Porter Goff, K. L., Jurček, O., Puttreddy, R., Rissanen, K. & Davis, A. P., 30 Jul 2015, In: Chemical Communications. 51, 75, p. 14235-14238 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Anion 100%
  • Tris 75%
  • Trometamol 75%
  • Chloride 25%
  • Thiourea 25%
  29 Citations (Scopus)

• Visualization and quantification of transmembrane ion transport into giant unilamellar vesicles

  Valkenier, H., López Mora, N., Kros, A. & Davis, A. P., 9 Feb 2015, In: Angewandte Chemie - International Edition. 54, 7, p. 2137-2141 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Microscopy 100%
  • Ion Transport 100%
  • Electric Potential 50%
  • Development 50%
  • Light 50%
  33 Citations (Scopus)
• 2014

  A flexible solution to anion transport: Powerful anionophores based on a cyclohexane scaffold

  Cooper, J. A., Street, S. T. G. & Davis, A. P., 26 May 2014, In: Angewandte Chemie - International Edition. 53, 22, p. 5609-5613 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cyclohexane 100%
  • Biological Activity 50%
  • Cystic Fibrosis 50%
  • Channelopathy 50%
  • Thiourea 50%
  48 Citations (Scopus)

• CFTR potentiators partially restore channel function to A561E, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR

  Wang, Y., Liu, J., Loizidou, A., Bugeja, L. A., Warner, R., Hawley, B. R., Cai, Z., Toye, A. M., Sheppard, D. N. & Li, H., 5 Jun 2014, In: British Journal of Pharmacology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Cystic Fibrosis 22%
  • Effusion 9%
  • Iodide 9%
  • Thermostability 9%
  19 Citations (Scopus)

• Lipophilic balance - a new design principle for transmembrane anion carriers

  Valkenier, H., Haynes, C. J. E., Herniman, J., Gale, P. A. & Davis, A. P., Mar 2014, In: Chemical Science. 5, 3, p. 1128-1134 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Phenylthiocarbamide 100%
  • Chloride 50%
  • Carbon 11 50%
  • Thiourea 50%
  • Lipophilicity 50%
  65 Citations (Scopus)

• Preorganized bis-thioureas as powerful anion carriers: Chloride transport by single molecules in large unilamellar vesicles

  Valkenier, H., Judd, L. W., Li, H., Hussain, S., Sheppard, D. N. & Davis, A. P., 3 Sep 2014, In: Journal of the American Chemical Society. 136, 35, p. 12507-12512 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Thiourea 100%
  • Urea 75%
  • Chloride 50%
  • Decalin 50%
  • Cystic Fibrosis 50%
  76 Citations (Scopus)

• Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models

  Wang, Y., Wrennall, J. A., Cai, Z., Li, H. & Sheppard, D. N., Jul 2014, In: International Journal of Biochemistry and Cell Biology. 52, p. 47-57 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Mutation 55%
  • Cystic Fibrosis 55%
  • Comprehension 22%
  • Animal Models 22%
  86 Citations (Scopus)
• 2013

  Making a Match for Valinomycin: Steroidal Scaffolds in the Design of Electroneutral, Electrogenic Anion Carriers

  Valkenier, H. & Davis, A. P., 17 Dec 2013, In: Accounts of Chemical Research. 46, 12, p. 2898-2909 12 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  • Molecule 100%
  • Valinomycin 100%
  • Steroid 75%
  • Steroids 75%
  • Membrane 50%
  83 Citations (Scopus)