ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ

Yu B. Lishmanov; L. N. Maslov; A. V. Krylatov; Igor Khaliulin

doi:10.1007/s11055-016-0362-2

ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ

Translated title of the contribution: Mimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase

Yu B. Lishmanov^*, L. N. Maslov, A. V. Krylatov, Igor Khaliulin

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.

Translated title of the contribution	Mimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase
Original language	Russian
Pages (from-to)	25-32
Number of pages	8
Journal	Neuroscience and Behavioral Physiology
Volume	47
Issue number	1
Early online date	16 Nov 2016
DOIs	https://doi.org/10.1007/s11055-016-0362-2
Publication status	Published - 1 Jan 2017

Bibliographical note

N.b. accepted manuscript is written in the original Russian.

Keywords

cannabinoids
heart
ischemia
NO synthase
preconditioning
protein kinase C
reperfusion

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Lishmanov, Y. B., Maslov, L. N., Krylatov, A. V., & Khaliulin, I. (2017). ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ. Neuroscience and Behavioral Physiology, 47(1), 25-32. https://doi.org/10.1007/s11055-016-0362-2

Lishmanov, Yu B. ; Maslov, L. N. ; Krylatov, A. V. et al. / ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ : РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ. In: Neuroscience and Behavioral Physiology. 2017 ; Vol. 47, No. 1. pp. 25-32.

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title = "ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ",

abstract = "Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.",

keywords = "cannabinoids, heart, ischemia, NO synthase, preconditioning, protein kinase C, reperfusion",

author = "Lishmanov, {Yu B.} and Maslov, {L. N.} and Krylatov, {A. V.} and Igor Khaliulin",

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doi = "10.1007/s11055-016-0362-2",

language = "Russian",

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Lishmanov, YB, Maslov, LN, Krylatov, AV & Khaliulin, I 2017, 'ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ', Neuroscience and Behavioral Physiology, vol. 47, no. 1, pp. 25-32. https://doi.org/10.1007/s11055-016-0362-2

ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ. / Lishmanov, Yu B.; Maslov, L. N.; Krylatov, A. V. et al.
In: Neuroscience and Behavioral Physiology, Vol. 47, No. 1, 01.01.2017, p. 25-32.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

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T2 - РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ

AU - Lishmanov, Yu B.

AU - Maslov, L. N.

AU - Krylatov, A. V.

AU - Khaliulin, Igor

N1 - N.b. accepted manuscript is written in the original Russian.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.

AB - Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.

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KW - ischemia

KW - NO synthase

KW - preconditioning

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SN - 0097-0549

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Lishmanov YB, Maslov LN, Krylatov AV, Khaliulin I. ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ. Neuroscience and Behavioral Physiology. 2017 Jan 1;47(1):25-32. Epub 2016 Nov 16. doi: 10.1007/s11055-016-0362-2

ИМИТАЦИЯ ФЕНОМЕНА ИШЕМИЧЕСКОГО ПРЕКОНДИЦИОНИРОВАНИЯ ЧЕРЕЗ ВОЗДЕЙСТВИЕ НА КАННАБИНОИДНЫЕ РЕЦЕПТОРЫ: РОЛЬ ПРОТЕИНКИНАЗЫ С И NO-СИНТАЗЫ

Abstract

Bibliographical note

Keywords

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