γ-Lactones from δ-lactones: total synthesis of the biosynthetic derailment product mupirocin H

Robert W Scott, Carlo Mazzetti, Thomas J Simpson, Christine L Willis

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)

Abstract

Two different strategies for the synthesis of functionalised γ-lactones from δ-lactones are described and used in a convergent synthesis of (+)-mupirocin H. The total synthesis is versatile and may be readily adapted for the preparation of further truncated metabolites from Pseudomonas fluorescens.
Original languageEnglish
Pages (from-to)2639-41
Number of pages3
JournalChemical Communications
Volume48
Issue number20
DOIs
Publication statusPublished - 2012

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