γ-Lactones from δ-lactones: total synthesis of the biosynthetic derailment product mupirocin H

Robert W Scott; Carlo Mazzetti; Thomas J Simpson; Christine L Willis

doi:10.1039/c2cc17721h

γ-Lactones from δ-lactones: total synthesis of the biosynthetic derailment product mupirocin H

Robert W Scott
, Carlo Mazzetti
, Thomas J Simpson
, Christine L Willis

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

Abstract

Two different strategies for the synthesis of functionalised γ-lactones from δ-lactones are described and used in a convergent synthesis of (+)-mupirocin H. The total synthesis is versatile and may be readily adapted for the preparation of further truncated metabolites from Pseudomonas fluorescens.

Original language	English
Pages (from-to)	2639-41
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	20
DOIs	https://doi.org/10.1039/c2cc17721h
Publication status	Published - 2012

Research Groups and Themes

Organic & Biological

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CHEMICAL ANALYSIS OF THE MUPIROCIN GENE CLUSTER FROM PSEUDOMONAS FLUORESCENS
Simpson, T. J. (Principal Investigator)
1/10/04 → 1/01/08
Project: Research

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@article{8048d74a983e489091a9ea4010481b99,

title = "γ-Lactones from δ-lactones: total synthesis of the biosynthetic derailment product mupirocin H",

abstract = "Two different strategies for the synthesis of functionalised γ-lactones from δ-lactones are described and used in a convergent synthesis of (+)-mupirocin H. The total synthesis is versatile and may be readily adapted for the preparation of further truncated metabolites from Pseudomonas fluorescens.",

author = "Scott, \{Robert W\} and Carlo Mazzetti and Simpson, \{Thomas J\} and Willis, \{Christine L\}",

note = "This journal is {\textcopyright} The Royal Society of Chemistry 2012",

year = "2012",

doi = "10.1039/c2cc17721h",

language = "English",

volume = "48",

pages = "2639--41",

journal = "Chemical Communications",

issn = "1364-548X",

publisher = "Royal Society of Chemistry",

number = "20",

}

TY - JOUR

T1 - γ-Lactones from δ-lactones

T2 - total synthesis of the biosynthetic derailment product mupirocin H

AU - Scott, Robert W

AU - Mazzetti, Carlo

AU - Simpson, Thomas J

AU - Willis, Christine L

PY - 2012

Y1 - 2012

N2 - Two different strategies for the synthesis of functionalised γ-lactones from δ-lactones are described and used in a convergent synthesis of (+)-mupirocin H. The total synthesis is versatile and may be readily adapted for the preparation of further truncated metabolites from Pseudomonas fluorescens.

AB - Two different strategies for the synthesis of functionalised γ-lactones from δ-lactones are described and used in a convergent synthesis of (+)-mupirocin H. The total synthesis is versatile and may be readily adapted for the preparation of further truncated metabolites from Pseudomonas fluorescens.

U2 - 10.1039/c2cc17721h

DO - 10.1039/c2cc17721h

M3 - Article (Academic Journal)

C2 - 22294025

SN - 1364-548X

SN - 2050-5639

VL - 48

SP - 2639

EP - 2641

JO - Chemical Communications

JF - Chemical Communications

IS - 20

ER -

γ-Lactones from δ-lactones: total synthesis of the biosynthetic derailment product mupirocin H

Abstract

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CHEMICAL ANALYSIS OF THE MUPIROCIN GENE CLUSTER FROM PSEUDOMONAS FLUORESCENS

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